Improving Adherence Among HIV+ Rwandan Youth: A TI-CBTe Indigenous Leader Model
提高艾滋病毒卢旺达青年的依从性:TI-CBTe 土著领袖模型
基本信息
- 批准号:8601541
- 负责人:
- 金额:$ 46.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:21 year old6 year oldAIDS/HIV problemAccountingAcquired Immunodeficiency SyndromeAddressAdherenceAdolescentAdolescent and Young AdultAdultAfrica South of the SaharaAgeAnti-Retroviral AgentsAttitudeCaregiversCaringClinicCognitive TherapyComorbidityComplexCountryDataDistressEconomicsEnsureEpidemicEvidence based interventionFaceFeeling hopelessForcible intercourseFutureGenderGender RoleGoalsHIVHealthHealth PrioritiesIndigenousInfectionInterventionLeftLifeLife ExpectancyLinkLogisticsMeasurementMediator of activation proteinMedical centerMedicineMental DepressionMental HealthModelingMorbidity - disease rateNoiseOutcomeParentsParticipantPatient Self-ReportPerinatalPharmaceutical PreparationsPopulationPrevalenceProductivityProviderPsychologistPsychosocial Assessment and CareQuality of lifeRandomizedReportingResearchResearch InfrastructureResourcesRwandaServicesSex BehaviorSiteSurvivorsTarget PopulationsTechniquesTestingTimeTrainingTraumaTreatment outcomeViolenceViralViral Load resultVirusWomanYouthantiretroviral therapyarmbasecomparative efficacyexperiencefollow-upglobal healthimprovedinnovationmedication compliancemeetingsmortalitymultidisciplinaryoutreachpillprogramspublic health relevanceresistant strainrole modelsexual violencetransmission processtreatment as usualtreatment strategy
项目摘要
DESCRIPTION (provided by applicant): Like most of sub-Saharan Africa, Rwandan youth are the epicenter of the AIDS epidemic, accounting for 40% of new infections. Antiretroviral (ART) adherence is a global health priority, but Rwandan youth are more than twice as likely to be on second line therapy as adults, and with a median population age of 18.7 years old, adherence is essential for Rwanda's future. Resources to provide youth-centered medical and psychosocial care are limited in Rwanda, and young people with HIV face many obstacles to adherence, namely the long-term consequences of genocide, depression, and gender-based violence, as well as logistical issues, negative attitudes, and insufficient parent/caregiver support. Preliminary data underscore the utility of culturally-adapted, trauma-informed cognitive behavioral therapy (TI-CBT) in reducing depression and traumatic distress among youth and adults in Rwanda. This project proposes a 2-arm RCT to test and compare the efficacy of adherence-enhanced TI-CBT (i.e., TI-CBTe) to usual care in increasing ART adherence among 350 Rwandan 14 - 21 year olds from the two clinics caring for the largest number of youth with HIV in Rwanda. Based on the Indigenous Leader Outreach Model, we will train 20 HIV+ indigenous youth leaders who are > 95% ART adherent (IYL) and supervising psychologists to deliver the intervention. Youth, caregivers, and IYL will complete baseline, 6-, and 12-month follow-up assessments to assess effects on adherence and important mediators (trauma, depression, gender-based violence). We will use an intent-to-treat analysis and a combination of regression techniques and other inferential statistical tests for contrasting means and proportions. We will analyze treatment outcomes using logistic and linear multiple regression models examining effects at 6- and 12- months separately, as well as a combined model with random effects for repeated measurements across time. This proposal answers a compelling need for innovative programs to increase ART adherence among HIV+ youth. If effective, the study will build Rwanda's capacity to provide much needed services; and, involvement by the Rwanda Biomedical Center will ensure wide dissemination.
描述(申请人提供):像大多数撒哈拉以南非洲国家一样,卢旺达青年是艾滋病流行的中心,占新感染病例的40%。坚持抗逆转录病毒疗法(ART)是全球卫生优先事项,但卢旺达青年接受二线治疗的可能性是成年人的两倍多,由于人口年龄中值为18.7岁,坚持抗逆转录病毒治疗对卢旺达的未来至关重要。在卢旺达,提供以青年为中心的医疗和心理社会护理的资源有限,艾滋病毒携带者在坚持治疗方面面临许多障碍,即种族灭绝、抑郁和基于性别的暴力的长期后果,以及后勤问题、消极态度和父母/照顾者支持不足。初步数据强调了文化适应、创伤知情的认知行为疗法(TI-CBT)在减少卢旺达青年和成年人的抑郁和创伤性痛苦方面的效用。该项目提出了一项双臂随机对照试验,以测试和比较依从性增强型TI-CBT(即TI-CBTe)与常规护理在提高350名卢旺达14-21岁青少年抗逆转录病毒治疗依从性方面的效果,这两家诊所照顾的卢旺达艾滋病毒感染青年人数最多。根据土著领导人外联模式,我们将培训20名艾滋病毒+土著青年领导人,他们是&>95%的抗逆转录病毒药物(ART;)信徒(IYL),并监督心理学家提供干预。青年、照顾者和国际青年会将完成基线、6个月和12个月的后续评估,以评估对坚持和重要调解人(创伤、抑郁、基于性别的暴力)的影响。我们将使用意向处理分析和回归技术的组合以及其他推论统计检验来对比平均数和比例。我们将使用Logistic和线性多元回归模型来分析治疗结果,分别检查6个月和12个月的效果,以及一个具有随机影响的组合模型,用于跨时间重复测量。这项建议满足了对创新项目的迫切需求,以提高HIV+青年对抗逆转录病毒治疗的依从性。如果有效,这项研究将建设卢旺达提供急需服务的能力;卢旺达生物医学中心的参与将确保广泛传播。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Mardge H Cohen其他文献
Commentary: Undocumented women: Pushed from poverty and conflict, pulled into unjust disparity
- DOI:
10.1057/jphp.2009.34 - 发表时间:
2009-12-23 - 期刊:
- 影响因子:1.900
- 作者:
Mardge H Cohen - 通讯作者:
Mardge H Cohen
Mardge H Cohen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Mardge H Cohen', 18)}}的其他基金
MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS) - OAR Sleep Supplement
MACS/WIHS 联合队列研究:库克县临床研究中心 (CC_CRS) - OAR 睡眠补充剂
- 批准号:
10658775 - 财政年份:2019
- 资助金额:
$ 46.2万 - 项目类别:
MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)
MACS/WIHS 联合队列研究:库克县临床研究中心 (CC_CRS)
- 批准号:
10371199 - 财政年份:2019
- 资助金额:
$ 46.2万 - 项目类别:
MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)
MACS/WIHS 联合队列研究:库克县临床研究中心 (CC_CRS)
- 批准号:
10223772 - 财政年份:2019
- 资助金额:
$ 46.2万 - 项目类别:
MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)
MACS/WIHS 联合队列研究:库克县临床研究中心 (CC_CRS)
- 批准号:
10612744 - 财政年份:2019
- 资助金额:
$ 46.2万 - 项目类别:
MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)
MACS/WIHS 联合队列研究:库克县临床研究中心 (CC_CRS)
- 批准号:
10401710 - 财政年份:2019
- 资助金额:
$ 46.2万 - 项目类别:
MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)
MACS/WIHS 联合队列研究:库克县临床研究中心 (CC_CRS)
- 批准号:
9903477 - 财政年份:2019
- 资助金额:
$ 46.2万 - 项目类别:
Improving Adherence Among HIV+ Rwandan Youth: A TI-CBTe Indigenous Leader Model
提高艾滋病毒卢旺达青年的依从性:TI-CBTe 土著领袖模型
- 批准号:
8432149 - 财政年份:2013
- 资助金额:
$ 46.2万 - 项目类别:
Improving Adherence Among HIV+ Rwandan Youth: A TI-CBTe Indigenous Leader Model
提高艾滋病毒卢旺达青年的依从性:TI-CBTe 土著领袖模型
- 批准号:
8978312 - 财政年份:2013
- 资助金额:
$ 46.2万 - 项目类别:
Women's Interagency HIV Study (WIHS) IV, Chicago Consortium
妇女机构间艾滋病毒研究 (WIHS) IV,芝加哥联盟
- 批准号:
8147902 - 财政年份:2010
- 资助金额:
$ 46.2万 - 项目类别:
Women's Interagency HIV Study (WIHS) IV, Chicago Consortium
妇女机构间艾滋病毒研究 (WIHS) IV,芝加哥联盟
- 批准号:
7919681 - 财政年份:2009
- 资助金额:
$ 46.2万 - 项目类别:
相似海外基金
Psychosocial factors as potential moderators of the association between prenatal stress from the Fort McMurray wildfire and social emotional development in 5-6 year old children
心理社会因素作为麦克默里堡野火产前压力与 5-6 岁儿童社会情绪发展之间关系的潜在调节因素
- 批准号:
467237 - 财政年份:2021
- 资助金额:
$ 46.2万 - 项目类别:
Studentship Programs
Mechanisms of Sustained Selective Attention in 2- to 6- Year-Old Children
2至6岁儿童持续选择性注意力的机制
- 批准号:
7739271 - 财政年份:2009
- 资助金额:
$ 46.2万 - 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
- 批准号:
7627037 - 财政年份:2009
- 资助金额:
$ 46.2万 - 项目类别:
Mechanisms of Sustained Selective Attention in 2- to 6- Year-Old Children
2至6岁儿童持续选择性注意力的机制
- 批准号:
7921601 - 财政年份:2009
- 资助金额:
$ 46.2万 - 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
- 批准号:
8037547 - 财政年份:2009
- 资助金额:
$ 46.2万 - 项目类别:
Stage 1 Treatment Development with Homeless Mothers and their 2-6 Year Old Childr
无家可归的母亲及其 2-6 岁儿童的第一阶段治疗发展
- 批准号:
8035834 - 财政年份:2009
- 资助金额:
$ 46.2万 - 项目类别: