Women's Interagency HIV Study (WIHS) IV, Chicago Consortium

WIHS是一项多地点前瞻性流行病学队列研究，研究对象为1994年和2002年登记的女性 要么感染艾滋病毒，要么感染艾滋病毒的风险增加。研究的目的是 继续WIHS队列的后续行动，从而支持对艾滋病毒自然和治疗历史的研究 美国有代表性的、主要是少数民族成年妇女的感染情况，以及支持性研究 新出现的与艾滋病毒长期感染和治疗有关的问题。WIHS-IV科学倡议将 包括正在进行的核心研究项目和启动关于应对的预测因素的新项目 抗逆转录病毒治疗和艾滋病毒感染的长期后果以及艾滋病毒治疗 心血管疾病、肝脏疾病、激素功能、神经认知障碍、癌症和其他 疾病，以及发展为艾滋病和死亡。此外，在WIHS-IV赠款周期中，科学 合作将继续扩大独立的、由研究人员驱动的研究拨款。 作为一项正在进行的队列研究，芝加哥网站将继续支持整个WIHS科学 继续从参与者那里收集高质量的数据和样本，并保持卓越的研究议程 队列保留。芝加哥的网站还将领导包括艾滋病毒病毒学在内的主要感兴趣的领域 和宿主免疫学，HIV感染的长期发病机制和治疗毒性，以及病毒的影响 抵抗。研究的主题将包括丙型肝炎病毒和乙肝病毒等混合感染的影响。 (乙肝病毒)，人类乳头瘤病毒(HPV)；妇女的治疗使用和治疗效果，行为和 影响HIV疾病的心理社会因素、代谢异常的影响、激素因素的影响 关于艾滋病毒疾病；老龄化和更年期对艾滋病毒疾病的影响；环境和环境的相互作用 宿主遗传因素对艾滋病毒疾病的影响；以及对大脑结构、神经认知功能和 WIHS参与者的身体损伤情况。

The WIHS is a multi-site prospective epidemiology cohort study of women enrolled in 1994and 2002 who either are infected with HIV or are at increased risk for acquiring HIV infection. The purpose of the study is to continue follow-up of the WIHS cohort, thereby supporting studies of the natural and treated history of HIV infection in representative, primarily minority, adult women in the United States, as well as supporting studies of emerging questions related to long-term HIV infection and treatment. WIHS-IV scientific initiatives will include ongoing core research projects and the initiation of new projects on the predictors of response to antiretroviral therapy and long term consequences of HIV infection and HIV therapy in terms of cardiovascular disease, liver disease, hormonalfunction, neurocognitive impairment, cancer and other morbidities, as well as progression to AIDS and death. Additionally during the WIHS-IV grant cycle scientific collaborations will continue to expand independent, investigator-driven research grants. As an ongoing cohort study that, The Chicago site will continue to support the overall WIHS scientific research agenda by continuing to collect quality data and specimens from participants and maintain superb cohort retention. The Chicago site will also provide leadership for key areas of interest including HIV virology and host immunology, long term pathogenesis of HIV infection and treatment toxicities, and impact of viral resistance. Topics of study will include the effect of co-infections such as hepatitis C (HCV) and B virus (HBV), human papillomavirus (HPV); therapy use and treatment effects in women, behavioral and psychosocial factors influencing HIV disease, effects of metabolic abnormalities, impact of hormonal factors on HIV disease; the effects of aging and menopause on HIV disease, the interaction of environmental and host genetic factors on HIV disease; and the assessment of brain structure, neurocognitive functioning, and physical impairment among WIHS participants.