Device for Measuring Capillary Blood Flow and the Onset of Shock

描述（由申请人提供）：失血性休克的发生是急诊科和创伤中心死亡的主要原因。目前尚无临床可接受的失血性休克发生的定量监测方法。失血性休克死亡是由于毛细血管血流量减少以及身体无法给主要器官供氧造成的。该提案的长期目标是开发一种贴在患者皮肤上的传感器贴片（CBFM），持续监测毛细血管血流，并与其他监测器结合预测失血性休克的发生。该传感器基于漫相关光谱 (DCS)。 DCS 测量血细胞在毛细血管床中移动时红色或近红外 (NIR) 光散射的波动。 DCS 使用相关分析来提取平均血流速度的特征时间常数。该设备还可以监测心率、动脉或静脉血流量以及血氧。该提案的目的是：1 - 设计和构建原型 CBFM，2 - 展示原型设备测量猪毛细血管血流量的能力，并确定毛细血管血流量测量是否是失血性休克（低血容量）发生的良好早期指标，3 - 创建第二阶段原型的初步设计，4 - 撰写最终报告和第二阶段提案。 公共卫生相关性：失血性休克的发生是急诊科和创伤中心死亡的主要原因。目前尚无临床可接受的失血性休克发生的定量监测方法。失血性休克死亡是由于毛细血管血流量减少以及身体无法给主要器官供氧造成的。该提案的目标是开发一种贴在患者皮肤上的传感器贴片，持续监测毛细血管血流，并与其他监测器结合预测失血性休克的发生。

DESCRIPTION (provided by applicant): The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The long-term goal of this proposal is to develop a sensor patch (CBFM) that attaches to a patient's skin and continuously monitors capillary blood flow and, in conjunction with other monitors, predicts the onset of hemorrhagic shock. The sensor is based upon diffuse correlation spectroscopy (DCS). DCS measures fluctuations in red or near-infrared (NIR) light scattering as blood cells move in the capillary bed. Using correlation analysis, DCS extracts the characteristic time constants due to mean blood flow velocity. The device can also monitor heart rate, arterial or venal blood flow, and blood oxygenation. The aims of the proposal are: 1 - Design and build a prototype CBFM, 2- Demonstrate the ability of the prototype device to measure capillary blood flow in pigs and determine whether capillary blood flow measurements are a good early indicator of the onset of hemorrhagic shock (hypovolemia), 3 - Create initial design of Phase II prototype, 4 - Write final report and Phase II proposal. PUBLIC HEALTH RELEVANCE: The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The goal of this proposal is to develop a sensor patch that attaches to a patient's skin and continuously monitors capillary blood flow and, in conjunction with other monitors, predicts the onset of hemorrhagic shock.