Device for Measuring Capillary Blood Flow and the Onset of Shock

测量毛细血管血流量和休克发生的装置

• 批准号: 8198276
• 负责人: David E. Wolf
• 金额: $ 22.06万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-06 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8198276
• 关键词: Accident and Emergency department; Algorithms; Animal Model; Blood; Blood Cells; Blood Flow Velocity; Blood Pressure Monitors; Blood Vessels; Blood capillaries; Blood flow; Cardiac Output; Catheters; Cause of Death; Cessation of life; Characteristics; Clinical; Collaborations; Complex; Consultations; Coupling; Critical Care; Device Designs; Devices; Diffuse; Emergency Medicine; Emergency Situation; Failure; Family suidae; Fiber; Fiber Optics; Goals; Gold; Heart Rate; Hemorrhage; Hemorrhagic Shock; Hospitals; Hour; Hypovolemia; Hypoxia; Lead; Life; Lung; Measures; Medicine; Methods; Military Personnel; Modeling; Monitor; Operative Surgical Procedures; Organ; Organ failure; Outcome; Patients; Perfusion; Phase; Physicians; Physiologic pulse; Physiological; Physiological Processes; Plastics; Reporting; Reproducibility; Sepsis; Shock; Signal Transduction; Skin; Spectrum Analysis; Testing; Thermodilution; Time; Tissues; Trauma; Work; Writing; base; blood flow measurement; capillary; capillary bed; design; design and construction; improved; light scattering; monitoring device; mortality; prototype; sensor; trauma centers

DESCRIPTION (provided by applicant): The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The long-term goal of this proposal is to develop a sensor patch (CBFM) that attaches to a patient's skin and continuously monitors capillary blood flow and, in conjunction with other monitors, predicts the onset of hemorrhagic shock. The sensor is based upon diffuse correlation spectroscopy (DCS). DCS measures fluctuations in red or near-infrared (NIR) light scattering as blood cells move in the capillary bed. Using correlation analysis, DCS extracts the characteristic time constants due to mean blood flow velocity. The device can also monitor heart rate, arterial or venal blood flow, and blood oxygenation. The aims of the proposal are: 1 - Design and build a prototype CBFM, 2- Demonstrate the ability of the prototype device to measure capillary blood flow in pigs and determine whether capillary blood flow measurements are a good early indicator of the onset of hemorrhagic shock (hypovolemia), 3 - Create initial design of Phase II prototype, 4 - Write final report and Phase II proposal. PUBLIC HEALTH RELEVANCE: The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The goal of this proposal is to develop a sensor patch that attaches to a patient's skin and continuously monitors capillary blood flow and, in conjunction with other monitors, predicts the onset of hemorrhagic shock.

描述（由申请人提供）：失血性休克的发作是急诊科和创伤中心死亡的主要原因。目前临床上还没有公认的失血性休克发病的定量监测方法。失血性休克导致的死亡是由于毛细血管血流减少，导致身体主要器官缺氧。这项提议的长期目标是开发一种传感器贴片（CBFM），它附着在病人的皮肤上，持续监测毛细血管血流，并与其他监测器一起预测失血性休克的发生。该传感器基于漫射相关光谱（DCS）。DCS测量红细胞在毛细血管床上移动时红光或近红外（NIR）光散射的波动。通过相关分析，提取平均血流速度的特征时间常数。该设备还可以监测心率、动脉或静脉血流量以及血液氧合。该提案的目的是：1 -设计并建立一个原型CBFM， 2-展示原型设备测量猪毛细血管血流的能力，并确定毛细血管血流测量是否是失血性休克（低血容量）发作的良好早期指标，3 -创建第二期原型的初步设计，4 -撰写最终报告和第二期提案。