Device for Measuring Capillary Blood Flow and the Onset of Shock

描述(申请人提供)：失血性休克的发作是急诊科和创伤中心死亡的主要原因。目前尚无临床公认的失血性休克发病的定量监测方法。失血性休克死亡的原因是毛细血管血流量减少，导致身体不能给主要器官供氧。这项提议的长期目标是开发一种传感器贴片(CBFM)，这种贴片可以附着在患者的皮肤上，持续监测毛细血管血流，并与其他监测器一起预测失血性休克的发生。该传感器是基于漫相关光谱分析的。分布式控制系统测量血细胞在毛细血管床中移动时的红色或近红外(NIR)光散射的波动。利用相关分析方法，提取由平均血流速度引起的特征时间常数。该设备还可以监测心率、动脉或静脉血流量以及血液氧合。该提案的目的是：1-设计和建造CBFM原型，2-展示原型设备测量猪的毛细血管血流的能力，并确定毛细血管血流测量是否是失血性休克(低血容量)发病的良好早期指标，3-创建第二阶段原型的初步设计，4-撰写最终报告和第二阶段提案。 公共卫生相关性：失血性休克的发作是急诊科和创伤中心死亡的主要原因。目前尚无临床公认的失血性休克发病的定量监测方法。失血性休克死亡的原因是毛细血管血流量减少，导致身体不能给主要器官供氧。这项提议的目标是开发一种传感器贴片，这种贴片可以附着在患者的皮肤上，持续监测毛细血管血流，并与其他监测器一起预测失血性休克的发生。

DESCRIPTION (provided by applicant): The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The long-term goal of this proposal is to develop a sensor patch (CBFM) that attaches to a patient's skin and continuously monitors capillary blood flow and, in conjunction with other monitors, predicts the onset of hemorrhagic shock. The sensor is based upon diffuse correlation spectroscopy (DCS). DCS measures fluctuations in red or near-infrared (NIR) light scattering as blood cells move in the capillary bed. Using correlation analysis, DCS extracts the characteristic time constants due to mean blood flow velocity. The device can also monitor heart rate, arterial or venal blood flow, and blood oxygenation. The aims of the proposal are: 1 - Design and build a prototype CBFM, 2- Demonstrate the ability of the prototype device to measure capillary blood flow in pigs and determine whether capillary blood flow measurements are a good early indicator of the onset of hemorrhagic shock (hypovolemia), 3 - Create initial design of Phase II prototype, 4 - Write final report and Phase II proposal. PUBLIC HEALTH RELEVANCE: The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The goal of this proposal is to develop a sensor patch that attaches to a patient's skin and continuously monitors capillary blood flow and, in conjunction with other monitors, predicts the onset of hemorrhagic shock.