STRUCTURE/FUNCTION DYNAMICS OF NGF RECEPTORS

NGF 受体的结构/功能动力学

• 批准号: 6319185
• 负责人: David E. Wolf
• 金额: $ 5万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6319185
• 关键词: PC12 cells; biological signal transduction; biophysics; confocal scanning microscopy; conformation; dimer; fluorescence microscopy; fluorescence spectrometry; glycoproteins; growth factor receptors; image processing; immunofluorescence technique; membrane activity; neurotrophic factors; photochemistry; protein engineering; protein structure function; protein tyrosine kinase; radiofluorescent probe; receptor binding; receptor expression; recombinant proteins; stoichiometry

DESCRIPTION (Adapted from applicant's abstract): Nerve growth factor (NGF) is a protein required for the development, maintenance, and repair of the nervous system. There are two NGF receptors, gp75 and the tyrosine kinase TrkA. Both of these receptors can signal separately and they synergize with each other to activate multiple signal transduction pathways. The investigators hypothesize that NGF-induced receptor dimerization and clustering are the initiating These studies may provide a physical basis for NGF receptor signaling and, thereby, aid the development of new approaches for enhancing neuronal survival following trauma or during neurodegenerative disease.

描述（改编自申请人摘要）：神经生长因子（NGF）