Optimization of Kinetics in a Novel Glucose Sensor

新型葡萄糖传感器的动力学优化

• 批准号: 6444219
• 负责人: David E. Wolf
• 金额: $ 38.96万
• 依托单位: SENSOR TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444219
• 关键词: biomedical equipment development; biosensor device; blood glucose; chemical kinetics; clinical biomedical equipment; diabetes mellitus; diagnosis design /evaluation; fluorescence resonance energy transfer; laboratory mouse; laboratory rat; measurement; optics; patient monitoring device; portable biomedical equipment

DESCRIPTION (provided by applicant): This Phase II SBIR involves the testing of a minimally invasive glucose sensor in vivo. Diabetes is an increasingly common lifelong disease and is associated with many complications. It is responsible for an estimated 10-15 percent of all health care expenditures. Effective treatment has been shown to prevent or delay many of the associated complications. The most common current treatments include diet, exercise, and self-monitoring of blood glucose (SMBG). An improvement to the current method would enable and encourage patients to monitor their glucose levels more closely and thus improve the general health and quality of life of the diabetic population. The technology is based on a small optical sensor implant that is fluorescent and detectable through the skin. We will finalize the sensor configuration to obtain the fastest kinetics. Animal efficacy trials must be performed to bring the sensor closer to clinical trials in humans. The performance of the sensor will be studied in vivo to demonstrate that the sensor correlates with blood glucose and follows glucose changes in tolerance tests. In vivo testing will be performed to determine the recalibration interval, the reproducibility, and the accuracy of the sensor. The lifetime and biocompatibility of the sensor will also be determined. PROPOSED COMMERCIAL APPLICATION: An improvement in the current method of measuring glucose levels would enable and encourage diabetic patients to measure glucose levels more frequently at home and thus improve the general health and quality of life of the diabetic population. An advance in the glucose sensing technology would greatly impact the diabetes market. A large commercial market currently exists for innovative improvements on glucose detection such as the minimally invasive glucose sensor and accompanying meter described in this research.

描述（由申请人提供）：第二阶段SBIR涉及测试