Non-invasive Blood Alcohol Sensor for Emergency Room Applications

描述(由申请人提供)：急诊室血液酒精的准确定量是准确诊断和迅速治疗的重要筛查步骤。一些严重的紧急情况，如创伤性头部损伤、糖尿病和中风，可能被误诊为酒精中毒。可靠的血液酒精检测将提高这些病例的诊断率。智能光学系统公司计划开发一种用于急诊室(ER)应用的非侵入性酒精传感器，该传感器基于对一种基于Ru的络合物的发射寿命测量。传感器设计将适用于不需要或不需要患者互动和合作的情况。我们的目标是一种简单的光学检测平台，在血液酒精测量中具有高精度，从而实现快速、充分的治疗。这样的系统有望广泛应用于许多卫生保健环境中的临床检测、酒精摄入量筛查和治疗效率监测。这种基于Ru的络合物将以共价方式附着在多孔玻璃基质上。随着唾液采样的发生，酒精分子会与结合的Ru指示剂相互作用，导致发射猝灭。通过使用高度稳定的荧光Ru络合物，将加强通过发射测量进行检测的能力。第一阶段将重点展示实现缓冲液和模拟唾液中酒精水平的可重复性、灵敏测量的可行性。我们将通过与德克萨斯理工大学健康科学中心急诊医学部的罗伯特·伍拉德教授合作，对人类唾液样本进行测试，并与血液水平进行比较。伍拉德教授在酒精、化学和ER相关研究方面是公认的专家。第二阶段将在实际唾液样本中展示传感器的灵敏度和可靠性，以验证检测准确性是否满足ER要求。最终的商业产品将面向医疗诊断、国土安全和临床监测等市场。该系统将有能力扩展到滥用药物的测试，未来的额外研究资金将涵盖ER应用中的多种测试标准。 与公共健康相关：智能光学系统公司建议开发一种新技术，用于在急诊室测量唾液酒精含量。该探测器将具有急诊室所需的测量精度，而不需要患者主动互动，因此将有助于快速诊断和适当的治疗。

DESCRIPTION (provided by applicant): Accurate quantification of blood alcohol in emergency rooms (ERs) is an important screening step for a precise diagnosis and hence for prompt treatment. Some severe emergencies such as traumatic head injury, diabetes, and stroke can be misdiagnosed as alcohol intoxication. A reliable measurement of blood-alcohol would improve diagnosis in these cases. Intelligent Optical Systems proposes to develop a non-invasive sensor for alcohol for emergency room (ER) applications, based on emission lifetime measurements of a ruthenium-based complex. The sensor design will be suitable for situations in which patient interaction and cooperation is not required or is not available. The objective is a simple optical detection platform with high accuracy in blood alcohol measurements, leading to fast, yet adequate treatment. Such a system can be expected to have widespread application for clinical assays in many health care settings, for screening alcohol intake, and for monitoring treatment efficiency. The ruthenium-based complex will be covalently attached to a porous glass matrix. As the saliva sampling occurs, alcohol molecules will interact with bound ruthenium indicator and cause emission quenching. Detection by means of emission measurements will be enhanced by using a highly stable fluorescent ruthenium complex. Phase I will focus on demonstrating the feasibility of achieving reproducible, sensitive measurements of alcohol levels in buffer and modeled saliva. Human saliva samples will be tested and compared to blood levels, through our collaboration with Prof. Robert Woolard of Texas Tech University Health Science Center's Emergency Medicine Department. Prof. Woolard is a recognized expert in alcohol chemical and ER-related studies. Phase II will demonstrate sensor sensitivity and reliability in real saliva samples to validate detection accuracy meeting ER requirements. The final commercial product will address markets such as health care diagnostics, homeland security, and clinical monitoring. The system will have the capability to be extended to testing for drugs of abuse with future additional research funding that will cover multiple testing criteria in ER applications. PUBLIC HEALTH RELEVANCE: Intelligent Optical Systems proposes to develop a new technique for saliva-alcohol measurements in emergency rooms. The detector will have the measurement accuracy required in emergency rooms without the need for active patient interaction, and will therefore contribute to quick diagnosis and appropriate treatment.