Non-invasive Blood Alcohol Sensor for Emergency Room Applications

适用于急诊室应用的无创血液酒精传感器

• 批准号: 8125190
• 负责人: Manal Beshay
• 金额: $ 18.16万
• 依托单位: INTELLIGENT OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-10 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8125190
• 关键词: Accident and Emergency department; Address; Affinity; Alcohol consumption; Alcoholic Intoxication; Alcohols; Binding; Biological Assay; Blood; Blood alcohol level measurement; Body Fluids; Buffers; Chemicals; Clinical; Collaborations; Complex; Craniocerebral Trauma; Detection; Diabetes Mellitus; Diagnosis; Diagnostic; Diffusion; Elements; Emergency Care; Emergency Medicine; Emergency Situation; Ethanol; Evaluation; Funding; Future; Glass; Government; Hand; Health Sciences; Healthcare; Human; Immobilization; Left; Marketing; Measurement; Measures; Metabolic Biotransformation; Methods; Modeling; Monitor; Optics; Patients; Persons; Phase; Protocols documentation; Reporting; Research; Ruthenium; Saliva; Sampling; Screening procedure; Security; Stroke; System; Techniques; Testing; Texas; Time; Universities; Urine; Water; Work; alcohol measurement; alcohol monitoring; alcohol screening; artist; base; clinical application; compliance behavior; design; detector; drug of abuse; improved; meetings; sensor; tool

DESCRIPTION (provided by applicant): Accurate quantification of blood alcohol in emergency rooms (ERs) is an important screening step for a precise diagnosis and hence for prompt treatment. Some severe emergencies such as traumatic head injury, diabetes, and stroke can be misdiagnosed as alcohol intoxication. A reliable measurement of blood-alcohol would improve diagnosis in these cases. Intelligent Optical Systems proposes to develop a non-invasive sensor for alcohol for emergency room (ER) applications, based on emission lifetime measurements of a ruthenium-based complex. The sensor design will be suitable for situations in which patient interaction and cooperation is not required or is not available. The objective is a simple optical detection platform with high accuracy in blood alcohol measurements, leading to fast, yet adequate treatment. Such a system can be expected to have widespread application for clinical assays in many health care settings, for screening alcohol intake, and for monitoring treatment efficiency. The ruthenium-based complex will be covalently attached to a porous glass matrix. As the saliva sampling occurs, alcohol molecules will interact with bound ruthenium indicator and cause emission quenching. Detection by means of emission measurements will be enhanced by using a highly stable fluorescent ruthenium complex. Phase I will focus on demonstrating the feasibility of achieving reproducible, sensitive measurements of alcohol levels in buffer and modeled saliva. Human saliva samples will be tested and compared to blood levels, through our collaboration with Prof. Robert Woolard of Texas Tech University Health Science Center's Emergency Medicine Department. Prof. Woolard is a recognized expert in alcohol chemical and ER-related studies. Phase II will demonstrate sensor sensitivity and reliability in real saliva samples to validate detection accuracy meeting ER requirements. The final commercial product will address markets such as health care diagnostics, homeland security, and clinical monitoring. The system will have the capability to be extended to testing for drugs of abuse with future additional research funding that will cover multiple testing criteria in ER applications. PUBLIC HEALTH RELEVANCE: Intelligent Optical Systems proposes to develop a new technique for saliva-alcohol measurements in emergency rooms. The detector will have the measurement accuracy required in emergency rooms without the need for active patient interaction, and will therefore contribute to quick diagnosis and appropriate treatment.

描述（由申请人提供）：在急诊室（ER）中准确定量血液酒精是精确诊断的重要筛选步骤，因此可以及时治疗。一些严重的紧急情况，如创伤性脑损伤，糖尿病和中风，可能被误诊为酒精中毒。一个可靠的血液酒精测量将提高这些情况下的诊断。智能光学系统公司提出开发一种非侵入式传感器，用于急诊室（ER）的酒精应用，其基础是对基于铍的复合物的发射寿命测量。传感器设计将适用于不需要或无法获得患者互动和合作的情况。其目标是一个简单的光学检测平台，在血液酒精测量中具有高精度，从而实现快速而充分的治疗。这样的系统可以预期在许多医疗保健环境中具有广泛的临床测定应用，用于筛选酒精摄入量，以及用于监测治疗效率。基于铼的复合物将共价连接到多孔玻璃基质。当唾液取样发生时，酒精分子将与结合的钌指示剂相互作用并引起发射猝灭。通过发射测量的检测将通过使用高度稳定的荧光钌络合物来增强。第一阶段将重点展示实现缓冲液和模拟唾液中酒精水平的可重复、灵敏测量的可行性。通过我们与德克萨斯理工大学健康科学中心急诊医学部的Robert Woolard教授的合作，将对人类唾液样本进行测试并与血液水平进行比较。Woolard教授是酒精化学和ER相关研究的公认专家。第二阶段将在真实的唾液样本中证明传感器的灵敏度和可靠性，以验证检测精度是否满足ER要求。最终的商业产品将面向医疗诊断、国土安全和临床监测等市场。该系统将有能力扩展到测试药物滥用与未来的额外研究资金，将涵盖多种测试标准的ER应用。 公共卫生相关性：智能光学系统提出开发一种新技术，用于急诊室的唾液酒精测量。该探测器将具有急诊室所需的测量精度，而无需主动与患者互动，因此将有助于快速诊断和适当治疗。