Center for CAM Research on Autoimmune and Inflammatory Diseases

自身免疫和炎症疾病 CAM 研究中心

• 批准号: 7921617
• 负责人: Prakash S Nagarkatti
• 金额: $ 123.91万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921617
• 关键词: Center; CAM; Research; Autoimmune; Inflammatory

DESCRIPTION (provided by applicant): The Center for CAM Research on Inflammatory and Autoimmune Diseases aims to study the mechanistic basis of preventive and therapeutic modalities developed from plant products against inflammatory and autoimmune disorders. Autoimmune diseases are highly prevalent world-wide. These include arthritis, lupus, autoimmune hepatitis and multiple sclerosis which are mediated primarily by T cells and cause significant chronic disability. In addition, there are also a large number of inflammatory diseases that mimic autoimmune diseases, with unknown etiopathogenesis such as colitis. In the absence of effective medication which can suppress T cells and inflammatory immune response, patients often seek CAM therapy. Thus, the primary goal of the project will be to address 3 specific aims using state-of-the-art technology and an integrated approach which include 1) Studies on ligation of the AhR and ER in the use of resveratrol for the treatment of multiple sclerosis using the experimental autoimmune encephalomyelitis model, 2) Effects of American ginseng as an anti-inflammatory agent in treating colitis and colitis-driven colon cancer. 3) Elucidation of the mechanism(s) underlying cannabidiol-induced apoptosis in therapy of autoimmune hepatitis. Inasmuch as, inflammatory and autoimmune diseases are triggered by multiple factors but exhibit the common pathogenesis of immune cells destroying self-tissues/organs, the efficacy of current treatment regimen include immunosuppressive or anti-inflammatory drugs. Unfortunately, the current drugs in market cause significant toxicity to the immune and cardiovascular systems thereby limiting their use. Thus, CAM herbal therapy or novel compounds derived from plants may provide unique opportunity to treat such diseases. These studies should lead to development of translational research that extends between the Schools of Medicine, Nursing, Public Health at USC and the Dorn VA Medical Center. The project will use an Administrative Core and an Immunotoxicology Laboratory Core. The Administrative Core will provide scientific leadership including the External Scientific Advisory Committee, the Internal Advisory Committee and Steering Committee, mentorship to junior faculty, post- and predoctoral trainees as well as oversight on fiscal, personnel, and space issues. The Immunotoxicology Laboratory Core will not only serve as a source of the instrumentation resource for pursuing cutting-edge research on whole animals through single cell imaging to molecular level analysis, along with the technological support, but also perform immunotoxicity testing of the plant products. The university will provide seed funds for developmental projects in CAM and enhance recruitment of junior faculty and trainees. The establishment of this Center will provide an interactive environment for research and training in elucidating the mechanisms underlying action of CAM as well as meet the state and national goals on development of novel approaches to patient care.

描述（由申请人提供）： CAM 炎症和自身免疫性疾病研究中心旨在研究由植物产品开发的针对炎症和自身免疫性疾病的预防和治疗方式的机制基础。自身免疫性疾病在世界范围内非常流行。这些疾病包括关节炎、狼疮、自身免疫性肝炎和多发性硬化症，这些疾病主要由 T 细胞介导并导致严重的慢性残疾。此外，还有大量类似自身免疫性疾病、病因不明的炎症性疾病，例如结肠炎。在缺乏可以抑制 T 细胞和炎症免疫反应的有效药物的情况下，患者经常寻求 CAM 治疗。因此，该项目的主要目标是利用最先进的技术和综合方法来实现 3 个具体目标，其中包括 1) 使用实验性自身免疫性脑脊髓炎模型研究使用白藜芦醇治疗多发性硬化症时的 AhR 和 ER 结扎，2) 西洋参作为抗炎剂治疗结肠炎和结肠炎引起的结肠癌的效果。 3) 阐明大麻二酚诱导的自身免疫性肝炎治疗中细胞凋亡的机制。由于炎症和自身免疫性疾病是由多种因素引发的，但其共同的发病机制是免疫细胞破坏自身组织/器官，因此目前的治疗方案的功效包括免疫抑制或抗炎药物。不幸的是，目前市场上的药物对免疫和心血管系统造成显着毒性，从而限制了它们的使用。因此，CAM 草药疗法或源自植物的新型化合物可能为治疗此类疾病提供独特的机会。这些研究应该会促进南加州大学医学院、护理学院、公共卫生学院和多恩退伍军人管理局医学中心之间的转化研究的发展。该项目将使用行政核心和免疫毒理学实验室核心。行政核心将提供科学领导，包括外部科学咨询委员会、内部咨询委员会和指导委员会，对初级教师、博士后和博士前学员的指导以及对财务、人事和空间问题的监督。免疫毒理学实验室核心不仅将作为通过单细胞成像到分子水平分析对整个动物进行尖端研究的仪器资源来源以及技术支持，而且还将对植物产品进行免疫毒性测试。该大学将为 CAM 的发展项目提供种子资金，并加强初级教师和实习生的招聘。该中心的建立将为研究和培训提供一个互动环境，以阐明 CAM 的作用机制，并实现州和国家开发新型患者护理方法的目标。