Center for CAM Research on Autoimmune and Inflammatory Diseases

自身免疫和炎症疾病 CAM 研究中心

• 批准号: 7907072
• 负责人: Prakash S Nagarkatti
• 金额: $ 4.8万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907072
• 关键词: Address; Advisory Committees; American; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Apoptosis; Arthritis; Arts; Autoimmune Diseases; Autoimmune Hepatitis; Autoimmune Process; Cannabidiol; Cardiovascular system; Cells; Chronic; Colitis; Colon Carcinoma; Development; Disease; Environment; Exhibits; Experimental Autoimmune Encephalomyelitis; Faculty; Funding; Ginseng Preparation; Goals; Human Resources; Immune; Immune response; Immunosuppressive Agents; Immunotoxicology; Inflammatory; Laboratories; Lead; Leadership; Ligation; Lupus; Marketing; Mediating; Medical center; Mentorship; Modality; Modeling; Molecular; Multiple Sclerosis; Organ; Pathogenesis; Patient Care; Patients; Pharmaceutical Preparations; Phytotherapy; Plants; Preventive; Public Health Nurses; Public Health Nursing; Research; Research Training; Resources; Resveratrol; Seeds; Source; T-Lymphocyte; Technology; Testing; Therapeutic; Tissues; Toxic effect; Translational Research; Treatment Protocols; Universities; base; cellular imaging; disability; immunotoxicity; instrumentation; medical schools; meetings; novel; novel strategies; pre-doctoral

DESCRIPTION (provided by applicant): The Center for CAM Research on Inflammatory and Autoimmune Diseases aims to study the mechanistic basis of preventive and therapeutic modalities developed from plant products against inflammatory and autoimmune disorders. Autoimmune diseases are highly prevalent world-wide. These include arthritis, lupus, autoimmune hepatitis and multiple sclerosis which are mediated primarily by T cells and cause significant chronic disability. In addition, there are also a large number of inflammatory diseases that mimic autoimmune diseases, with unknown etiopathogenesis such as colitis. In the absence of effective medication which can suppress T cells and inflammatory immune response, patients often seek CAM therapy. Thus, the primary goal of the project will be to address 3 specific aims using state-of-the-art technology and an integrated approach which include 1) Studies on ligation of the AhR and ER in the use of resveratrol for the treatment of multiple sclerosis using the experimental autoimmune encephalomyelitis model, 2) Effects of American ginseng as an anti-inflammatory agent in treating colitis and colitis-driven colon cancer. 3) Elucidation of the mechanism(s) underlying cannabidiol-induced apoptosis in therapy of autoimmune hepatitis. Inasmuch as, inflammatory and autoimmune diseases are triggered by multiple factors but exhibit the common pathogenesis of immune cells destroying self-tissues/organs, the efficacy of current treatment regimen include immunosuppressive or anti-inflammatory drugs. Unfortunately, the current drugs in market cause significant toxicity to the immune and cardiovascular systems thereby limiting their use. Thus, CAM herbal therapy or novel compounds derived from plants may provide unique opportunity to treat such diseases. These studies should lead to development of translational research that extends between the Schools of Medicine, Nursing, Public Health at USC and the Dorn VA Medical Center. The project will use an Administrative Core and an Immunotoxicology Laboratory Core. The Administrative Core will provide scientific leadership including the External Scientific Advisory Committee, the Internal Advisory Committee and Steering Committee, mentorship to junior faculty, post- and predoctoral trainees as well as oversight on fiscal, personnel, and space issues. The Immunotoxicology Laboratory Core will not only serve as a source of the instrumentation resource for pursuing cutting-edge research on whole animals through single cell imaging to molecular level analysis, along with the technological support, but also perform immunotoxicity testing of the plant products. The university will provide seed funds for developmental projects in CAM and enhance recruitment of junior faculty and trainees. The establishment of this Center will provide an interactive environment for research and training in elucidating the mechanisms underlying action of CAM as well as meet the state and national goals on development of novel approaches to patient care.

描述（由申请人提供）：炎症和自身免疫性疾病CAM研究中心旨在研究从植物产品开发的预防和治疗炎症和自身免疫性疾病的机制基础。自身免疫性疾病在世界范围内非常普遍。这些疾病包括关节炎、狼疮、自身免疫性肝炎和多发性硬化症，这些疾病主要由T细胞介导，并导致严重的慢性残疾。此外，还有大量类似自身免疫性疾病的炎症性疾病，其病因不明，如结肠炎。在缺乏有效药物抑制T细胞和炎症免疫反应的情况下，患者往往寻求CAM治疗。因此，该项目的主要目标将是利用最先进的技术和综合方法解决3个具体目标，其中包括：1)利用实验性自身免疫性脑脊髓炎模型研究白藜芦醇用于治疗多发性硬化症的AhR和ER结扎研究；2)西洋参作为抗炎剂在治疗结肠炎和结肠炎驱动的结肠癌中的作用。3)阐明大麻二酚诱导细胞凋亡治疗自身免疫性肝炎的机制。由于炎症性和自身免疫性疾病是由多种因素引发的，但其共同的发病机制是免疫细胞破坏自身组织/器官，因此目前的治疗方案包括免疫抑制剂或抗炎药物。不幸的是，目前市场上的药物对免疫系统和心血管系统有明显的毒性，因此限制了它们的使用。因此，CAM草药疗法或从植物中提取的新型化合物可能为治疗此类疾病提供独特的机会。这些研究应该促进南加州大学医学院、护理学院、公共卫生学院和多恩退伍军人医疗中心之间的转化研究的发展。该项目将使用行政核心和免疫毒理学实验室核心。行政核心将提供科学领导，包括外部科学咨询委员会、内部咨询委员会和指导委员会，指导初级教员、博士后和博士生学员，以及监督财政、人事和空间问题。免疫毒理学实验室核心不仅将作为从单细胞成像到分子水平分析的全动物前沿研究的仪器资源来源，以及技术支持，还将进行植物产品的免疫毒性测试。理大将提供种子基金，资助香港中文大学的发展计划，并加强招聘初级教员和实习生。该中心的建立将为研究和培训提供一个互动的环境，以阐明CAM的潜在作用机制，并满足国家和国家在发展新的患者护理方法方面的目标。