Center for Dietary Supplements and Inflammation

膳食补充剂和炎症中心

• 批准号: 8531296
• 负责人: Prakash S Nagarkatti
• 金额: $ 196.18万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531296
• 关键词: Adaptor Signaling Protein; Adhesions; Advisory Committees; American; Anti-Inflammatory Agents; Anti-inflammatory; Antiatherogenic; Area; Arterial Fatty Streak; Atherosclerosis; Attenuated; Autoimmune Diseases; Award; Binding; Blood Vessels; Botanicals; Brain; Cardiovascular Diseases; Cells; Centers of Research Excellence; China; Chinese Herbs; Chinese Traditional Medicine; Chronic; Clinic; Clinical; Clinical Trials; Complement; Complementary and alternative medicine; Core Facility; Data; Deposition; Development; Diet; Disease; Endothelial Cells; Entrepreneurship; Faculty; Fatty acid glycerol esters; Goals; Grant; Heart; Herb; Human; In Vitro; Infiltration; Inflammation; Inflammatory; Inflammatory Response; Interdisciplinary Study; Interleukin-1; Invaded; Investigation; Lead; Leukocytes; Ligands; Lipids; Lipopolysaccharides; Low Density Lipoprotein Receptor; Malignant Neoplasms; Measures; Mediating; Mentors; Modality; Molecular; Mus; Myocardial Infarction; Natural Immunity; Neurodegenerative Disorders; Pathogenesis; Pharmacology; Phenotype; Plants; Play; Proteins; Recruitment Activity; Research; Research Personnel; Research Project Grants; Role; Scientist; Signal Transduction; Smooth Muscle Myocytes; South Carolina; Staging; Stroke; Structure; TLR2 gene; TLR3 gene; TLR4 gene; Testing; Therapeutic; Therapeutic Agents; Tissues; Toll-like receptors; Training; Translational Research; United States; Universities; Vascular Endothelial Cell; Viral; Work; analog; atherogenesis; base; cell motility; dietary supplements; driving force; feeding; hypercholesterolemia; immune function; innovation; macrophage; member; monocyte; novel; oxidized lipid; pathogen; prevent; programs; public health relevance; receptor; vascular inflammation

DESCRIPTION (provided by applicant): This COBRE application proposes to establish a Center for Dietary Supplements and Inflammation (CDSI) at the University of South Carolina (USC) that will pursue multidisciplinary research on how botanicals can modulate inflammation and be used to prevent and/or treat inflammatory diseases. Recently, USC has made significant strides to promote research in Complementary and Alternative Medicine (CAM) which has resulted in the award of a Program Project/Center grant to study CAM modalities to treat autoimmune diseases. Thus, the CDSI will complement the CAM program and create a unique niche at USC in inflammation research. The main goal of CDSI is to establish multi-disciplinary research that will identify the molecular mechanisms through which botanicals modulate inflammation so that they or their analogs can be used to prevent and/or treat inflammatory diseases. Americans spend~$33.9 billion/year on CAM, of which ~$20 billion is on dietary supplements. It is becoming increasingly clear that inflammation plays a critical role in the pathogenesis of not only autoimmune diseases but also a wide range of clinical disorders including cardiovascular diseases, neurodegenerative disorders, and cancer: areas under investigation in this study. Thus, understanding the mode of action of dietary supplements or their constituents on inflammation, could lead to novel treatment modalities with far ranging clinical implications. The CDSI goal will be accomplished through promotion of multi-disciplinary research pursued by 4 junior tenure-track faculty in the area of inflammatory diseases, through highly structured mentoring by eight senior faculty members, and providing them with state-of-the-art core facilities. The program will be evaluated by an External Advisory Committee consisting of nationally recognized scientists. Additionally, through institutional support, 10 new tenure-track junior faculty will be recruited and trained at USC to bolster and advance inflammation research. The long term objective of the CDSI would be to build a self-sustaining, nationally recognized multi-disciplinary Center for dietary supplements and inflammation research, by promoting innovation, faculty entrepreneurship, collaborative research projects (PPGs and Institutional Training grants), and clinical/translational research.

描述（由申请人提供）：本COBRE申请建议在南卡罗来纳州大学（USC）建立膳食补充剂和炎症中心（CDSI），该中心将对植物如何调节炎症并用于预防和/或治疗炎症性疾病进行多学科研究。最近，南加州大学在促进补充和替代医学（CAM）的研究方面取得了重大进展，这导致了一项计划项目/中心赠款的授予，以研究CAM治疗自身免疫性疾病的方式。因此，CDSI将补充CAM计划，并在南加州大学炎症研究中创造一个独特的利基。CDSI的主要目标是建立多学科研究，以确定植物调节炎症的分子机制，以便它们或其类似物可用于预防和/或治疗炎症性疾病。美国人每年在CAM上花费约339亿美元，其中约200亿美元用于膳食补充剂。越来越清楚的是，炎症不仅在自身免疫性疾病的发病机制中起着关键作用，而且在包括心血管疾病、神经退行性疾病和癌症在内的广泛的临床疾病中也起着关键作用：本研究正在研究的领域。因此，了解膳食补充剂或其成分对炎症的作用方式，可能会导致具有广泛临床意义的新型治疗方式。CDSI的目标将通过促进4名初级终身教职员工在炎症性疾病领域进行的多学科研究来实现，通过8名高级教师的高度结构化指导，并为他们提供最先进的核心设施。该计划将由一个由国家认可的科学家组成的外部咨询委员会进行评估。此外，通过机构支助， 南加州大学将招募和培训终身教职的初级教师，以支持和推进炎症研究。CDSI的长期目标是通过促进创新，教师创业，合作研究项目（PPG和机构培训赠款）和临床/转化研究，建立一个自我维持的，国家认可的多学科膳食补充剂和炎症研究中心。