Understanding the Cognitive Impact of Early Life Epilepsy
了解早期癫痫对认知的影响
基本信息
- 批准号:8119615
- 负责人:
- 金额:$ 58.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-30 至 2013-01-16
- 项目状态:已结题
- 来源:
- 关键词:AttenuatedAutistic DisorderBrainClinicalCognitionCognitiveDevelopmentDiseaseEpilepsyEpileptogenesisEventImpaired cognitionInterruptionInterventionLaboratoriesLeadLifeNeonatalNeuronsPatientsPatternPreventionProcessProteinsSeizuresSignal PathwaySignal TransductionStructureSynapsesSynaptic plasticityTechniquesTestingTimeWorkbehavioral impairmenthuman tissueinfancy
项目摘要
Epilepsy is a disorder that involves far more than the occurrence of seizures, and
seizures can cause neuronal network disturbances that result in a wide range of
cognitive and behavioral impairment. To date, most work in the epilepsy field has
centered on the mechanism or prevention of the ictal events themselves. The focus of
my laboratory has been on the impact of early life seizures on brain development and
epileptogenesis. The present proposal extends our work to determine whether these
mechanisms also induce alterations that could lead to cognitive dysfunction manifesting
in early life, such as autism. There is clinical evidence that early life seizures may be one
of many precedents for autism, and epilepsy is common in patients with autism,
suggesting an interaction between the two processes. Our prior and recent work
suggests that at least in the immature brain, where baseline synaptic plasticity is
enhanced, seizures appear to directly activate specific plasticity-associated signaling
pathways. We hypothesize that seizure induced ¿dysplasticity¿ may occlude normal
plasticity involved in cognition, and induce abnormal patterns of synapse development
similar to those observed in autism and other forms of neurodevelopmental delay. Using
electrophysiological techniques, we will first examine the time course of seizure-induced
interruption of normal synaptic plasticity in the immature brain. We will then determine
whether specific activity-dependent signaling abnormalities known to be associated with
autism occur de novo following seizures in the immature brain. Next, we will identify
seizure induced mechanisms for their activation and test whether post-seizure
intervention attenuates the altered structure and function of neuronal networks. Finally,
we will determine whether similar alterations in signaling, regulatory, and synaptic
proteins also are observed in human tissue following seizures and in cases of autism
associated with neonatal or infantile seizures.
癫痫是一种疾病,涉及的远不止癫痫发作的发生,而且
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Frances E Jensen其他文献
Developmental regulation of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortex
前脑α-氨基-3-羟基-5-甲基-4-异恶唑-丙酸受体亚基表达的发育调节及其与缺氧/缺血性损伤的区域易感性的关系II。
- DOI:
- 发表时间:
2006 - 期刊:
- 影响因子:0
- 作者:
Delia M Talos;Pamela L. Follett;R. Folkerth;Rachel Fishman;F. Trachtenberg;J. Volpe;Frances E Jensen - 通讯作者:
Frances E Jensen
Frances E Jensen的其他文献
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{{ truncateString('Frances E Jensen', 18)}}的其他基金
Seizure-induced enhancement of synaptic signaling regulating tau transmissibility in Alzheimer's Disease
癫痫发作诱导的突触信号增强调节阿尔茨海默病中 tau 蛋白的传递性
- 批准号:
10611518 - 财政年份:2022
- 资助金额:
$ 58.47万 - 项目类别:
Seizure-induced enhancement of synaptic signaling regulating tau transmissibility in Alzheimer's Disease
癫痫发作诱导的突触信号增强调节阿尔茨海默病中 tau 蛋白的传递性
- 批准号:
10455852 - 财政年份:2022
- 资助金额:
$ 58.47万 - 项目类别:
The NKCC1 inhibitor bumetanide as a novel therapy in TSC
NKCC1 抑制剂布美他尼作为 TSC 的新型疗法
- 批准号:
8457417 - 财政年份:2012
- 资助金额:
$ 58.47万 - 项目类别:
The NKCC1 inhibitor bumetanide as a novel therapy in TSC
NKCC1 抑制剂布美他尼作为 TSC 的新型疗法
- 批准号:
8554384 - 财政年份:2012
- 资助金额:
$ 58.47万 - 项目类别:
Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
通过 NKCC1 抑制剂减轻氨己烯酸对视网膜和中枢神经系统的不良影响
- 批准号:
7937917 - 财政年份:2009
- 资助金额:
$ 58.47万 - 项目类别:
Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
通过 NKCC1 抑制剂减轻氨己烯酸对视网膜和中枢神经系统的不良影响
- 批准号:
7829070 - 财政年份:2009
- 资助金额:
$ 58.47万 - 项目类别:
Understanding the Cognitive Impact of Early Life Epilepsy
了解早期癫痫对认知的影响
- 批准号:
7341202 - 财政年份:2007
- 资助金额:
$ 58.47万 - 项目类别:
Understanding the Cognitive Impact of Early Life Epilepsy
了解早期癫痫对认知的影响
- 批准号:
8650480 - 财政年份:2007
- 资助金额:
$ 58.47万 - 项目类别:
Understanding the Cognitive Impact of Early Life Epilepsy
了解早期癫痫对认知的影响
- 批准号:
7914219 - 财政年份:2007
- 资助金额:
$ 58.47万 - 项目类别:
Understanding the Cognitive Impact of Early Life Epilepsy
了解早期癫痫对认知的影响
- 批准号:
7681264 - 财政年份:2007
- 资助金额:
$ 58.47万 - 项目类别:
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