OPEN LABEL RISPERIDONE IN CHILDREN AND ADOLESCENTS WITH AUTISTIC DISORDER

开放标签利培酮用于患有自闭症的儿童和青少年

• 批准号: 7953733
• 负责人: ALEXANDER KOLEVZON
• 金额: $ 0.02万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953733
• 关键词: Adolescent; Autistic Disorder; Behavior; Behavioral; Behavioral Symptoms; Child; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; DSM-IV; Diagnostic; Disease; Dopamine; FDA approved; Functional disorder; Funding; Grant; Institution; Interview; Neurons; Pharmaceutical Preparations; Problem behavior; Research; Research Design; Research Personnel; Resources; Risperidone; Serotonin; Source; Symptoms; System; United States National Institutes of Health; atypical antipsychotic; open label

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis: This study is a multicenter, open-label study designed to assess the efficacy of risperidone in reducing irritability and associated behaviors displayed by children and adolescents who fulfill DSM-IV and Autism Diagnostic Interview (ADI) criteria. Although behavioral and educational therapies and a variety of medications may help manage some symptoms of autism, there are no FDA-approved treatments for the disorder. However, atypical antipsychotics have emerged as promising therapies for the behavioral symptoms of Autistic Disorder. Risperidone, the most rigorously studied of the atypical antipsychotics, is effective for serious behavioral problems in Autistic Disorder as it has potent effects on the dopamine and 5-HT neuronal systems, both of which have been implicated in the pathophysiology of autism

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设： 本研究是一项多中心、开放标签研究，旨在评估利培酮在减少符合DSM-IV和自闭症诊断访谈（ADI）标准的儿童和青少年表现出的易怒和相关行为方面的疗效。 虽然行为和教育疗法以及各种药物可能有助于控制自闭症的一些症状，但FDA还没有批准这种疾病的治疗方法。 然而，非典型抗精神病药物已经成为自闭症行为症状的有希望的治疗方法。 利培酮是目前研究最深入的非典型抗精神病药物，对自闭症患者的严重行为问题有效，因为它对多巴胺和5-HT神经元系统具有强效作用，而多巴胺和5-HT神经元系统均与自闭症的病理生理有关