MOLECULAR TARGETS FOR AA PROSTATE CANCER PATIENTS USING MIRNA PROFILING

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该提案的总体目标是检验以下假设：非洲裔美国人与高加索人男性中miRNA的差异表达有助于在整个前列腺癌进展过程中对基因表达进行表观遗传调控，并且这种调控受到肿瘤微环境的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this proposal is to test the hypothesis that differential expression of miRNA in African American vs Caucasian males contributes to the epigenetic regulation of gene expression throughout prostate cancer progression, and that this regulation is influenced by the tumor microenvironment.