MOLECULAR TARGETS FOR AA PROSTATE CANCER PATIENTS USING MIRNA PROFILING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项建议的总体目标是检验这样一种假设，即非裔美国人和白人男性中miRNA的差异表达有助于前列腺癌进展过程中基因表达的表观遗传调节，并且这种调节受到肿瘤微环境的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this proposal is to test the hypothesis that differential expression of miRNA in African American vs Caucasian males contributes to the epigenetic regulation of gene expression throughout prostate cancer progression, and that this regulation is influenced by the tumor microenvironment.