Project 2: Molecular Regulation of Kaiso in Prostate Cancer
Project 2: Molecular Regulation of Kaiso in Prostate Cancer
批准号:
9211123
负责人:
Clayton Yates
金额:
$12.94万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
未结题
起止时间:
2005-09-30 至
关键词:
African AmericanAlabamaAndrogensApoptosisBindingCancer Death RatesCancer PatientCastrationCell Cycle ArrestCell NucleusCell ProliferationCellsCessation of lifeDNA MethylationDevelopmentDiagnosticDiseaseE-CadherinEpidermal Growth Factor ReceptorEpigenetic ProcessEvaluationGene DeletionGenesGeneticIndolentInstitutionInvestigationLinkMalignant Epithelial CellMalignant neoplasm of prostateMediatingMethylationMolecularMorehouse School of MedicineMusNeoplasm MetastasisNuclearPatientsPeptidesPhenotypePrimary NeoplasmProstate AdenocarcinomaProteinsReceptor SignalingRegulationRepressor ProteinsResistanceRoleSecondary toSignal TransductionTestingTherapeuticUniversitiesXenograft Modelautocrinebasecancer diagnosischromatin immunoprecipitationdesignepithelial to mesenchymal transitioninhibitor/antagonistmalenovelpre-clinicalpreventprognosticprostate cancer cell lineprotein protein interactiontumortumor growth
中文摘要
7.项目总结/摘要
虽然前列腺腺癌是美国男性中最常见的癌症,
比预期的要低患有前列腺癌(PCa)的非洲裔美国人(AAs)
通常有更积极的疾病,并弥补了不成比例的死亡人数,
疾病;然而,许多患有PCa的患者即使未经治疗也不会死于PCa(即,惰性前列腺
癌症)。我们最近研究了分子Kaiso在PCa中的表达,发现Kaiso在PCa中的表达与PCa的表达相关。
积极的PCa增加,尤其是在AAs的PCa。另外,我们发现Kaiso参与了
促进基因的表观遗传抑制(例如,E-钙粘蛋白),并通过这种特定基因的沉默,
导致上皮细胞向间质细胞转化(EMT)和前列腺癌的雄激素抗性。我们的目标
该提案旨在证明Kaiso的核表达是通过EGFR信号传导介导的,
Kaiso可以在治疗上靶向减少EMT和相关的PCa转移。完成
为此,我们概述了三个具体目标。
英文摘要
7. PROJECT SUMMARY/ABSTRACT
Although prostatic adenocarcinoma is the most commonly diagnosed cancer in U.S. males, the death rate
from this cancer is lower than would be expected. African Americans (AAs) who have prostate cancer (PCa)
typically have more aggressive disease and make up a disproportionate number of the deaths from this
disease; however, many patients with PCa will not die of PCa even if untreated (i.e., indolent prostate
cancer). We have recently studied the expression of the molecule, Kaiso, in PCa and found that Kaiso is
increased in aggressive PCa, especially in PCa in AAs. Also, we have found that Kaiso is involved in
facilitating the epigenetic suppression of genes (e.g., E-cadherin), and via this silencing of specific genes,
causing epithelial to mesenchymal transition (EMT) and androgen resistance of PCa. The objectives of our
proposal are to demonstrate that the nuclear expression of Kaiso is mediated through EGFR signaling and
that Kaiso can be targeted therapeutically to reduce EMT and associated metastases of PCa. To accomplish
this, we have outlined three specific aims.
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会议论文
ADMIN CORE
-
批准号:9360287
-
项目类别:
-
资助金额:$7.05万
-
财政年份:2014
-
负责人:Clayton Yates
-
依托单位:
Transcriptional Regulation of Breast Cancer Metastasis within the Tumor Microenvi
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批准号:8774426
-
项目类别:
-
资助金额:$17.4万
-
财政年份:2014
-
负责人:Clayton Yates
-
依托单位:
INFRASTRUCTURE CORE I: SHAREABLE INSTRUMENTATION FACILITY
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批准号:9360288
-
项目类别:
-
资助金额:$20.77万
-
财政年份:2014
-
负责人:Clayton Yates
-
依托单位:
Transcriptional Regulation of Breast Cancer Metastasis within the Tumor Microenvi
-
批准号:8919859
-
项目类别:
-
资助金额:$19.43万
-
财政年份:2014
-
负责人:Clayton Yates
-
依托单位:
MOLECULAR TARGETS FOR AA PROSTATE CANCER PATIENTS USING MIRNA PROFILING
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批准号:8357143
-
项目类别:
-
资助金额:$8.65万
-
财政年份:2011
-
负责人:Clayton Yates
-
依托单位:
Administrative Core
-
批准号:10328023
-
项目类别:
-
资助金额:$25.97万
-
财政年份:2005
-
负责人:Clayton Yates
-
依托单位:
Research Education Core
-
批准号:10251976
-
项目类别:
-
资助金额:$3.32万
-
财政年份:2005
-
负责人:Clayton Yates
-
依托单位:
Administrative Core
-
批准号:10491176
-
项目类别:
-
资助金额:$25.62万
-
财政年份:2005
-
负责人:Clayton Yates
-
依托单位:
Research Education Core
-
批准号:10016088
-
项目类别:
-
资助金额:$23.71万
-
财政年份:2005
-
负责人:Clayton Yates
-
依托单位:
1/2 Morehouse Sch of Medicine/Tuskegee Univ/University of Alabama Ca Ctr Partnership
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批准号:10016078
-
项目类别:
-
资助金额:$19.28万
-
财政年份:2005
-
负责人:Clayton Yates
-
依托单位:
1/2 Morehouse Sch of Medicine/Tuskegee Univ/University of Alabama Ca Ctr Partnership
-
批准号:10251970
-
项目类别:
-
资助金额:$3.32万
-
财政年份:2005
-
负责人:Clayton Yates
-
依托单位:
Administrative Core
-
批准号:10701934
-
项目类别:
-
资助金额:$25.62万
-
财政年份:2005
-
负责人:Clayton Yates
-
依托单位:
Tuskegee University Center for Biomedical Research/ Research Centers at Minority Institutions
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批准号:10194584
-
项目类别:
-
资助金额:$177.29万
-
财政年份:1997
-
负责人:Clayton Yates
-
依托单位:
Administrative Core
-
批准号:10194599
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项目类别:
-
资助金额:$35.76万
-
财政年份:1997
-
负责人:Clayton Yates
-
依托单位:
Investigator Development Core
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批准号:10194601
-
项目类别:
-
资助金额:$42.99万
-
财政年份:1997
-
负责人:Clayton Yates
-
依托单位:
Administrative Core
-
批准号:10495204
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1997
-
负责人:Clayton Yates
-
依托单位:
Center for Rural Health and Economic Disparities Research
-
批准号:10195100
-
项目类别:
-
资助金额:$18.03万
-
财政年份:1997
-
负责人:Clayton Yates
-
依托单位:
Administrative Core
-
批准号:10809405
-
项目类别:
-
资助金额:$107.07万
-
财政年份:1997
-
负责人:Clayton Yates
-
依托单位:
Administrative Core
-
批准号:10220202
-
项目类别:
-
资助金额:$18.03万
-
财政年份:1997
-
负责人:Clayton Yates
-
依托单位:
Administrative Core
-
批准号:10709936
-
项目类别:
-
资助金额:$48.51万
-
财政年份:1997
-
负责人:Clayton Yates
-
依托单位:
海外基金