Coronary Vessel Development, Adaptation and Therapeutic Interventions

冠状动脉的发育、适应和治疗干预

• 批准号: 8112004
• 负责人: ROBERT J TOMANEK
• 金额: $ 5万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2013-10-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8112004
• 关键词: Address; Adult; Affect; Aging; Aging-Related Process; Animal Model; Animals; Archives; Area; Basic Science; Biology; Blood Vessels; Blood capillaries; Blood flow; Books; Brain Hypoxia-Ischemia; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cartoons; Chronic; Clinic; Collection; Community Healthcare; Conflict (Psychology); Contracts; Coronary; Coronary Arteriosclerosis; Coronary Vessels; Data; Development; Disease; Embryo; Exercise; Experimental Animal Model; Goals; Growth; Health; Heart; Human; Hypertension; Hypertrophy; Image; Individual; Institutes; Laboratories; Link; Literature; Medicine; Metabolism; Microscopic; Molecular; Monograph; Morbidity - disease rate; Mus; Museums; Myocardial Ischemia; Myocardium; Organ; Oryctolagus cuniculus; Outcome; Oxygen; Paper; Pathology; Postdoctoral Fellow; Publications; Publishing; Rattus; Research; Scientist; Slide; Source; Stress; Therapeutic Intervention; Trees; United States; United States National Institutes of Health; Vascularization; Work; Writing; animal data; arm; capillary; coronary perfusion; density; graduate student; insight; interest; mortality; new technology; postnatal; prevent; response; senescence; sound; therapeutic angiogenesis

DESCRIPTION (provided by applicant): The fact that ischemic heart disease is the leading cause of morbidity and mortality in the industrial world highlights the importance of the coronary vasculature. This proposal considers the importance of coronary vessel growth as essential, not only during early development, but also in the adult heart faced with various stresses, e.g. hypertrophy, ischemia, hypoxia and chronic exercise. Moreover, the recent exponential increase in studies on therapeutic angiogenesis, many of which are conflicting, suggests that we need to develop a sound understanding of the factors and mechanisms that govern coronary vessel formation. However, existing compilations of these data remain limited to books focusing on specific areas of the coronary vasculature. Thus, there is no single comprehensive work that brings these individual topics together. As a scientist who has conducted research and written reviews addressing many of the areas of coronary vessel research, the PI has the unique background necessary to bring these topics together into a comprehensive monograph. The overall goal of this application is to write a monograph that considers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood and senescence. This critical review will consider the coronary vasculature with regard to its 1) normal development, 2) anomalies and their possible underlying developmental errors, 3) adaptations to stress (e.g. hypertension, hypoxia and ischemia), and 4) aging. The monograph will be timely because novel technologies have enabled the discovery of molecular mechanisms underlying the assembly and growth of the coronary vasculature and adaptations and alterations that occur in the adult. In addition to utilizing the existing literature, data from archives on human embryos and on models of experimental animals will be incorporated. The book will explore and critically analyze the literature and relate data from experimental animals to the human condition. Images will be included in the book and an expanded version will be on-line. By integrating these areas, clinicians and basic scientists may gain important insights into the interrelationships between different areas of coronary vascular biology. The monograph is intended for at least three groups. First, a major target audience is comprised of all scientists, postdoctoral fellows and graduate students who are in any of the areas of coronary vascular biology. For this audience, the monograph should serve as both a key reference and a source for broadening their understanding of the diversity of the vascular biology field. A second targeted group consists of vascular biologists whose primary interest is in mechanisms of vascular development, in general, and those individuals whose interest is in the vascularization of organs other than the heart. The third targeted group is clinicians who should find the monograph to be a beneficial reference source and overview.

描述（由申请人提供）： 缺血性心脏病是工业界发病和死亡率的主要原因，这一事实凸显了冠状动脉脉管系统的重要性。该提议认为冠状血管生长的重要性是必不可少的，不仅在早期发育过程中，而且在成年心脏中面临着各种压力，例如肥大，缺血，缺氧和慢性运动。此外，最近在治疗性血管生成研究的指数呈指数增加，其中许多是矛盾的，这表明我们需要对控制冠状血管形成的因素和机制有认识的理解。但是，这些数据的现有汇编仍然仅限于关注冠状动脉脉管系统特定领域的书籍。因此，没有一项全面的工作将这些个人主题汇总在一起。作为一名科学家，对冠状动脉研究的许多领域进行了研究和书面评论，PI具有将这些主题融合到全面的专着所需的独特背景。该应用程序的总体目的是写一篇专着，该专着考虑了其胚胎血统的层次结构，其产后的成长，成年和衰老。 这项批判性综述将考虑其关于其1）正常发育的冠状动脉脉管系统，2）异常及其可能的潜在发育错误，3）适应压力（例如高血压，低氧和缺血），以及4）衰老。该专着将是及时的，因为新技术使得发现了冠状动脉血管组装和生长的分子机制以及成人发生的适应和改变。除了利用现有文献外，还将合并来自人类胚胎的档案数据和实验动物模型的数据。该书将探索并进行严格分析文献，并将从实验动物与人类状况相关联。图像将包含在书中，扩展版本将在线。通过整合这些领域，临床医生和基础科学家可能会获得对冠状动脉血管生物学不同领域之间相互关系的重要见解。该专着的目的是至少三个组。首先，主要的目标受众由所有科学家，博士后研究员和研究生组成，这些研究生位于冠状动脉血管生物学领域。对于这一受众来说，专着既应该是扩大对血管生物学领域多样性的理解的关键参考，也应该是来源。第二个目标群是由血管生物学家组成的，其主要的兴趣是一般而言的血管发育机制，以及那些对心脏以外的器官血管化感兴趣的人。第三个针对性的群体是临床医生，他们应该认为该专着是有益的参考来源和概述。