Coronary Vessel Development, Adaptation and Therapeutic Interventions

冠状动脉的发育、适应和治疗干预

• 批准号: 7763992
• 负责人: ROBERT J TOMANEK
• 金额: $ 5万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2012-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7763992
• 关键词: Address; Adult; Affect; Aging; Aging-Related Process; Animal Model; Animals; Archives; Area; Basic Science; Biology; Blood Vessels; Blood capillaries; Blood flow; Books; Brain Hypoxia-Ischemia; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cartoons; Chronic; Clinic; Collection; Community Healthcare; Conflict (Psychology); Contracts; Coronary; Coronary Arteriosclerosis; Coronary Vessels; Data; Development; Disease; Embryo; Exercise; Experimental Animal Model; Goals; Growth; Health; Heart; Human; Hypertension; Hypertrophy; Image; Individual; Institutes; Laboratories; Link; Literature; Medicine; Metabolism; Microscopic; Molecular; Monograph; Morbidity - disease rate; Mus; Museums; Myocardial Ischemia; Myocardium; Organ; Oryctolagus cuniculus; Outcome; Oxygen; Paper; Pathology; Postdoctoral Fellow; Publications; Publishing; Rattus; Research; Scientist; Slide; Source; Stress; Therapeutic Intervention; Trees; United States; United States National Institutes of Health; Vascularization; Work; Writing; arm; capillary; coronary perfusion; density; graduate student; human data; insight; interest; mortality; new technology; postnatal; prevent; response; senescence; sound; therapeutic angiogenesis

DESCRIPTION (provided by applicant): The fact that ischemic heart disease is the leading cause of morbidity and mortality in the industrial world highlights the importance of the coronary vasculature. This proposal considers the importance of coronary vessel growth as essential, not only during early development, but also in the adult heart faced with various stresses, e.g. hypertrophy, ischemia, hypoxia and chronic exercise. Moreover, the recent exponential increase in studies on therapeutic angiogenesis, many of which are conflicting, suggests that we need to develop a sound understanding of the factors and mechanisms that govern coronary vessel formation. However, existing compilations of these data remain limited to books focusing on specific areas of the coronary vasculature. Thus, there is no single comprehensive work that brings these individual topics together. As a scientist who has conducted research and written reviews addressing many of the areas of coronary vessel research, the PI has the unique background necessary to bring these topics together into a comprehensive monograph. The overall goal of this application is to write a monograph that considers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood and senescence. This critical review will consider the coronary vasculature with regard to its 1) normal development, 2) anomalies and their possible underlying developmental errors, 3) adaptations to stress (e.g. hypertension, hypoxia and ischemia), and 4) aging. The monograph will be timely because novel technologies have enabled the discovery of molecular mechanisms underlying the assembly and growth of the coronary vasculature and adaptations and alterations that occur in the adult. In addition to utilizing the existing literature, data from archives on human embryos and on models of experimental animals will be incorporated. The book will explore and critically analyze the literature and relate data from experimental animals to the human condition. Images will be included in the book and an expanded version will be on-line. By integrating these areas, clinicians and basic scientists may gain important insights into the interrelationships between different areas of coronary vascular biology. The monograph is intended for at least three groups. First, a major target audience is comprised of all scientists, postdoctoral fellows and graduate students who are in any of the areas of coronary vascular biology. For this audience, the monograph should serve as both a key reference and a source for broadening their understanding of the diversity of the vascular biology field. A second targeted group consists of vascular biologists whose primary interest is in mechanisms of vascular development, in general, and those individuals whose interest is in the vascularization of organs other than the heart. The third targeted group is clinicians who should find the monograph to be a beneficial reference source and overview.

描述（由申请人提供）： 缺血性心脏病是工业世界发病率和死亡率的主要原因，这一事实突出了冠状动脉血管的重要性。该提议认为冠状血管生长的重要性是必不可少的，不仅在早期发育期间，而且在面临各种压力的成人心脏中，例如肥大、缺血、缺氧和慢性运动。此外，最近在治疗性血管生成的研究，其中许多是相互矛盾的指数增加，这表明我们需要制定一个合理的理解的因素和机制，管理冠状动脉血管形成。然而，这些数据的现有汇编仍然局限于专注于冠状动脉血管系统的特定区域的书籍。因此，没有一个综合性的工作，把这些个别的主题在一起。作为一名科学家，他已经进行了研究并撰写了涉及冠状动脉血管研究许多领域的评论，PI具有将这些主题整合到一本综合专著中所需的独特背景。本申请的总体目标是编写一本专著，考虑从胚胎起源到出生后生长、成年和衰老的冠状动脉血管系统的层次结构。 该批判性综述将考虑冠状动脉血管系统的以下方面：1）正常发育，2）异常及其可能的潜在发育错误，3）对应激的适应（例如高血压、缺氧和缺血），以及4）衰老。这本专著将是及时的，因为新的技术已经使发现的分子机制的组装和冠状动脉血管的生长和适应和改变发生在成人。除了利用现有文献外，还将纳入人类胚胎和实验动物模型档案中的数据。这本书将探索和批判性地分析文献，并将实验动物的数据与人类状况联系起来。图像将被列入这本书，并将在网上扩大版本。通过整合这些领域，临床医生和基础科学家可能会获得重要的见解冠状动脉血管生物学的不同领域之间的相互关系。各论至少适用于三个群体。首先，主要的目标受众是由冠状动脉血管生物学领域的所有科学家、博士后研究员和研究生组成。对于这些读者来说，专著应该作为一个重要的参考和来源，以扩大他们对血管生物学领域多样性的理解。第二个目标群体包括血管生物学家，他们的主要兴趣是血管发育的机制，一般来说，和那些个人的兴趣是在血管化的器官，而不是心脏。第三个目标群体是临床医生，他们应该发现专著是一个有益的参考来源和概述。