Coronary Vessel Development, Adaptation and Therapeutic Interventions

冠状动脉的发育、适应和治疗干预

• 批准号: 7763992
• 负责人: ROBERT J TOMANEK
• 金额: $ 5万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2012-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7763992
• 关键词: Address; Adult; Affect; Aging; Aging-Related Process; Animal Model; Animals; Archives; Area; Basic Science; Biology; Blood Vessels; Blood capillaries; Blood flow; Books; Brain Hypoxia-Ischemia; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cartoons; Chronic; Clinic; Collection; Community Healthcare; Conflict (Psychology); Contracts; Coronary; Coronary Arteriosclerosis; Coronary Vessels; Data; Development; Disease; Embryo; Exercise; Experimental Animal Model; Goals; Growth; Health; Heart; Human; Hypertension; Hypertrophy; Image; Individual; Institutes; Laboratories; Link; Literature; Medicine; Metabolism; Microscopic; Molecular; Monograph; Morbidity - disease rate; Mus; Museums; Myocardial Ischemia; Myocardium; Organ; Oryctolagus cuniculus; Outcome; Oxygen; Paper; Pathology; Postdoctoral Fellow; Publications; Publishing; Rattus; Research; Scientist; Slide; Source; Stress; Therapeutic Intervention; Trees; United States; United States National Institutes of Health; Vascularization; Work; Writing; arm; capillary; coronary perfusion; density; graduate student; human data; insight; interest; mortality; new technology; postnatal; prevent; response; senescence; sound; therapeutic angiogenesis

DESCRIPTION (provided by applicant): The fact that ischemic heart disease is the leading cause of morbidity and mortality in the industrial world highlights the importance of the coronary vasculature. This proposal considers the importance of coronary vessel growth as essential, not only during early development, but also in the adult heart faced with various stresses, e.g. hypertrophy, ischemia, hypoxia and chronic exercise. Moreover, the recent exponential increase in studies on therapeutic angiogenesis, many of which are conflicting, suggests that we need to develop a sound understanding of the factors and mechanisms that govern coronary vessel formation. However, existing compilations of these data remain limited to books focusing on specific areas of the coronary vasculature. Thus, there is no single comprehensive work that brings these individual topics together. As a scientist who has conducted research and written reviews addressing many of the areas of coronary vessel research, the PI has the unique background necessary to bring these topics together into a comprehensive monograph. The overall goal of this application is to write a monograph that considers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood and senescence. This critical review will consider the coronary vasculature with regard to its 1) normal development, 2) anomalies and their possible underlying developmental errors, 3) adaptations to stress (e.g. hypertension, hypoxia and ischemia), and 4) aging. The monograph will be timely because novel technologies have enabled the discovery of molecular mechanisms underlying the assembly and growth of the coronary vasculature and adaptations and alterations that occur in the adult. In addition to utilizing the existing literature, data from archives on human embryos and on models of experimental animals will be incorporated. The book will explore and critically analyze the literature and relate data from experimental animals to the human condition. Images will be included in the book and an expanded version will be on-line. By integrating these areas, clinicians and basic scientists may gain important insights into the interrelationships between different areas of coronary vascular biology. The monograph is intended for at least three groups. First, a major target audience is comprised of all scientists, postdoctoral fellows and graduate students who are in any of the areas of coronary vascular biology. For this audience, the monograph should serve as both a key reference and a source for broadening their understanding of the diversity of the vascular biology field. A second targeted group consists of vascular biologists whose primary interest is in mechanisms of vascular development, in general, and those individuals whose interest is in the vascularization of organs other than the heart. The third targeted group is clinicians who should find the monograph to be a beneficial reference source and overview.

描述(由申请人提供)： 在工业世界，缺血性心脏病是发病率和死亡率的主要原因，这一事实突显了冠状动脉血管系统的重要性。这一建议认为冠状动脉血管生长的重要性是必不可少的，不仅在早期发育期间，而且在面临各种应激，如肥厚、缺血、缺氧和慢性运动的成人心脏中也是如此。此外，最近关于治疗性血管生成的研究呈指数级增长，其中许多研究是相互矛盾的，这表明我们需要对控制冠状动脉血管形成的因素和机制有一个良好的理解。然而，现有的这些数据的汇编仍然局限于专注于冠状动脉血管系统特定区域的书籍。因此，没有一项全面的工作可以将这些单独的主题结合在一起。作为一名对冠状动脉研究的许多领域进行过研究和书面审查的科学家，PI具有将这些主题结合在一起形成一本全面专著所必需的独特背景。这个应用的总体目标是写一本专著，研究冠状动脉血管从胚胎起源到出生后生长、成年和衰老的层次结构。 本文将从1)正常发育、2)异常及其可能的潜在发育错误、3)对应激(如高血压、缺氧和缺血)的适应以及4)衰老等方面对冠状动脉血管系统进行综述。这本专著将是及时的，因为新技术使人们能够发现冠状血管组装和生长的分子机制，以及成年人发生的适应和变化。除了利用现有的文献外，还将纳入来自人类胚胎和实验动物模型的档案数据。这本书将探索和批判性地分析文献，并将实验动物的数据与人类状况联系起来。图像将包括在书中，扩展版本将在网上。通过整合这些领域，临床医生和基础科学家可能会对冠状动脉血管生物学不同领域之间的相互关系获得重要的见解。这本专著旨在至少面向三个群体。首先，主要的目标受众是冠脉血管生物学领域的所有科学家、博士后研究员和研究生。对于这些读者来说，这本专著应该作为一个关键的参考和来源，以扩大他们对血管生物学领域的多样性的理解。第二个目标群体由血管生物学家和那些对心脏以外器官的血管形成感兴趣的个人组成，他们的主要兴趣通常是血管发育的机制。第三个目标群体是临床医生，他们应该发现这本专著是一个有益的参考来源和概述。