The characterization of neuropeptides in the Planarian Schmidtea mediterranea

地中海涡虫中神经肽的表征

基本信息

项目摘要

DESCRIPTION (provided by applicant): Humans possess limited potential for regenerating lost or severely damaged tissue. As a result, many important human diseases are the direct result of irreversible tissue damage. While most human tissues do not regenerate, many animals are capable of replacing missing or damaged tissues. Elucidating the molecular mechanisms that regulate animal regeneration may lead to novel treatment strategies for people living with degenerative diseases. The nervous system has been widely recognized as an important regulator of regeneration in a variety of animals, but few studies have identified the specific neural signals that influence this process. Neuropeptides are secreted peptide hormones and represent the most diverse class of signaling molecules in metazoans. Previous studies of planarians have suggested that neuropeptides may influence regeneration, yet little is known about the diversity and types of neuropeptides that are present in flatworms. To test the hypothesis that neuropeptides influence regeneration, bioinformatic and biochemical approaches will be used to identify neuropeptide prohormone genes in the experimentally tractable planarian Schmidtea mediterranea. The expression patterns of these genes will be determined by whole-mount in situ hybridization and the role of these genes in the regulation of stem cells and regeneration will be determined by RNA interference. These studies will be an important test of the hypothesis that neuropeptides are important for regeneration and will provide essential groundwork for future studies into the role of peptide hormones in animal biology. Humans do not possess robust mechanisms to regenerate missing or damaged tissues and organs. The planarian Schmidtea mediterranea can regenerate every tissue in its body including its intestine, reproductive organs and brain. These studies aim to identify molecules important for the regeneration of S. mediterranea tissues.
描述(由申请人提供):人类再生丢失或严重受损组织的潜力有限。因此,许多重要的人类疾病是不可逆组织损伤的直接结果。虽然大多数人体组织不能再生,但许多动物能够替换缺失或受损的组织。阐明调节动物再生的分子机制可能会为患有退行性疾病的人带来新的治疗策略。神经系统被广泛认为是各种动物再生的重要调节器,但很少有研究确定了影响这一过程的特定神经信号。神经肽是一种分泌性肽激素,是后生动物中种类最多的信号分子。先前的研究表明,神经肽可能会影响再生,但对扁形虫中存在的神经肽的多样性和类型知之甚少。为了验证神经肽影响再生的假设,生物信息学和生物化学方法将被用来识别神经肽激素原基因在实验上听话的涡虫Schmidtea mediterranea。这些基因的表达模式将通过整体原位杂交来确定,并且这些基因在干细胞和再生的调节中的作用将通过RNA干扰来确定。这些研究将是对神经肽对再生很重要这一假设的重要检验,并将为未来研究肽激素在动物生物学中的作用提供必要的基础。人类没有强大的机制来再生缺失或受损的组织和器官。扁涡虫Schmidtea mediterranea可以再生身体的每一个组织,包括它的肠道,生殖器官和大脑。这些研究旨在鉴定对S.地中海组织。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Adult somatic stem cells in the human parasite Schistosoma mansoni.
  • DOI:
    10.1038/nature11924
  • 发表时间:
    2013-02-28
  • 期刊:
  • 影响因子:
    64.8
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James J Collins其他文献

Comparative Analysis of Cas9 Activators Across Multiple Species
多个物种 Cas9 激活剂的比较分析
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Alejandro Chavez;Marcelle Tuttle;Benjamin W Pruitt;Ben Ewen;Raj;Chari;Dmitry Ter;Sabina J. Haque;Ryan J. Cecchi;Emma J K Kowal;Joanna Buchthal;B. Housden;N. Perrimon;James J Collins;George Church
  • 通讯作者:
    George Church
Insulating gene circuits from context by RNA processing
通过 RNA 加工使基因回路与环境绝缘
  • DOI:
    10.1038/nbt.2411
  • 发表时间:
    2012-11-08
  • 期刊:
  • 影响因子:
    41.700
  • 作者:
    Caleb J Bashor;James J Collins
  • 通讯作者:
    James J Collins
RNA synthetic biology
RNA 合成生物学
  • DOI:
    10.1038/nbt1208
  • 发表时间:
    2006-05-05
  • 期刊:
  • 影响因子:
    41.700
  • 作者:
    Farren J Isaacs;Daniel J Dwyer;James J Collins
  • 通讯作者:
    James J Collins
Machine learning for synthetic gene circuit engineering
用于合成基因电路工程的机器学习
  • DOI:
    10.1016/j.copbio.2025.103263
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    7.000
  • 作者:
    Sebastian Palacios;James J Collins;Domitilla Del Vecchio
  • 通讯作者:
    Domitilla Del Vecchio

James J Collins的其他文献

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{{ truncateString('James J Collins', 18)}}的其他基金

Drug Target Discovery, Validation, and Prioritization for Schistosomiasis
血吸虫病药物靶标的发现、验证和优先排序
  • 批准号:
    10584296
  • 财政年份:
    2022
  • 资助金额:
    $ 5.13万
  • 项目类别:
Characterizing sexual development of the human parasite Schistosoma mansoni
人类寄生虫曼氏血吸虫的性发育特征
  • 批准号:
    10207379
  • 财政年份:
    2020
  • 资助金额:
    $ 5.13万
  • 项目类别:
Characterizing sexual development of the human parasite Schistosoma mansoni
人类寄生虫曼氏血吸虫的性发育特征
  • 批准号:
    10441417
  • 财政年份:
    2020
  • 资助金额:
    $ 5.13万
  • 项目类别:
Characterizing sexual development of the human parasite Schistosoma mansoni
人类寄生虫曼氏血吸虫的性发育特征
  • 批准号:
    10652328
  • 财政年份:
    2020
  • 资助金额:
    $ 5.13万
  • 项目类别:
The Biology of Stem Cells in the Human Parasite Schistosoma Mansoni
人类寄生虫曼氏血吸虫干细胞的生物学
  • 批准号:
    9207424
  • 财政年份:
    2016
  • 资助金额:
    $ 5.13万
  • 项目类别:
The Biology of Stem Cells in the Human Parasite Schistosoma Mansoni
人类寄生虫曼氏血吸虫干细胞的生物学
  • 批准号:
    10210085
  • 财政年份:
    2016
  • 资助金额:
    $ 5.13万
  • 项目类别:
The Biology of Stem Cells in the Human Parasite Schistosoma Mansoni
人类寄生虫曼氏血吸虫干细胞的生物学
  • 批准号:
    10544522
  • 财政年份:
    2016
  • 资助金额:
    $ 5.13万
  • 项目类别:
The Biology of Stem Cells in the Human Parasite Schistosoma Mansoni
人类寄生虫曼氏血吸虫干细胞的生物学
  • 批准号:
    9121333
  • 财政年份:
    2016
  • 资助金额:
    $ 5.13万
  • 项目类别:
The characterization of neuropeptides in the Planarian Schmidtea mediterranea
地中海涡虫中神经肽的表征
  • 批准号:
    7750680
  • 财政年份:
    2009
  • 资助金额:
    $ 5.13万
  • 项目类别:

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greenwashing behavior in China:Basedon an integrated view of reconfiguration of environmental authority and decoupling logic
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海藻、羊栖菜 (Sargassum fusiforme) 和赤木 (Sargassum horneri) 中砷的生化和烹饪行为
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