Neurobiological Underpinnings of Cognitive Deficits in Neurodevelopmental Disorde

描述(由申请者提供)：本申请是NIMH K23指导下的以患者为导向的研究职业发展奖。这项奖励将提供完成申请书中概述的拟议职业发展和研究活动所需的资源。简而言之，申请者建议获得必要的专业知识，以确立自己作为独立调查者的地位，探索儿童行为和神经发育障碍(如ADHD)的发展神经生物学。申请者将与她的导师团队合作，以实现以下三个培训目标：培训目标1：获得在发展框架内进行ADHD认知功能研究的知识和技能。培训目标2：发展必要的技能，使用功能磁共振成像方法实施研究，以检查与ADHD认知过程相关的皮质活动的变化。培训目标3：发展将功能磁共振成像技术与药物操作(即胆碱能药物挑战)相结合的技能，以检查与胆碱能系统操作相关的认知功能变化相关的大脑激活模式的变化。完成这项CDA后，申请者将拥有必要的技能、专业知识和初步数据，以确保获得资金(即NIH R01)，以开发她的研究计划，探索ADHD等认知障碍的胆碱能机制，这些障碍传统上是使用其他神经化学模型进行研究的。公共卫生相关性：这一新的研究路线将提供对ADHD神经生物学的更广泛了解，将进一步了解ADHD认知过程的发展轨迹，并可能指导ADHD新的药物治疗方法的开发。此外，从这项研究中获得的知识可能有助于理解青少年和成人ADHD患者的高吸烟率。

DESCRIPTION (provided by applicant): This application is for a NIMH K23 Mentored Patient Oriented Research Career Development Award. This award would provide the resources necessary to complete the proposed Career Development and Research Activities as outlined in the application. Briefly, the applicant proposes to gain the expertise necessary to establish herself as an independent investigator exploring the developmental neurobiology of child behavior and neurodevelopmental disorders such as ADHD. The applicant will work with her team of mentors to achieve the following three training goals: Training Goal 1: Acquire the knowledge and skills to conduct studies of cognitive function in ADHD within a developmental framework. Training Goal 2: Develop the necessary skills to implement studies using fMRI methodologies to examine changes in cortical activity associated with cognitive processes in ADHD. Training Goal 3: Develop the skills to combine the techniques of fMRI and pharmacological manipulations (i.e. cholinergic drug challenge) to examine the changes in patterns of brain activation related to changes in cognitive function associated with manipulations of the cholinergic system. Upon the completion of this CDA, the applicant will have the necessary skills, expertise, and preliminary data to secure funding (i.e. NIH R01) to develop her research program exploring cholinergic mechanisms of cognitive dysfunction in disorders such as ADHD, which have traditionally been studied using other neurochemical models. PUBLIC HEALTH RELEVANCE: This novel line of research will provide a broader understanding of the neurobiology of ADHD, will further our understanding of the developmental trajectory of cognitive process in ADHD, and may guide the development of new pharmacological treatments for ADHD. In addition, the knowledge gained from this study may contribute to understanding the high rates of smoking in adolescents and adults with ADHD.