Socioeconomic Status and Post-Injury Quality of Life and Functional Ability

描述（由申请人提供）：该K23奖将允许候选人获得必要的培训和技能，以开发和领导以患者为导向的研究项目，研究损伤后的生活质量和功能结果。职业发展计划的目标是让候选人获得核心知识，在研究方法、数据管理和解释方面获得进一步的专业知识，并加强他的科学写作和学术领导能力。为了实现职业发展目标，候选人将拥有一个跨学科的导师团队，将有深入的教学经验，将进行一个指导的研究项目，并将在他感兴趣的领域制定未来的研究方案。候选人的指导研究计划将利用田纳西大学健康科学中心的资源和候选人导师（Donna Hathaway博士、Andrew Bush博士和Timothy Fabian医学博士）的指导来实现项目的具体目标。具体目的是：(1)确定损伤前社会经济地位与中重度损伤后功能能力的关系；(2)探讨损伤前社会经济状况与中重度损伤后生活质量的关系。为了实现这些目标，250名中度至重度受伤的人将被送入田纳西州孟菲斯市半径150英里的唯一一级创伤中心，进行为期一年的随访。有关参与者个人水平的社会经济地位和损伤前的生活质量和功能能力的详细信息将尽可能接近入院时间。将使用地理编码确定参与者居住的具体人口普查区组。从这些信息中，将根据人口普查数据确定具体的社区一级社会经济指标。在随访期间，将确定患者的功能能力和生活质量。利用层次线性模型确定损伤前个体和社区社会经济地位与损伤后功能能力和生活质量之间的关系。因为每年有超过2800万美国人受伤，他们来自各行各业，了解社会经济地位如何影响受伤后的恢复是至关重要的。一旦了解了这种关系，就可以设计干预措施，以确保各行各业的受伤人员在受伤后能够达到最高水平的功能能力和生活质量。

DESCRIPTION (provided by applicant): This K23 award will allow the candidate to obtain the training and skills necessary to develop and lead patient-oriented research projects in the field of quality of life and functional outcomes after injury. The aims of the career development plan are for the candidate to acquire core knowledge, to gain further expertise in research methodology, data management and interpretation, and to strengthen his scientific writing, and academic leadership skills. To achieve the career development aims, the candidate will have an interdisciplinary mentor team, will have an in-depth didactic experience, will carry out a mentored research project and will develop future research protocols in his area of interest. The candidate's mentored research plan will utilize the resources of the University of Tennessee Health Science Center and guidance of the candidate's mentors (Donna Hathaway, PhD, Andrew Bush, PhD, and Timothy Fabian, MD) to achieve the specific aims of the project. The specific aims are: (1) To determine the relationship between pre-injury socioeconomic status and functional ability following moderate to severe injury; (2) To investigate the association between pre-injury socioeconomic status and quality of life following moderate to severe injury. To address these aims 250 moderately to severely injured persons admitted to the only Level I Trauma Center for a 150-mile radius to Memphis, Tennessee will be followed for one year. Detailed information regarding participants' individual level socioeconomic status and pre-injury quality of life and functional ability will be obtained as close to the time of admission as possible. The specific census tract group in which the participant lives will be determined using geocoding. From this information specific neighborhood level socioeconomic indicators will be determined from Census Data. Over the follow-up period, determinations of functional ability and quality of life will be made. The relationship between pre-injury socioeconomic status on the individual and neighborhood level and post-injury functional ability and quality of life will be determined using hierarchical linear modeling. Because injury touches over 28 million Americans a year from all walks of life, understanding how socioeconomic status influences recovery after injury is critical. Once this relationship is understood, interventions can be designed to ensure that injured people from all walks of life will achieve the highest levels of functional ability and quality of life possible after injury.