Kidney Disease in HIV-Hepatitis C Virus Co-Infection

描述（由申请人提供）： 随着抗逆转录病毒疗法的广泛采用，艾滋病毒已成为一种慢性疾病，与艾滋病毒有关的肾脏疾病已成为发病和死亡的重要原因。HIV感染和抗逆转录病毒治疗都与肾脏疾病有关。研究表明，HIV-丙型肝炎病毒合并感染的患者中HIV相关肾脏疾病的风险增加，但研究并未关注这些患者中肾脏疾病的流行病学。全世界估计有4000万人感染艾滋病毒，400万至500万人同时感染艾滋病毒和丙型肝炎。艾滋病毒-丙型肝炎合并感染的最高流行率发生在肾脏疾病风险增加的少数群体中。该提案旨在调查HIV-丙型肝炎合并感染患者肾脏疾病的流行病学，并确定与风险增加相关的宿主和病毒因素。风险因素的识别将识别可能受益于早期发现和治疗肾脏疾病的增强筛查的患者。该申请的主要目的是支持候选人作为HIV相关肾脏疾病领域的独立临床和翻译研究者的发展。 这项建议的具体目标是： (1)比较HIV-丙型肝炎合并感染患者与HIV或丙型肝炎病毒单独感染患者肾脏疾病的流行病学。 (2)确定与HIV-丙型肝炎合并感染患者肾脏疾病相关的宿主因素。 (3)确定与HIV-丙型肝炎合并感染患者肾脏疾病相关的病毒因素。 相关性：艾滋病毒影响着全世界4000多万人，肾脏疾病是接受艾滋病毒治疗的患者的重要并发症。同时感染HIV和丙型肝炎病毒的少数患者可能患肾脏疾病的风险特别高。这项研究将有助于识别可能有肾脏疾病风险的艾滋病毒感染者，以便在肾衰竭和其他严重并发症发生之前诊断和治疗肾脏疾病。

DESCRIPTION (provided by applicant): With the widespread introduction of antiretroviral therapy, HIV has become a chronic disease, and HIV- related kidney disease has emerged as an important cause of morbidity and mortality. Both HIV infection and antiretroviral therapy have been associated with kidney disease. Studies suggest that the risk of HIV-related kidney disease is increased in patients with HIV-Hepatitis C virus co-infection, but studies have not focused on the epidemiology of kidney disease in these patients. Worldwide, an estimated 40 million people are infected with HIV, and 4-5 million people are co-infected with HIV and Hepatitis C. The highest prevalence of HIV-Hepatitis C co-infection occurs in minority populations at increased risk for kidney disease. This proposal aims to investigate the epidemiology of kidney disease in patients with HIV-Hepatitis C co-infection, and to identify host and viral factors associated with increased risk. The identification of risk factors will identify patients who may benefit from enhanced screening for early detection and treatment of kidney disease. The primary objective of this application is to support the candidate's development as an independent clinical and translational investigator in the field of HIV-related kidney disease. The specific aims of this proposal are: (1) To compare the epidemiology of kidney disease in patients with HIV-Hepatitis C co-infection to that in patients with either HIV or Hepatitis C virus alone. (2) To identify host factors associated with kidney disease in patients with HIV-Hepatitis C co-infection. (3) To identify viral factors associated with kidney disease in patients with HIV-Hepatitis C co-infection. Relevance: HIV affects more than 40 million people worldwide, and kidney disease is an important complication in patients being treated for HIV. Minority patients with both HIV and Hepatitis C virus infection may be at particularly high risk for kidney disease. This study will help to identify HIV-infected patients who may be at risk for kidney disease, in order to diagnose and treat kidney disease before the development of kidney failure and other serious complications.