临床核心（MSSM）-猫眼课题宝

临床核心（MSSM）

批准号：

9768914

负责人：

CHRISTINA M WYATT

金额：

$18.87万

依托单位：

BAYLOR COLLEGE OF MEDICINE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/9768914

关键词：

AIDS-Associated Nephropathy Acetylation African American Archives Bioinformatics Biological Blood specimen Cell Line Chronic Chronic Kidney Failure Clinical Clinical Data Clinical Research Consequences of HIV Data Development Diabetic mouse End stage renal failure Enrollment Ensure Epidemiology Epithelial Cells Gene Expression HIV HIV Infections Health Histologic Histology Histopathology Human Immune response In Vitro Individual Inflammatory Injury Kidney Kidney Diseases Laboratories Laboratory Finding Life Cycle Stages Link Logistics Mitochondria Natural History Nephrology Participant Pathogenesis Pathway interactions Patients Pattern Process Protocols documentation Research Research Design Research Personnel Research Support Resources Risk Role SIRT1 gene Specimen Standardization Tissues Transgenic Mice Transgenic Organisms Tubular formation Urine Viral Viral reservoir Work antiretroviral therapy cell immortalization data warehouse disorder risk gut microbiota high risk host microbiome human subject immortalized cell inflammatory marker kidney biopsy mouse model nephrotoxicity programs prospective recruit senescence stool sample synergism transcription factor

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Project Summary (Core C) The objective of the Clinical Core (Core C) is to provide biologic specimens and corresponding clinical and laboratory data from well-characterized patients with HIV infection and kidney disease and from relevant controls to support the work proposed in this Program Project. The Clinical Core will provide kidney tissue, urine, blood, and stool specimens to support research into the long-term consequences of chronic HIV infection in the kidney, including the role of HIV infection in promoting kidney disease and the potential for the kidney to serve as a reservoir for the virus.

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