临床核心（MSSM）-猫眼课题宝

临床核心（MSSM）

批准号：

9588832

负责人：

CHRISTINA M WYATT

金额：

$18.04万

依托单位：

BAYLOR COLLEGE OF MEDICINE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/9588832

关键词：

AIDS-Associated Nephropathy Acetylation African American Archives Bioinformatics Biopsy Blood specimen Cell Line Chronic Chronic Kidney Failure Clinical Clinical Data Clinical Research Consequences of HIV Data Development Diabetic mouse End stage renal failure Enrollment Ensure Epidemiology Epithelial Cells Gene Expression HIV HIV Infections Health Histologic Histology Histopathology Human Immune response In Vitro Individual Inflammatory Injury Kidney Kidney Diseases Laboratories Laboratory Finding Life Cycle Stages Link Logistics Mitochondria Natural History Nephrology Participant Pathogenesis Pathway interactions Patients Pattern Process Protocols documentation Research Research Design Research Personnel Research Support Resources Risk Role SIRT1 gene Specimen Standardization Tissues Transgenic Mice Transgenic Organisms Tubular formation Urine Viral Viral reservoir Work antiretroviral therapy cell immortalization data warehouse disorder risk gut microbiota high risk host microbiome human subject immortalized cell inflammatory marker mouse model nephrotoxicity programs prospective recruit senescence stool sample synergism transcription factor

项目摘要

项目成果

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中文摘要

翻译

项目摘要(核心C) 临床核心(核心C)的目标是提供生物标本和相应的临床和来自具有良好特征的HIV感染和肾脏疾病患者的实验室数据以及来自相关的用于支持本计划项目中提议的工作的控制。临床核心将提供肾脏组织，尿液、血液和粪便样本，以支持对慢性艾滋病毒长期后果的研究肾脏感染，包括艾滋病毒感染在促进肾脏疾病中的作用以及肾脏作为病毒的储存库。

英文摘要

Project Summary (Core C) The objective of the Clinical Core (Core C) is to provide biologic specimens and corresponding clinical and laboratory data from well-characterized patients with HIV infection and kidney disease and from relevant controls to support the work proposed in this Program Project. The Clinical Core will provide kidney tissue, urine, blood, and stool specimens to support research into the long-term consequences of chronic HIV infection in the kidney, including the role of HIV infection in promoting kidney disease and the potential for the kidney to serve as a reservoir for the virus.

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