Support for the Rose F. Kennedy IDD Research Center

描述(由申请人提供)：罗斯·F·肯尼迪智力和发育障碍研究中心(RFK-IDDRC)的首要目标是通过研究和临床推广改善智力和发育障碍儿童的生活。作为NICHD的旗舰IDDRC之一，40年来在基础研究和临床护理方面的杰出历史，加上爱因斯坦最近重要的教员招聘和设施发展，共同播下了肯尼迪中心IDD计划复兴的种子。对这一进程至关重要的是一个新的肯尼迪中心领导团队，该团队提供合作和协作的愿景，使科学家和临床医生相互交织在一起，朝着将简单系统中的研究转化为与患者健康直接相关的临床洞察和治疗这一共同目标而努力。已经确定了四个研究主题，这些主题既体现了爱因斯坦的基础科学优势，也体现了布朗克斯和周围人口固有的与缺碘相关的关键临床问题，以及支持这些领域研究进展所必需的关键科学核心。研究主题集中在自闭症谱系障碍、神经发生和癫痫障碍的重叠和非常重要的领域， 大脑发育、耳聋和沟通障碍的营养和环境决定因素。六个科学核心旨在为人类和动物表型鉴定、神经元和全脑成像、细胞和组织操作以及基因分析提供手段，每个核心都具有战略意义，以提供试验台研究和患者护理方面的进步。这项工作的合作伙伴包括爱因斯坦神经科学和遗传学的强大研究引擎和其他关键学术部门，以及肯尼迪中心的临床附属机构-儿童评估和康复中心(CERC)和蒙特菲奥里儿童医院(CHAM)。这些临床中心及其贡献的临床部门为该国最贫困的城市人口之一提供服务，那里的智力和发育障碍发生在经济贫困、服务不足的种族混杂的少数族裔人口中。这些非凡的研究和临床资源，再加上重新开发和鼓舞人心的领导力和计划，为罗斯·F·肯尼迪中心努力实现改善智力和发育障碍儿童生活的目标奠定了新时代的基础。 公共卫生相关性(见说明)：智力和发育障碍(IDD)是影响儿童健康的最重要类别之一，仅在美国就影响数十万人。这项提议的目的是建立一个IDD研究中心，即Rose F.Kennedy IDDRC，作为一种手段，促进神经科学和遗传学方面的尖端科学和翻译研究计划，以及专注于诊断和患者护理的专注、深入的临床工作。

DESCRIPTION (provided by applicant): The overarching goal of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK-IDDRC) is to improve the lives of children with intellectual and developmental disabilities through research and clinical outreach. Forty years of distinguished history in basic research and clinical care as one ofthe flagship IDDRCs of NICHD, coupled with important recent faculty recruitments and facility developments at Einstein have, in concert, sown the seeds of a rennaissance in the Kennedy Center IDD program. Critical to this process is a new Kennedy Center leadership team providing a vision of cooperation and collaboration whereby bench scientists and clinicians work intertwined toward the common goal of translating studies in simple systems to clinical insight and therapies with direct relevance to patient health. Four research themes embodying both the basic science strengths at Einstein and critical IDD-related clinical issues inherent in the Bronx and surrounding populations have been identified, as have key scientific cores essential for supporting research advances in these areas. Research themes are focused on the overlapping and ail-important areas of Autism Spectrum Disorders, Neurogenetic and Seizure Disorders, Nutritional and Environmental Determinants of Brain Development, and Deafness and Communication Disorders. Six scientific cores are designed to provide the means for both human and animal phenotyping, neuron and whole brain imaging, cell and tissue manipulation, and genetic analyses, with each centered strategically to provide advancements in bench research and patient care. Partners in this effort include the powerful research engines of Neuroscience and Genetics and other key academic departments at Einstein along with the Kennedy Center's clinical affiliates - the Children's Evaluation and Rehabiltiation Center (CERC) and the Children's Hospital At Montefiore (CHAM). These clinical centers and their contributing clinical departments serve one of the neediest urban populations in the country, where intellectual and developmental disabilities occur in economically deprived, and underserved racially-mixed minority populations. These remarkable research and clincial resources, coupled with a reinvorgorate and inspired leadership and program, provide the basis for a new era for the Rose F. Kennedy Center as it strives toward its goal of improving the lives of children with intellectual and developmental disabilities. PUBLIC HEALTH RELEVANCE (See Instructions): Intellectual and Developmental Disabilities (IDD) represent one of the most significant categories of health impact involving children, affecting hundreds of thousands of individuals in the US alone. The purpose of this proposal is to establish an IDD research center, the Rose F. Kennedy IDDRC, as a means to promote a program of cutting-edge scientific and translational research in neuroscience and genetics coupled with dedicated, indepth clinical efforts focused on diagnosis and patient care.