Support for the Rose F. Kennedy IDD Research Center

对 Rose F. Kennedy IDD 研究中心的支持

• 批准号: 8246586
• 负责人: Steven Upshaw Walkley
• 金额: $ 109.73万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8246586
• 关键词: Support; Rose; F.; Kennedy; IDD

DESCRIPTION (provided by applicant): The overarching goal of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK-IDDRC) is to improve the lives of children with intellectual and developmental disabilities through research and clinical outreach. Forty years of distinguished history in basic research and clinical care as one ofthe flagship IDDRCs of NICHD, coupled with important recent faculty recruitments and facility developments at Einstein have, in concert, sown the seeds of a rennaissance in the Kennedy Center IDD program. Critical to this process is a new Kennedy Center leadership team providing a vision of cooperation and collaboration whereby bench scientists and clinicians work intertwined toward the common goal of translating studies in simple systems to clinical insight and therapies with direct relevance to patient health. Four research themes embodying both the basic science strengths at Einstein and critical IDD-related clinical issues inherent in the Bronx and surrounding populations have been identified, as have key scientific cores essential for supporting research advances in these areas. Research themes are focused on the overlapping and ail-important areas of Autism Spectrum Disorders, Neurogenetic and Seizure Disorders, Nutritional and Environmental Determinants of Brain Development, and Deafness and Communication Disorders. Six scientific cores are designed to provide the means for both human and animal phenotyping, neuron and whole brain imaging, cell and tissue manipulation, and genetic analyses, with each centered strategically to provide advancements in bench research and patient care. Partners in this effort include the powerful research engines of Neuroscience and Genetics and other key academic departments at Einstein along with the Kennedy Center's clinical affiliates - the Children's Evaluation and Rehabiltiation Center (CERC) and the Children's Hospital At Montefiore (CHAM). These clinical centers and their contributing clinical departments serve one of the neediest urban populations in the country, where intellectual and developmental disabilities occur in economically deprived, and underserved racially-mixed minority populations. These remarkable research and clincial resources, coupled with a reinvorgorate and inspired leadership and program, provide the basis for a new era for the Rose F. Kennedy Center as it strives toward its goal of improving the lives of children with intellectual and developmental disabilities. PUBLIC HEALTH RELEVANCE (See Instructions): Intellectual and Developmental Disabilities (IDD) represent one of the most significant categories of health impact involving children, affecting hundreds of thousands of individuals in the US alone. The purpose of this proposal is to establish an IDD research center, the Rose F. Kennedy IDDRC, as a means to promote a program of cutting-edge scientific and translational research in neuroscience and genetics coupled with dedicated, indepth clinical efforts focused on diagnosis and patient care.

描述（由申请人提供）：罗斯·肯尼迪智力和发育障碍研究中心（RFK-IDDRC）的首要目标是通过研究和临床推广来改善智力和发育障碍儿童的生活。作为NICHD的旗舰iddrc之一，在基础研究和临床护理方面有着40年的杰出历史，加上爱因斯坦中心最近重要的教师招聘和设施发展，共同为肯尼迪中心IDD项目的复兴播下了种子。这一过程的关键是一个新的肯尼迪中心领导团队提供合作和协作的愿景，使实验室科学家和临床医生为将简单系统的研究转化为与患者健康直接相关的临床见解和治疗的共同目标而交织在一起。四个研究主题既体现了爱因斯坦的基础科学优势，也体现了布朗克斯和周边人群固有的关键缺乏症相关临床问题，同时也确定了支持这些领域研究进展的关键科学核心。研究主题集中在自闭症谱系障碍、神经遗传和癫痫性疾病、