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Support for the Rose F. Kennedy IDD Research Center

对 Rose F. Kennedy IDD 研究中心的支持

基本信息

批准号：
8507783
负责人：
Steven Upshaw Walkley
金额：
$ 107.09万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-26 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8507783
关键词：
Affect Animal Behavior Animals Area Autistic Disorder Award Basic Science Biomedical Research Brain Brain imaging Categories Cells Child Childhood Clinical Clinical Sciences Collaborations Communication Communication impairment Communities Country Coupled Development Diagnosis Disease Economically Deprived Population Educational workshop Elements Ensure Epilepsy Evaluation Faculty Family Fostering Funding Genetic Goals Health Human Individual Institutes Institution Instruction Intellectual functioning disability Leadership Mental Retardation Mental Retardation and Developmental Disabilities Research Centers Methods Minority Mission National Institute of Child Health and Human Development Neurons Neurosciences Neurosciences Research Nutritional Online Systems Other Genetics Patient Care Patients Pediatric Hospitals Phenotype Pilot Projects Population Prevention Process Recording of previous events Recruitment Activity Rehabilitation Centers Renaissance Research Research Personnel Research Support Resources Role Rosa Scientist Seeds Services Support Groups System Time Tissue Engineering Tissues Training Translating Translational Research Travel Universities Urban Population Vision Work autism spectrum disorder base cellular imaging clinical care clinical phenotype deafness design developmental disease expectation experience genetic analysis health disparity improved innovation insight intellectual and developmental disability lectures meetings molecular imaging neurogenetics neuroimaging operation outreach outreach program programs success

项目摘要

DESCRIPTION (provided by applicant): The overarching goal of the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK-IDDRC) is to improve the lives of children with intellectual and developmental disabilities through research and clinical outreach. Forty years of distinguished history in basic research and clinical care as one ofthe flagship IDDRCs of NICHD, coupled with important recent faculty recruitments and facility developments at Einstein have, in concert, sown the seeds of a rennaissance in the Kennedy Center IDD program. Critical to this process is a new Kennedy Center leadership team providing a vision of cooperation and collaboration whereby bench scientists and clinicians work intertwined toward the common goal of translating studies in simple systems to clinical insight and therapies with direct relevance to patient health. Four research themes embodying both the basic science strengths at Einstein and critical IDD-related clinical issues inherent in the Bronx and surrounding populations have been identified, as have key scientific cores essential for supporting research advances in these areas. Research themes are focused on the overlapping and ail-important areas of Autism Spectrum Disorders, Neurogenetic and Seizure Disorders, Nutritional and Environmental Determinants of Brain Development, and Deafness and Communication Disorders. Six scientific cores are designed to provide the means for both human and animal phenotyping, neuron and whole brain imaging, cell and tissue manipulation, and genetic analyses, with each centered strategically to provide advancements in bench research and patient care. Partners in this effort include the powerful research engines of Neuroscience and Genetics and other key academic departments at Einstein along with the Kennedy Center's clinical affiliates - the Children's Evaluation and Rehabiltiation Center (CERC) and the Children's Hospital At Montefiore (CHAM). These clinical centers and their contributing clinical departments serve one of the neediest urban populations in the country, where intellectual and developmental disabilities occur in economically deprived, and underserved racially-mixed minority populations. These remarkable research and clincial resources, coupled with a reinvorgorate and inspired leadership and program, provide the basis for a new era for the Rose F. Kennedy Center as it strives toward its goal of improving the lives of children with intellectual and developmental disabilities.

描述（由申请人提供）：玫瑰F的首要目标。肯尼迪智力和发育障碍研究中心（RFK-IDDRC）是通过研究和临床推广来改善智力和发育障碍儿童的生活。作为NICHD的旗舰IDDRCs之一，在基础研究和临床护理方面有着40年的杰出历史，加上爱因斯坦最近重要的教师招聘和设施发展，共同播下了肯尼迪中心IDD计划的种子。对这一过程至关重要的是新的肯尼迪中心领导团队提供了合作与协作的愿景，使实验室科学家和临床医生相互交织，共同目标是将简单系统中的研究转化为与患者健康直接相关的临床见解和治疗。四个研究主题体现了爱因斯坦的基础科学优势和布朗克斯及周边人群固有的关键IDD相关临床问题，已经确定了支持这些领域研究进展所必需的关键科学核心。研究主题集中在自闭症谱系障碍，神经遗传和癫痫发作障碍，脑发育的营养和环境决定因素，以及耳聋和沟通障碍。六个科学核心旨在为人类和动物的表型分析、神经元和全脑成像、细胞和组织操作以及遗传分析提供手段，每个核心都以战略为中心，以促进实验室研究和患者护理。这项工作的合作伙伴包括神经科学和遗传学的强大研究引擎和爱因斯坦沿着的其他关键学术部门以及肯尼迪中心的临床附属机构-儿童评估和鉴定中心（CERC）和蒙蒂菲奥里儿童医院（CHAM）。这些临床中心及其贡献的临床部门服务于该国最需要的城市人口之一，其中智力和发育障碍发生在经济贫困和服务不足的种族混合少数群体中。这些卓越的研究和临床资源，再加上一个reinvorgorate和鼓舞人心的领导和计划，提供了一个新时代的基础，为玫瑰F。肯尼迪中心，因为它努力实现其改善智力和发育障碍儿童的生活的目标。