EFFECT OF ADJUVANT CHEMO FOR EARLY BREAST CA ON BRAIN IMAGING AMP; COGNITION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 化疗相关的认知功能障碍，即所谓的“化疗障碍”，是一种广泛报道但尚未明确定义的化疗并发症。尽管人们对这种潜在的毒性表示了很大的关注，但对化疗可能导致的中枢神经系统的变化却知之甚少。这项建议旨在研究50名接受常用化疗方案辅助治疗的早期乳腺癌患者。除了专注于先前研究中发现的特定认知问题的认知测试外，该试验还将专注于磁共振成像(MRI)定义的神经解剖学和神经功能变化，包括检查记忆任务等认知操作期间大脑活动变化的功能磁共振(FMRI)，以及一种提供脑白质完整性的精细成像技术(扩散张量成像，DTI)。我们还将测试APOE基因是否可能与化疗后认知功能障碍的发展有关，APOE基因与衰老和痴呆的认知功能障碍有关。患者在化疗前、化疗后和一年后将进行认知功能测试、成像和采血。从该项目获得的信息将被用来确定这种并发症的风险和频率，并导致进一步的更大规模的试验，以探索干预措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chemotherapy-related cognitive dysfunction, so called "chemobrain" is a widely reported yet poorly defined complication of chemotherapy. Although much concern has been expressed about this potential toxicity, little is know about the central nervous system changes that may result from chemotherapy administration. This proposal is designed to study 50 women with early stage breast cancer receiving commonly used chemotherapy regimens used for adjuvant treatment. In addition to cognitive testing focusing on specific cognitive problems identified from prior studies, the trial will focus on neuroanatomical and neurofunctional changes defined by magnetic resonance imaging (MRI) including both functional MRI (fMRI) examining alterations in brain activity during cognitive operations such as memory tasks, and a technique that provides exquisite imaging of the white matter integrity of the brain (diffusion tensor imaging, DTI). We will also test whether the APOE genotype, which has been related to cognitive impairment in aging and dementia, may be associated with the development of cognitive dysfunction with chemotherapy. Patients will have cognitive function testing, imaging and blood collection prior to chemotherapy treatment, after chemotherapy treatment, and at one year. The information obtained from this project will be used to define the risk and frequency of this complication and lead to further larger trials that will explore interventions.