OUTCOMES OF ONCOLOGY THERAPY IN THE ELDERLY: FUNCTIONAL DECLINE

老年人肿瘤治疗的结果：功能衰退

• 批准号: 8166993
• 负责人: Kim Dittus
• 金额: $ 0.17万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166993
• 关键词: Adverse effects; Age; Blood; Cancer Patient; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Elderly; Fatigue; Funding; Future; Grant; Household; Impairment; Institution; Intention; Intervention; Knowledge; Leg; Lower Extremity; Malignant Neoplasms; Measures; Modeling; Muscle Fatigue; Outcome; Pain; Participant; Performance; Quality of life; Questionnaires; Research; Research Personnel; Resources; Safety; Shortness of Breath; Simulate; Sleep; Source; Surveys; Survivors; Symptoms; Testing; Time; United States National Institutes of Health; Ursidae Family; Vulnerable Populations; Walking; cancer therapy; cancer type; cost; functional decline; improved functioning; meetings; muscle strength; oncology; psychological distress

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Changes in cancer therapy over the past 20 years have created better options for treatment and improvements in survival. Older adults over age 65 are a large and growing proportion of cancer patients and survivors, yet the functional cost of therapy in this vulnerable population is largely unknown. Potential changes include decreased strength, loss of lean body mass, decreased ability to perform tasks needed to participate in daily activities. Function declines will depend on function at baseline, the type of cancer and the side effects of the cancer therapy. Studies show that cancer patients who receive cancer treatment bear the burden of side effects from both cancer and treatment. Maintaining function is important to older adult's quality of life. In the future it will be increasingly important to help older cancer patients stay as functional as possible. The study looks at functional change of elderly cancer patients. Approximately 52 cancer patients age 65 or older will be asked to participate. Cancer patients asked to participate will be receiving cancer therapy with the intention of providing a cure. Functional change will be assessed from the time of diagnosis, through therapy to the early post therapy time frame. A comprehensive model explaining reasons for function change is used as the framework for choosing variables to measure. Components of function that will be measured include a 6 minute walk test, lower extremity muscle strength, a Short Physical Performance Battery assessing function of legs and a test that simulates typical household activities. Surveys will be used to subjects own assessment of their activity and function. The four most common cancer-related side effects will be measured and include fatigue, sleep impairment, shortness of breath and pain. Some markers in the blood may be abnormal and be related to declines in function. They will also be measured. Differences in function over time will be determined and relationships between function, cancer-related side effects and quality of life will be assessed. The proposed project will document the degree of function decline, assess the relationship between function and cancer- related symptoms and evaluate relationships between function and quality of life. A small amount of psychological distress may be associated with completing the questionnaires. The test to measure function may cause muscle fatigue or strain. Participants will meet safety criteria before their function is measured. Knowledge gained will help us plan interventions around the time of cancer therapy to help older adults preserve or improve function.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去的20年里，癌症治疗的变化为治疗和提高存活率创造了更好的选择。65岁以上的老年人在癌症患者和幸存者中所占的比例很大，而且还在不断增长，但在这一脆弱的人群中，治疗的功能成本在很大程度上是未知的。潜在的变化包括力量下降，瘦体重下降，执行参与日常活动所需任务的能力下降。功能下降将取决于基线功能、癌症类型和癌症治疗的副作用。研究表明，接受癌症治疗的癌症患者承担着癌症和治疗的副作用。维持功能对老年人的生活质量很重要。在未来，帮助老年癌症患者尽可能保持功能将变得越来越重要。 这项研究着眼于老年癌症患者的功能变化。大约52名65岁或以上的癌症患者将被要求参加。被要求参与的癌症患者将接受癌症治疗，目的是提供治愈的打算。功能变化将从诊断时、治疗期间到治疗后早期进行评估。一个解释函数变化原因的综合模型被用作选择要衡量的变量的框架。将测量的功能组件包括6分钟步行测试、腿部肌肉力量、腿部短时体能电池评估功能以及模拟典型家庭活动的测试。调查将用于受试者自己对其活动和功能的评估。将测量与癌症有关的四种最常见的副作用，包括疲劳、睡眠障碍、呼吸急促和疼痛。血液中的一些标志物可能是异常的，可能与功能下降有关。他们也将被衡量。随着时间的推移，将确定功能的差异，并将评估功能、癌症相关副作用和生活质量之间的关系。 拟议的项目将记录功能下降的程度，评估功能与癌症相关症状之间的关系，并评估功能与生活质量之间的关系。少量的心理困扰可能与完成调查问卷有关。测试功能可能会导致肌肉疲劳或劳损。参与者在对其功能进行测量之前将满足安全标准。所获得的知识将帮助我们在癌症治疗期间计划干预措施，以帮助老年人保持或改善功能。