CANDIDA INVASION OF ENDOTHELIUM AND VIRULENCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是研究白色念珠菌与血管内皮细胞的相互作用。这些细胞形成血管的内层。这项研究的长期目标是了解白色念珠菌是如何入侵和破坏这些细胞的，以便开发出阻止这一过程的方法。这项工作很重要，因为即使在目前可用的治疗方法下，播散性念珠菌感染患者的死亡率也约为40%。在拟议的研究中，内皮细胞将从人脐带内的静脉中采集，并在组织培养中生长。脐带将在未感染的捐赠者正常阴道分娩后获得。不会收集有关母亲或婴儿的信息。脐带捐赠者的身份将不会被识别，脐带血也不会被收集。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research project is to study the interactions of the fungus, Candida albicans, with endothelial cells. These cells form the inner lining of the blood vessels. The long-range goal of this research is to understand how C. albicans invades and damages these cells so that methods to block this process can be developed. This work is important because the mortality of patients with a disseminated candidal infection is approximately 40%, even with currently available therapy. For the proposed studies, the endothelial cells will be harvested from the veins within human umbilical cords and grown in tissue culture. The umbilical cords will be obtained after normal vaginal births from uninfected donors. No information about the mother or baby will be collected. The donors of the cords will not be identified and the umbilical cord blood will not be collected.