MECHANISMS OF INCREASED ANDROGEN PRODUCTION AMONG PCOS WOMEN

多囊卵巢综合征女性雄激素分泌增加的机制

• 批准号: 8166881
• 负责人: R JEFFREY CHANG
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166881
• 关键词: Adrenal Glands; Androgens; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Human Chorionic Gonadotropin; Institution; Insulin; Output; Production; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Woman; granulosa cell; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1. Determine the effect of FSH-stimulated granulosa cells on androgen responses to hCG in PCOS women. 2. Determine the contribution of adrenal androgen production to total androgen output in women with PCOS. 3. Determine the role of insulin on basal and stimulated androgen production in women with PCOS.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 1. 确定FSH刺激的颗粒细胞对PCOS妇女雄激素对hCG反应的影响。 2. 确定PCOS妇女肾上腺雄激素产生对总雄激素输出的贡献。 3. 确定胰岛素对PCOS妇女基础和刺激雄激素产生的作用。