Natl Phys Coop to Preserve Fertility for Female Cancer Patients

国家物理合作社为女性癌症患者保留生育能力

• 批准号: 7928237
• 负责人: R JEFFREY CHANG
• 金额: $ 35.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-29 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7928237
• 关键词: Cancer Patient; Female; Fertility

Although malignancy remains a critical health concern, significant medical advances in cancer detection and treatment have improved the survival rates for patients. As patients live longer, the consequences of cancer management have assumed greater importance. Traditionally, cancer patients have been faced with great uncertainty and have had few choices for fertility preservation. However, recent scientific advances employing a three-dimensional scaffold system usingx alginate for the in vitro maturation of ovarian follicles reveals promising new technologies for clinical applications. The mission of the National Physicians Cooperative (NPC) Tissue Core is to collect and distribute human ovarian tissue containing follicles to the basic science components of the Oncofertility Consortium. By doing so, we will catalyze the translation of the basic science knowledge gained in project RO1C and the Biomaterial Core (P30A) to women with a cancer diagnosis. The NPC is comprised of five Core institutions and fifteen Allied centers across the country. The elements of this program include patient screening and selection, collection of clinical and laboratory data, standardization of operative techniques for oophorectomy, post-surgical handling of tissues, tracking and storage of ovarian specimens, and a process of tissue distribution to participating sites. Furthermore, the Core will work closely with the social science section (RO1D) to address the ethical, legal, economic, and social considerations that will emerge from the new discipline of Oncofertility. The primary goals of this proposal are (1) to collect adult human ovaries from women with cancer and distribute them for basic science research; (2) to educate providers, patients, and the community through the Allied centers about fertility options for women with cancer; and (3) to disseminate the technical knowledge of follicle maturation and cryopreservation to the Allied centers. The collective goal is to ultimately provide new options for fertility preservation. The NPC will provide the vehicle through which breakthroughs in basic reproductive physiology will be translated to clinical medicine and, ideally, overcome the infertility and subfertility faced by many women undergoing cancer treatment. Restoration of fertility and other ovarian functions would substantially improve the quality of life for these women.

虽然恶性肿瘤仍然是一个严重的健康问题，但癌症检测和治疗方面的重大医学进展已经取得进展。 治疗提高了患者的存活率。随着患者寿命的延长，癌症的后果 管理变得更加重要。传统上，癌症患者面临着巨大的 不确定性，并且在保持生育能力方面几乎没有选择。然而，最近的科学进步 使用藻酸盐的三维支架系统用于卵泡的体外成熟 揭示了有前途的临床应用新技术。国家医师协会的使命 合作组织（NPC）组织核心是收集和分发含有卵泡的人类卵巢组织， 肿瘤生育联盟的基础科学组成部分。通过这样做，我们将催化翻译的 在项目RO 1C和生物材料核心（P30 A）中获得的基础科学知识，用于癌症妇女 诊断.全国人大由全国五个核心机构和十五个联盟中心组成。的 该计划的内容包括患者筛查和选择，临床和实验室数据的收集， 卵巢切除术、术后组织处理、跟踪和 卵巢标本的储存和组织分配到参与部位的过程。而且 核心将与社会科学科（RO 1D）密切合作，解决伦理、法律的、经济和社会问题。 社会考虑，将出现从新学科的肿瘤生育。其主要目标是 建议是（1）从患有癌症的妇女中收集成人卵巢，并将其分配用于基本的 科学研究;（2）通过联盟中心教育供应商，患者和社区， 为癌症妇女提供生育选择;（3）传播卵泡成熟的技术知识 和冷冻保存到盟军中心集体目标是最终为生育提供新的选择 保存。全国人大将为基础生殖生理学的突破提供工具 将转化为临床医学，理想情况下，克服许多人面临的不孕症和生育能力低下， 正在接受癌症治疗的妇女。恢复生育能力和其他卵巢功能将大大 提高这些女性的生活质量。