Natl Phys Coop to Preserve Fertility for Female Cancer Patients

国家物理合作社为女性癌症患者保留生育能力

• 批准号: 8133510
• 负责人: R JEFFREY CHANG
• 金额: $ 35.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-29 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8133510
• 关键词: Address; Adult; Alginates; Ally; Basic Science; Biocompatible Materials; Biological Preservation; Cancer Detection; Cancer Patient; Clinical; Clinical Medicine; Collaborations; Collection; Communities; Country; Cryopreservation; Data; Development; Discipline; Drug or chemical Tissue Distribution; Economics; Education; Elements; Ethics; Female; Fertility; Future; Goals; Health; Health Personnel; Human; In Vitro; Infertility; Institutes; Institution; Knowledge; Laboratories; Legal; Life; Malignant Neoplasms; Medical; Mission; Operative Surgical Procedures; Ovarian; Ovarian Follicle; Ovarian Tissue; Ovariectomy; Ovary; Patients; Physicians; Process; Provider; Quality of life; Reproductive Physiology; Research; Scientific Advances and Accomplishments; Screening procedure; Services; Site; Social Sciences; Specimen; Standardization; Survival Rate; System; Techniques; Tissues; Translating; Translations; Uncertainty; Woman; Work; cancer diagnosis; cancer therapy; clinical application; improved; new technology; programs; reproductive; restoration; scaffold; social

Although malignancy remains a critical health concern, significant medical advances in cancer detection and treatment have improved the survival rates for patients. As patients live longer, the consequences of cancer management have assumed greater importance. Traditionally, cancer patients have been faced with great uncertainty and have had few choices for fertility preservation. However, recent scientific advances employing a three-dimensional scaffold system usingx alginate for the in vitro maturation of ovarian follicles reveals promising new technologies for clinical applications. The mission of the National Physicians Cooperative (NPC) Tissue Core is to collect and distribute human ovarian tissue containing follicles to the basic science components of the Oncofertility Consortium. By doing so, we will catalyze the translation of the basic science knowledge gained in project RO1C and the Biomaterial Core (P30A) to women with a cancer diagnosis. The NPC is comprised of five Core institutions and fifteen Allied centers across the country. The elements of this program include patient screening and selection, collection of clinical and laboratory data, standardization of operative techniques for oophorectomy, post-surgical handling of tissues, tracking and storage of ovarian specimens, and a process of tissue distribution to participating sites. Furthermore, the Core will work closely with the social science section (RO1D) to address the ethical, legal, economic, and social considerations that will emerge from the new discipline of Oncofertility. The primary goals of this proposal are (1) to collect adult human ovaries from women with cancer and distribute them for basic science research; (2) to educate providers, patients, and the community through the Allied centers about fertility options for women with cancer; and (3) to disseminate the technical knowledge of follicle maturation and cryopreservation to the Allied centers. The collective goal is to ultimately provide new options for fertility preservation. The NPC will provide the vehicle through which breakthroughs in basic reproductive physiology will be translated to clinical medicine and, ideally, overcome the infertility and subfertility faced by many women undergoing cancer treatment. Restoration of fertility and other ovarian functions would substantially improve the quality of life for these women.

尽管恶性肿瘤仍然是一个严重的健康问题，但在癌症检测和治疗方面的重大医学进展 治疗提高了患者的存活率。随着患者寿命的延长，癌症的后果 管理层承担了更重要的角色。传统上，癌症患者面临着巨大的 不确定，而且几乎没有保留生育能力的选择。然而，最近的科学进步 应用藻酸盐三维支架系统体外成熟卵泡 揭示了临床应用中很有前途的新技术。国家内科医生的使命 合作(NPC)组织核心是收集包含卵泡的人卵巢组织并将其分发给 肿瘤生育联盟的基础科学组成部分。通过这样做，我们将催化翻译 从RO1C项目和生物材料核心(P30A)项目中获得的基本科学知识 诊断。全国人大由全国五个核心机构和十五个盟军中心组成。这个 该计划的内容包括患者筛选和选择、临床和实验室数据的收集、 卵巢切除手术技术的标准化，手术后组织的处理，跟踪和 卵巢标本的保存，以及组织分布到参与部位的过程。此外， CORE将与社会科学部门(RO1D)密切合作，解决伦理、法律、经济和 肿瘤生育这一新学科将产生的社会考量。这个项目的主要目标是 建议是(1)收集患有癌症的妇女的成年卵巢，并将它们分发给基本的 科学研究；(2)通过联合中心教育提供者、患者和社区 癌症妇女的生育选择；以及(3)传播卵泡成熟的技术知识 以及对盟军中心的冷冻保存。共同的目标是最终为生育率提供新的选择 保护。全国人大将提供基本生殖生理突破的载体 将被转化为临床医学，并在理想情况下克服许多人面临的不孕不育和不育症 接受癌症治疗的妇女。恢复生育能力和其他卵巢功能将大大 提高这些妇女的生活质量。