SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们将研究为期12周的运动干预和为期12周的运动加饮食干预对150名目前未服用降压药的高血压患者(血压为140/90 mm Hg，但为179/109 mm Hg)和高血压前期患者(血压为120/80 mm Hg，但为140/90 mm Hg)的炎症和细胞黏附的影响。在干预前后，我们将评估静息和应激(心理应激源和跑台运动试验)循环中CRP、IL-6、TNF-α、sICAM-1、sE-选择素水平的变化，白细胞表面整合素亚单位CD11a和CD11b的表达，白细胞激活(伪足形成)和外周血单核细胞(PBMC)趋化能力的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will examine the effects of a 12-week exercise intervention and a 12-week exercise plus diet intervention on inflammation and cell adhesion in 150 patients with hypertension (blood pressure >140/90 mm Hg but <179/109 mm Hg) and prehypertensive (blood pressure >120/80 mm Hg but <140/90 mm Hg) who are currently not on anti-hypertensive medication. Prior to and following the interventions, we will assess resting and stress-induced (mental stressor and treadmill exercise testing) changes in circulating levels of CRP, IL-6, TNF-alpha, sICAM-1, sE-selectin, expression of the ¿?2-integrin subunits CD11a and CD11b on leukocytes, leukocyte activation (pseudopod formation), and peripheral blood mononuclear cell (PBMC) chemotaxis.