SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION

交感神经系统对细胞粘附的调节

• 批准号: 7724949
• 负责人: Paul J Mills
• 金额: $ 6.37万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724949
• 关键词: Antihypertensive Agents; Blood Pressure; Cell Adhesion; Chemotaxis; Computer Retrieval of Information on Scientific Projects Database; Diet; Exercise; Exercise stress test; Funding; Grant; Hypertension; ITGAM gene; Inflammation; Institution; Integrins; Interleukin-6; Intervention; Leukocytes; Patients; Peripheral Blood Mononuclear Cell; Pharmaceutical Preparations; Psyche structure; Regulation; Research; Research Personnel; Resources; Rest; Selectins; Source; Stress; Sympathetic Nervous System; Tumor Necrosis Factor-alpha; United States National Institutes of Health; Week; cysteine rich protein; human TNF protein; leukocyte activation; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will examine the effects of a 12-week exercise intervention and a 12-week exercise plus diet intervention on inflammation and cell adhesion in 150 patients with hypertension (blood pressure >140/90 mm Hg but <179/109 mm Hg) and prehypertensive (blood pressure >120/80 mm Hg but <140/90 mm Hg) who are currently not on anti-hypertensive medication. Prior to and following the interventions, we will assess resting and stress-induced (mental stressor and treadmill exercise testing) changes in circulating levels of CRP, IL-6, TNF-alpha, sICAM-1, sE-selectin, expression of the ¿?2-integrin subunits CD11a and CD11b on leukocytes, leukocyte activation (pseudopod formation), and peripheral blood mononuclear cell (PBMC) chemotaxis.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们将在150名目前未接受降压药物治疗的高血压（血压>140/90 mm Hg但<179/109 mm Hg）和高血压前期（血压>120/80 mm Hg但<140/90 mm Hg）患者中检查12周运动干预和12周运动加饮食干预对炎症和细胞粘附的影响。在干预前后，我们将评估静息和应激诱导（精神应激和平板运动试验）的CRP、IL-6、TNF-α、sICAM-1、sE-选择素循环水平的变化，2-整联蛋白亚基CD 11 a和CD 11b对白细胞、白细胞活化（伪足形成）和外周血单核细胞（PBMC）趋化性的影响。