SYMPATHETIC NERVOUS SYSTEM EFFECTS ON CELL ADHESION

交感神经系统对细胞粘附的影响

• 批准号: 7374139
• 负责人: Paul J Mills
• 金额: $ 3.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374139
• 关键词: adhesions; cell adhesion; leukocytes; selectins; sympathetic nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine if sympathetic nervous system activation will result in differential effects on cellular adhesion molecules, result in a significant increase in leukocyte transendothelial migration and whether hypertensives will show different patterns of cellular adhesion molecules following sympathetic nervous system activation with a greater decrease in l-selectin expression and with greater rate of leukocyte transendothelial migration.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。确定交感神经系统激活是否会对细胞粘附分子产生不同的影响，导致白细胞跨内皮迁移显着增加，以及高血压患者在交感神经系统激活后是否会表现出不同的细胞粘附分子模式，其中 L-选择素表达量下降幅度更大，白细胞跨内皮迁移率更高。