THE VETSA LONGITUDINAL TWIN STUDY OF COGNITION AND AGING (VETSA2)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Vetsa的总体目标是量化遗传和环境对中年与年龄相关的认知变化的影响。第一波数据收集始于2002年，对1237名参与者进行了成功评估，数据收集工作于2007年10月结束。Vetsa 2有以下目标和假设。 目标1.完成Vetsa 1基线评估：在项目的第一年，我们将评估新的双胞胎，以便使在Vetsa 1开始的基线评估的样本量达到预定的1440对。这将允许在未来的纵向分析中有更大的统计能力。 目的2.描述遗传和环境对认知能力随时间变化的影响：这一目标将给出以下问题的答案：a)遗传和环境因素在多大程度上对成年人(从20岁到65岁)一般认知能力的变化轨迹负责？B)在中年后期，特定的认知过程会发生多大程度的变化？C)由于共同的遗传或环境影响，观察到的不同认知域的变化在多大程度上相关？D)加工速度和工作记忆的组成部分在多大程度上预测认知表现的变化？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of VETSA is to quantify the genetic and environmental influences on age-related cognitive changes in mid-life. Wave 1 of data collection (VETSA 1) began in 2002 and resulted in the successful assessment 1,237 participants with data collection ending in October 2007. VETSA 2 has the following aims and hypotheses. Aim 1. Completion of VETSA 1 baseline assessment: During the first year of the project we will assess new twin pairs in order to bring the sample size for the baseline assessment begun in VETSA 1 to the targeted 1440. This will allow for greater statistical power in future longitudinal analyses. Aim 2. Characterize genetic and environmental influences on cognitive change over time: This Aim will yield answers to the following questions: a) To what extent are genetic and environmental factors responsible for individual trajectories of change in general cognitive ability across adulthood (from age 20 to 65)? b) To what degree do specific cognitive processes change during late middle age? c) To what extent are observed changes in different cognitive domains correlated due to shared genetic or environmental effects? d) To what extent do the components of processing speed and working memory predict changes in cognitive performance?