THE VETSA LONGITUDINAL TWIN STUDY OF COGNITION AND AGING (VETSA2)

VETSA 认知和衰老纵向双胞胎研究 (VETSA2)

• 批准号: 8166888
• 负责人: WILLIAM S. KREMEN
• 金额: $ 0.33万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166888
• 关键词: Adult; Age; Aging; Cognition; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Data Collection; Environmental Risk Factor; Funding; Future; Genetic; Goals; Grant; Individual; Institution; Participant; Performance; Process; Research; Research Personnel; Resources; Sample Size; Short-Term Memory; Source; Time; Twin Multiple Birth; Twin Studies; United States National Institutes of Health; age related cognitive change; cognitive change; middle age; processing speed

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of VETSA is to quantify the genetic and environmental influences on age-related cognitive changes in mid-life. Wave 1 of data collection (VETSA 1) began in 2002 and resulted in the successful assessment 1,237 participants with data collection ending in October 2007. VETSA 2 has the following aims and hypotheses. Aim 1. Completion of VETSA 1 baseline assessment: During the first year of the project we will assess new twin pairs in order to bring the sample size for the baseline assessment begun in VETSA 1 to the targeted 1440. This will allow for greater statistical power in future longitudinal analyses. Aim 2. Characterize genetic and environmental influences on cognitive change over time: This Aim will yield answers to the following questions: a) To what extent are genetic and environmental factors responsible for individual trajectories of change in general cognitive ability across adulthood (from age 20 to 65)? b) To what degree do specific cognitive processes change during late middle age? c) To what extent are observed changes in different cognitive domains correlated due to shared genetic or environmental effects? d) To what extent do the components of processing speed and working memory predict changes in cognitive performance?

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 VETSA的总体目标是量化遗传和环境对中年年龄相关认知变化的影响。 第一波数据收集（VETSA 1）始于2002年，成功评估了1 237名参与者，数据收集于2007年10月结束。 VETSA 2有以下目标和假设。 目标1. 完成VETSA 1基线评估：在项目的第一年，我们将评估新的双胞胎对，以使VETSA 1开始的基线评估的样本量达到目标1440。 这将使未来的纵向分析具有更大的统计功效。 目标2. 描述遗传和环境对认知变化的影响：该目标将回答以下问题：a）遗传和环境因素在多大程度上对成年期（20岁至65岁）一般认知能力的个体变化轨迹负责？ B）在中年晚期，特定的认知过程发生了多大程度的变化？c）在何种程度上，观察到的不同认知领域的变化由于共同的遗传或环境影响而相关？d）加工速度和工作记忆的成分在多大程度上预测认知表现的变化？