MATERNAL CONSUMPTION OF A WESTERN DIET PROMOTES OBESITY-INDUCED CV DISEASE AND D

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 项目3：母亲食用西方饮食会导致后代肥胖和高血压 PI凯文·皮尔森 项目描述： 子宫内环境会影响正在生长的胚胎的发育，不合适的环境可能导致妊娠终止。然而，新的研究表明，更微妙的因素可能会影响后代的长期健康。例如，营养不良的孕妇生育的后代较小，成年后肥胖、糖尿病和心脏病的发病率较高。然而，在西方世界，母亲肥胖是一个日益严重的问题，流行病学研究现在指出其后代的代谢紊乱。考虑到这些发现，该建议的一般假设是，母亲在怀孕和哺乳期间食用西方（高脂肪）饮食将通过激活肾素-血管紧张素系统促进后代的肥胖和高血压，而母亲食用白藜芦醇将阻断负面影响。其目标是详细了解不健康饮食或白藜芦醇的存在引起的断奶前环境变化对小鼠肥胖和心血管疾病的影响。为此，我们将在交配前6周（或交配时）、整个妊娠期以及分娩后14天内对雌性小鼠的饮食组成进行控制。所有组中母亲的后代在断奶后将被喂食正常的低脂饮食。将监测后代的肥胖、葡萄糖和胰岛素耐受性以及高血压。肥胖、糖尿病和心血管疾病已达到流行水平，针对妊娠期的干预措施可能是阻止这一趋势的有效方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project 3: MATERNAL CONSUMPTION OF A WESTERN DIET PROMOTES OBESITY AND HYPERTENSION IN OFFSPRING PI Kevin Pearson PROJECT DESCRIPTION: The intrauterine environment affects the development of the growing embryo and an unsuitable environment can lead to termination of pregnancy. However, emerging research has shown that more subtle factors can potentially influence long-term health in the offspring. For instance, malnourished pregnant mothers produce smaller offspring that have a higher incidence of obesity, diabetes, and heart disease during adulthood. However, in the Western world, maternal obesity is an ever-increasing problem and epidemiology studies are now pointing to metabolic derangements in their offspring. Taking these findings into consideration, the general hypothesis of this proposal is maternal consumption of a Western (high fat) diet during pregnancy and nursing will promote obesity and hypertension in offspring through activation of the renin-angiotensin system, and maternal consumption of resveratrol will block the negative effects. The goal is to gain detailed insights into the effects of pre-weaning environmental changes caused by unhealthy diets, or the presence of resveratrol, on obesity and cardiovascular disease in mice. For this purpose we will manipulate the dietary composition of female mice six weeks prior to mating (or at mating), throughout pregnancy, and until 14 days after giving birth. Offspring from mothers in all groups will then be fed a normal, low-fat diet after weaning. Obesity, glucose and insulin tolerance, and hypertension will be monitored in the offspring. Obesity, diabetes, and cardiovascular disease are at epidemic levels and interventions targeting gestation might be an efficient way to stem the tide.