Maternal Exercise Enhances Cancer Protection in Offspring

描述(由申请人提供)：到目前为止，卡路里限制本身已被证明是改善实验动物癌症结果的最可重复性和最有前途的干预措施。一个密集和不断扩大的研究领域集中在发现容易实现的干预措施，这些干预措施可以产生长期的积极影响。这项提议将探索孕期母体锻炼作为一种潜在的短期干预措施，可以为下一代提供终生受益。在一项对小鼠的小型先导性研究中，与久坐不动的水坝所生的后代相比，运动水坝所生的后代改善了血糖调节，并增强了压力保护。这些初步发现支持了一种假设，即怀孕和哺乳期间的母亲锻炼可以保护成熟的后代免受化学致癌物的伤害，因为抗氧化酶的活性增加了。第一个目标是测试怀孕期间的母亲锻炼是否是一种现实的干预措施，可以保护成熟的后代免受化学致癌物的伤害。第二个目标是阐明应激诱导转录因子--核因子-2红系相关因子2作为围产期运动长期保护的潜在机制所起的作用。这些研究将提供关于母体锻炼可能对子代癌症保护产生的潜在积极影响的重要信息。 公共卫生相关性：运动的益处已被广泛研究，但孕期母体运动对子代长期结局的影响被忽视。其目标是利用小鼠的母体运动作为干预措施，通过增加抗氧化酶的活性来增强后代对癌症的保护。

DESCRIPTION (provided by applicant): To date, caloric restriction has shown itself to be the most reproducible and promising intervention to improve cancer outcomes in laboratory animals. An intense and expanding area of research is focused on discovering easily achievable interventions that can have long-lasting positive effects. This proposal will explore maternal exercise during pregnancy as a potential short-term intervention that can provide a lifetime of benefits for the next generation. In a small pilot study in mice, offspring born to exercised dams had improved glucose regulation and enhanced stress protection compared to offspring born to sedentary dams. These preliminary findings contribute to the hypothesis that maternal exercise during pregnancy and nursing protects mature offspring against chemical carcinogens because of increased activities of antioxidant enzymes. The first aim is designed to test whether maternal exercise during pregnancy is a realistic intervention that can protect mature offspring from chemical carcinogens. The second aim will look to elucidate the role of the stress-induced transcription factor, nuclear factor erythroid-2 related factor 2, as a potential mechanism for long-lasting protection by perinatal exercise. These studies will provide important information on the potential positive impact maternal exercise may have on offspring cancer protection. PUBLIC HEALTH RELEVANCE: The benefits of exercise have been studied extensively, but the effects of maternal exercise during pregnancy on long-term outcomes in offspring have been neglected. The goal is to use maternal exercise in mice as an intervention to increase cancer protection in the offspring through increased activity of antioxidant enzymes.