Maternal Exercise Enhances Cancer Protection in Offspring

母亲锻炼可增强后代的癌症保护

• 批准号: 8398731
• 负责人: Kevin Joseph Pearson
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-09 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8398731
• 关键词: Acetates; Adopted; Adult Children; Anthracenes; Antioxidants; Area; Behavior; Binding; Birth; Breeding; Caloric Restriction; Carcinogens; Cardiovascular Diseases; Cells; Chemicals; Commit; Development; Diabetes Mellitus; Diet; Discipline of Nursing; Drug Metabolic Detoxication; Enzymes; Epidemic; Exercise; Female; Future; Gene Targeting; Generations; Genetic Transcription; Goals; Health; Home environment; Housing; Inbred ICR Mice; Intervention; Laboratory Animals; Litter Size; Liver; Malignant Neoplasms; Measures; Modeling; Mus; Neonatal; Obesity; Outcome; Oxidative Stress; Papilloma; Parents; Partner in relationship; Pathway interactions; Perinatal; Phorbol; Phorbols; Pilot Projects; Pregnancy; Probability; Proteins; Research; Resistance; Response Elements; Role; Running; Signal Transduction; Skin; Skin Tissue; Staging; Stress; Testing; Topical application; Tumor Promoters; Ultraviolet Rays; Very Light Exercise; biological adaptation to stress; blood glucose regulation; carcinogenesis; chemical carcinogen; design; dimethylbenzanthracene; improved; keratinocyte; male; melanocyte; neglect; next generation; novel; nuclear factor-erythroid 2; offspring; response; sedentary; transcription factor; trend; tumor; unborn child

DESCRIPTION (provided by applicant): To date, caloric restriction has shown itself to be the most reproducible and promising intervention to improve cancer outcomes in laboratory animals. An intense and expanding area of research is focused on discovering easily achievable interventions that can have long-lasting positive effects. This proposal will explore maternal exercise during pregnancy as a potential short-term intervention that can provide a lifetime of benefits for the next generation. In a small pilot study in mice, offspring born to exercised dams had improved glucose regulation and enhanced stress protection compared to offspring born to sedentary dams. These preliminary findings contribute to the hypothesis that maternal exercise during pregnancy and nursing protects mature offspring against chemical carcinogens because of increased activities of antioxidant enzymes. The first aim is designed to test whether maternal exercise during pregnancy is a realistic intervention that can protect mature offspring from chemical carcinogens. The second aim will look to elucidate the role of the stress-induced transcription factor, nuclear factor erythroid-2 related factor 2, as a potential mechanism for long-lasting protection by perinatal exercise. These studies will provide important information on the potential positive impact maternal exercise may have on offspring cancer protection. PUBLIC HEALTH RELEVANCE: The benefits of exercise have been studied extensively, but the effects of maternal exercise during pregnancy on long-term outcomes in offspring have been neglected. The goal is to use maternal exercise in mice as an intervention to increase cancer protection in the offspring through increased activity of antioxidant enzymes.

描述（由申请人提供）：迄今为止，热量限制已被证明是改善实验动物癌症结果的最可重复和最有希望的干预措施。一个激烈且不断扩大的研究领域致力于发现易于实现、能够产生持久积极影响的干预措施。该提案将探索母亲在怀孕期间的锻炼作为一种潜在的短期干预措施，可以为下一代带来终生的好处。在一项针对小鼠的小型试点研究中，与久坐的母鼠所生的后代相比，运动的母鼠所生的后代的血糖调节能力得到了改善，应激保护也得到了增强。这些初步发现有助于这样的假设：由于抗氧化酶的活性增加，母亲在怀孕和哺乳期间进行锻炼可以保护成熟的后代免受化学致癌物的侵害。第一个目标是测试母亲在怀孕期间的锻炼是否是一种现实的干预措施，可以保护成熟的后代免受化学致癌物的侵害。第二个目标是阐明应激诱导转录因子、核因子 erythroid-2 相关因子 2 的作用，作为围产期运动持久保护的潜在机制。这些研究将提供有关母亲锻炼可能对后代癌症保护产生潜在积极影响的重要信息。 公共卫生相关性：运动的好处已被广泛研究，但母亲在怀孕期间运动对后代长期结局的影响却被忽视了。目标是利用小鼠的母亲运动作为干预措施，通过增加抗氧化酶的活性来增强后代的癌症保护。