Maternal Exercise Enhances Cancer Protection in Offspring

描述（由申请人提供）：迄今为止，热量限制已被证明是最可重复和最有前途的干预措施，以改善实验室动物的癌症结果。一个密集和不断扩大的研究领域集中在发现容易实现的干预措施，可以产生持久的积极影响。该提案将探讨孕妇在怀孕期间锻炼作为一种潜在的短期干预措施，可以为下一代提供终身的好处。在一项对小鼠的小型试点研究中，与久坐不动的母鼠所生的后代相比，运动母鼠所生的后代改善了葡萄糖调节，增强了压力保护。这些初步研究结果有助于假设，母亲在怀孕和哺乳期间的运动保护成熟的后代免受化学致癌物，因为抗氧化酶的活性增加。第一个目的是测试母亲在怀孕期间锻炼是否是一种现实的干预措施，可以保护成熟的后代免受化学致癌物的影响。第二个目标将寻求阐明应激诱导的转录因子，核因子红细胞-2相关因子2的作用，作为一个潜在的机制，长期持久的保护围产期运动。这些研究将提供重要信息，说明母亲锻炼可能对后代癌症保护产生的潜在积极影响。 公共卫生相关性：运动的益处已被广泛研究，但母亲在怀孕期间运动对后代长期结局的影响却被忽视了。目标是利用小鼠的母体运动作为干预措施，通过增加抗氧化酶的活性来增加后代的癌症保护作用。

DESCRIPTION (provided by applicant): To date, caloric restriction has shown itself to be the most reproducible and promising intervention to improve cancer outcomes in laboratory animals. An intense and expanding area of research is focused on discovering easily achievable interventions that can have long-lasting positive effects. This proposal will explore maternal exercise during pregnancy as a potential short-term intervention that can provide a lifetime of benefits for the next generation. In a small pilot study in mice, offspring born to exercised dams had improved glucose regulation and enhanced stress protection compared to offspring born to sedentary dams. These preliminary findings contribute to the hypothesis that maternal exercise during pregnancy and nursing protects mature offspring against chemical carcinogens because of increased activities of antioxidant enzymes. The first aim is designed to test whether maternal exercise during pregnancy is a realistic intervention that can protect mature offspring from chemical carcinogens. The second aim will look to elucidate the role of the stress-induced transcription factor, nuclear factor erythroid-2 related factor 2, as a potential mechanism for long-lasting protection by perinatal exercise. These studies will provide important information on the potential positive impact maternal exercise may have on offspring cancer protection. PUBLIC HEALTH RELEVANCE: The benefits of exercise have been studied extensively, but the effects of maternal exercise during pregnancy on long-term outcomes in offspring have been neglected. The goal is to use maternal exercise in mice as an intervention to increase cancer protection in the offspring through increased activity of antioxidant enzymes.