MATERNAL CONSUMPTION OF A WESTERN DIET PROMOTES OBESITY-INDUCED CV DISEASE AND D

母亲食用西方饮食会促进肥胖引起的心血管疾病和糖尿病

• 批准号: 8360248
• 负责人: Kevin Joseph Pearson
• 金额: $ 24.46万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360248
• 关键词: Antioxidants; Cardiovascular Diseases; Consumption; Diabetes Mellitus; Diet; Discipline of Nursing; Disease; Epidemic; Fatty acid glycerol esters; Female; Female of child bearing age; Funding; Goals; Grant; Health; Hypertension; Insulin Resistance; Intervention; Measures; Motor; Mus; National Center for Research Resources; Obesity; Organ; Partner in relationship; Pathology; Pregnancy; Principal Investigator; Research; Research Infrastructure; Resources; Resveratrol; Source; Supplementation; United States National Institutes of Health; Weaning; cost; feeding; improved; insulin sensitivity; offspring; red wine; stem

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Sub-project 3 Description Since approximately 30% of child-bearing women (age 20 to 39) in the U.S. are obese, it is critical to define effects of obesity on long-term health in offspring. The goal of this proposal is to find a feasible intervention during pregnancy that can limit the detrimental effects of maternal obesity. One potential candidate is a compound found in red wine, resveratrol. Resveratrol is an antioxidant that has been shown to improve survival, motor function, insulin sensitivity, and organ pathology in mice fed a high fat diet. As a result, the general hypothesis of this proposal is maternal consumption of a western (high fat) diet during pregnancy and nursing will promote obesity, insulin resistance, and hypertension in offspring, and maternal consumption of resveratrol will block the negative effects. For this purpose we will manipulate the dietary composition of female mice prior to mating and throughout pregnancy and nursing. Female mice will be fed either a normal or western diet with or without 0.1% resveratrol supplementation. Obesity, insulin resistance, and hypertension will be measured in mature offspring that will be fed a standard diet from weaning. These studies will provide important new information on the potential negative impact western diet consumption during gestation and nursing may have on long-term offspring health and establish whether resveratrol consumption can protect against these effects. Obesity and diabetes are at epidemic levels and interventions targeting gestation might be an efficient way to stem the tide.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 次级项目3 由于美国约有30%的育龄妇女（20至39岁）肥胖，因此确定肥胖对后代长期健康的影响至关重要。这项提案的目标是在怀孕期间找到一种可行的干预措施，可以限制产妇肥胖的不利影响。一个潜在的候选者是在红葡萄酒中发现的化合物，白藜芦醇。 白藜芦醇是一种抗氧化剂，已被证明可以改善高脂肪饮食小鼠的生存，运动功能，胰岛素敏感性和器官病理学。因此，这项建议的一般假设是，母亲在怀孕和哺乳期间食用西方（高脂肪）饮食将促进后代肥胖，胰岛素抵抗和高血压，母亲食用白藜芦醇将阻断负面影响。为此，我们将在交配前以及整个妊娠和哺乳期间操纵雌性小鼠的饮食组成。雌性小鼠将喂食正常或西方饮食，补充或不补充0.1%白藜芦醇。肥胖、胰岛素抵抗和高血压将在从断奶开始喂食标准饮食的成熟后代中进行测量。这些研究将提供重要的新信息，说明妊娠期和哺乳期西方饮食消费可能对后代长期健康产生的潜在负面影响，并确定白藜芦醇消费是否可以防止这些影响。肥胖和糖尿病已达到流行病的水平，针对妊娠期的干预措施可能是阻止这一趋势的有效方法。