COBRE: MUSC: CORE C: CLINICAL RESOURCES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人员名单 卡洛斯·萨利纳斯，D.M.D.主任 丽莎·萨默林，R.D.H.口腔/牙科检查员 Pam Hudson，R.D.H.口腔/牙科检查员 安·斯穆涅夫斯基行政助理 菲利普·沃纳研究专家III，主管 口腔健康研究中心 Lynn West，硕士临床研究协调员 子项目描述 具体目标 +提供必要的临床和实验室专业知识，以促进实施由口腔健康SC Cobre支持的各种项目。 +为SC Cobre口腔健康中心支持的各种项目协调招募和获得研究对象的机会。 目标 +通过南卡罗来纳医科大学(MUSC)的临床转化研究中心(CTRC)提供集中的门诊牙科诊所研究设施。 +按照Cobre临床方案的要求收集人口统计和其他数据。 +为CTRC及其在农村地区的附属机构的所有Cobre临床研究机构提供经过严格校准的牙科检查员。 +根据特定临床研究方案的要求，收集口腔健康评估数据并将其输入中央计算机数据库(在生物统计核心)。 +收集、加工和分发生物样本以供实验室分析。 +协助项目调查人员进行口腔健康评估、问卷调查和参数选择。 +通过每月会议确保计划合作伙伴之间的协调。 背景与核心相关性 临床资源核心(CORE C)的目的是协调所有Cobre项目的临床和研究活动。为了实现这一目标，CORE C提供必要的临床和实验室专业知识来实施Cobre项目，并促进每月召开会议，以评估成功、需求、挑战和问题的解决方案。核心C对整个COBRE的成功至关重要，因为它协调了在MUSC和国家网络医疗保健地点进行的多个口腔健康研究项目之间的努力并促进了资源的有效利用。 除了其一般协调职能外，CORE C还专门与南加州大学现有的“海岛家庭项目理事会”合作，以提高居住在南卡罗来纳州海岸历史上与世隔绝的屏障岛屿上的非裔美国人的可信度和获得口腔牙科研究项目的机会。这群人构成了一个独特的群体(古拉族)，他们说自己的语言。这一外联活动以及与海岛家庭项目理事会的伙伴关系对双方都是有益的经验。我们直接从社区了解到他们的需求，以及医疗中心和社区之间存在的障碍。南卡罗来纳州的非裔美国人占我们州人口的33%，而全国这一比例为12%。其中不成比例流行的疾病是癌症(包括口腔和咽部)、糖尿病、高血压、中风、药物滥用、抑郁症、肥胖症、不良妊娠结局和这些疾病的相关并发症。居住在南卡罗来纳州的非洲裔美国人之间的口腔健康差异一再被记录在案。一项(1982-1983)全州范围的学龄儿童口腔健康评估发现，大多数(高加索人)和少数人(非裔美国人)儿童之间存在显著的口腔健康差距。最近，《美国口腔健康：卫生局局长2000年的一份报告》中报告的数据描述了一种无声的口腔疾病流行，对美国的穷人和少数族裔人口造成了不成比例的影响。值得注意的是，多项研究发现口腔疾病和系统性疾病之间存在关联。 在评估南卡罗来纳海群岛讲古拉语的人口的口腔健康时，CORE C特别支持旨在从口腔-牙科角度描述这一独特的、历史上与世隔绝的人口的项目。核心C支持在这些社区提供口腔牙科教育的项目，以及那些旨在通过确定龋齿、牙周病、软组织损伤和癌症的流行率来评估这些人口的总体牙科需求的项目。 为了实现支持所有COBRE计划活动的目标，CORE C与现有的MUSC和社区资源建立了大量的合作伙伴关系。与CORE C合作的现有资源包括：NCRR资助的普通临床研究中心(GCRC)(现为临床和转化研究中心(CTRC))、SCOG计划社区伙伴计划、MUSC牙科医学院患者临床人口、MUSC医学中心临床人口和霍林斯癌症中心临床人口。 核心C还协调Cobre项目在广泛地点的活动，包括：CTRC临床转化研究中心牙科诊所和低地国家地区(南卡罗来纳州沿海)的社区卫星诊所网络。其中包括库珀东部社区外展诊所和约翰斯岛上的一家新设施--仁慈圣母外展诊所。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PERSONNEL LIST Carlos Salinas, D.M.D. Director Lisa Summerlin, R.D.H. Oral/Dental Examiner Pam Hudson, R.D.H. Oral/Dental Examiner Ann Smuniewski Administrative Assistant Phillip Werner Research Specialist III, Supervisor Center for Oral Health Research Lynn West, M.A. Clinic Research Coordinator SUBPROJECT DESCRIPTION SPECIFIC AIMS + Provide necessary clinical and laboratory expertise to facilitate implementation of a variety of projects supported by the SC COBRE for Oral Health. + Coordinate recruitment of and access to research subjects for a variety of projects supported by the SC COBRE for Oral Health. OBJECTIVES + Provide a centralized, outpatient dental clinic research facility through the Clinical Translational Research Center (CTRC) at the Medical University of South Carolina (MUSC). + Collect demographic and other data as required by COBRE Clinical Protocols. + Provide dully-calibrated dental examiners for all COBRE Clinical Research at the CTRC and affiliated sites in rural areas. + Collect and enter oral health assessment data as requested by specific clinical research protocols in a centralized computer database (at Biostatistics CORE). + Collect, process and distribute biological samples for laboratory analysis. + Assist project investigators with oral health assessments, questionnaires and parameter selection. + Ensure coordination between program partners through monthly meetings. BACKGROUND  CORE RELEVANCE The purpose of the Clinical Resources CORE (CORE C) is to coordinate the clinical and research activities of all COBRE projects. To accomplish this, CORE C provides the necessary clinical and laboratory expertise to implement COBRE Projects and facilitates monthly meetings to assess successes, needs, challenges and solutions to problems. CORE C is essential to the success of the overall COBRE as it coordinates efforts and facilitates efficient resource use among the multiple oral health research projects conducted at MUSC and at the state network healthcare sites. In addition to its general coordinating functions, CORE C specifically collaborates with MUSC's existing "Sea Island Families Project Council" to improve credibility and access to oro-dental research projects among African-Americans living on the historically isolated barrier islands of the South Carolina coast. This group of persons constitutes a unique group (Gullah population) that speaks their own language. This outreach activity and the partnership with the Sea Island Families Project Council has been a beneficial experience for both parts involved. We have learned directly from the community about their needs as well as the barriers that exist between a medical center and the community. The African Americans in South Carolina comprise ~33% of our state's population compared to ~12% nationally. Diseases that are disproportionately prevalent among them are cancers (including oral and pharyngeal), diabetes, hypertension, stroke, substance abuse, depression, obesity, adverse pregnancy outcomes and the related complications of these disorders. Significant oral health disparities have been repeatedly documented among African American persons living in South Carolina. A (1982-1983) statewide oral health assessment of school-aged children found significant oral health disparities between majority (Caucasian) and minority (African American) children. More recently, data reported in Oral Health in America: A Report of the Surgeon General, 2000 describe a silent epidemic of oral disease disproportionately affecting the nation's poor and minority populations. It is noteworthy that multiple studies find an association between oral dental disease and systemic diseases. In assessing the oral health of the Gullah speaking population on the South Carolina Sea Islands, CORE C specifically supports projects aiming to characterize this unique and historically isolated population from an oro-dental perspective. CORE C supports projects providing oral dental education in these communities as well as those aiming to assess the overall dental needs of this population by determining the prevalence of caries, periodontal disease, soft tissue lesions and cancer. To fulfill its purpose of supporting all COBRE program activities, CORE C has developed substantial partnerships with existing MUSC and community resources. Existing resources that are working in partnership with CORE C include: the NCRR funded General Clinical Research Center (GCRC) now called Clinical and Translational Research Center (CTRC), the Project SUGAR Community Partnership Program, MUSC College of Dental Medicine Patient Clinical Populations, MUSC Medical Center Clinical Populations and the Hollings Cancer Center Clinical Populations. CORE C also coordinates COBRE project activities at a wide range of sites including: the CTRC Clinical Translational Research Center Dental Clinic and a network of community satellite clinics in the Low Country area (Coastal South Carolina). These include the East of Cooper Community Outreach Clinic and Our Lady of Mercy Outreach Clinic, a new facility on Johns Island.