COBRE: MUSC: CORE C: CLINICAL RESOURCES

COBRE：MUSC：核心 C：临床资源

• 批准号: 8167764
• 负责人: Carlos F Salinas
• 金额: $ 35万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167764
• 关键词: Affect; African American; Americas; Area; Biological; Biostatistics Core; Caucasians; Caucasoid Race; Center for Translational Science Activities; Centers of Research Excellence; Child; Clinic; Clinical; Clinical Cancer Center; Clinical Protocols; Clinical Research; Clinical Research Protocols; Communities; Community Networks; Community Outreach; Computer Retrieval of Information on Scientific Projects Database; Computers; Country; Data; Data Reporting; Databases; Dental; Dental Clinics; Dental Education; Dental Research; Dental caries; Diabetes Mellitus; Disease; Ensure; Epidemic; Family; Funding; Grant; Healthcare; Human Resources; Hypertension; Institution; Island; Laboratories; Language; Learning; Lesion; Life; Malignant Neoplasms; Medical; Medical center; Medicine; Mental Depression; Minority; Mouth Diseases; National Center for Research Resources; Obesity; Oral; Oral health; Oropharyngeal; Outpatients; Patients; Periodontal Diseases; Persons; Population; Pregnancy Outcome; Prevalence; Process; Questionnaires; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Research Subjects; Resources; Sampling; School-Age Population; Sea; Site; Solutions; Source; South Carolina; Specialist; Stroke; Substance abuse problem; Surgeon; Systemic disease; Tooth Diseases; United States National Institutes of Health; Universities; Work; college; experience; health disparity; improved; meetings; outreach; programs; research facility; rural area; soft tissue; success; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PERSONNEL LIST Carlos Salinas, D.M.D. Director Lisa Summerlin, R.D.H. Oral/Dental Examiner Pam Hudson, R.D.H. Oral/Dental Examiner Ann Smuniewski Administrative Assistant Phillip Werner Research Specialist III, Supervisor Center for Oral Health Research Lynn West, M.A. Clinic Research Coordinator SUBPROJECT DESCRIPTION SPECIFIC AIMS + Provide necessary clinical and laboratory expertise to facilitate implementation of a variety of projects supported by the SC COBRE for Oral Health. + Coordinate recruitment of and access to research subjects for a variety of projects supported by the SC COBRE for Oral Health. OBJECTIVES + Provide a centralized, outpatient dental clinic research facility through the Clinical Translational Research Center (CTRC) at the Medical University of South Carolina (MUSC). + Collect demographic and other data as required by COBRE Clinical Protocols. + Provide dully-calibrated dental examiners for all COBRE Clinical Research at the CTRC and affiliated sites in rural areas. + Collect and enter oral health assessment data as requested by specific clinical research protocols in a centralized computer database (at Biostatistics CORE). + Collect, process and distribute biological samples for laboratory analysis. + Assist project investigators with oral health assessments, questionnaires and parameter selection. + Ensure coordination between program partners through monthly meetings. BACKGROUND  CORE RELEVANCE The purpose of the Clinical Resources CORE (CORE C) is to coordinate the clinical and research activities of all COBRE projects. To accomplish this, CORE C provides the necessary clinical and laboratory expertise to implement COBRE Projects and facilitates monthly meetings to assess successes, needs, challenges and solutions to problems. CORE C is essential to the success of the overall COBRE as it coordinates efforts and facilitates efficient resource use among the multiple oral health research projects conducted at MUSC and at the state network healthcare sites. In addition to its general coordinating functions, CORE C specifically collaborates with MUSC's existing "Sea Island Families Project Council" to improve credibility and access to oro-dental research projects among African-Americans living on the historically isolated barrier islands of the South Carolina coast. This group of persons constitutes a unique group (Gullah population) that speaks their own language. This outreach activity and the partnership with the Sea Island Families Project Council has been a beneficial experience for both parts involved. We have learned directly from the community about their needs as well as the barriers that exist between a medical center and the community. The African Americans in South Carolina comprise ~33% of our state's population compared to ~12% nationally. Diseases that are disproportionately prevalent among them are cancers (including oral and pharyngeal), diabetes, hypertension, stroke, substance abuse, depression, obesity, adverse pregnancy outcomes and the related complications of these disorders. Significant oral health disparities have been repeatedly documented among African American persons living in South Carolina. A (1982-1983) statewide oral health assessment of school-aged children found significant oral health disparities between majority (Caucasian) and minority (African American) children. More recently, data reported in Oral Health in America: A Report of the Surgeon General, 2000 describe a silent epidemic of oral disease disproportionately affecting the nation's poor and minority populations. It is noteworthy that multiple studies find an association between oral dental disease and systemic diseases. In assessing the oral health of the Gullah speaking population on the South Carolina Sea Islands, CORE C specifically supports projects aiming to characterize this unique and historically isolated population from an oro-dental perspective. CORE C supports projects providing oral dental education in these communities as well as those aiming to assess the overall dental needs of this population by determining the prevalence of caries, periodontal disease, soft tissue lesions and cancer. To fulfill its purpose of supporting all COBRE program activities, CORE C has developed substantial partnerships with existing MUSC and community resources. Existing resources that are working in partnership with CORE C include: the NCRR funded General Clinical Research Center (GCRC) now called Clinical and Translational Research Center (CTRC), the Project SUGAR Community Partnership Program, MUSC College of Dental Medicine Patient Clinical Populations, MUSC Medical Center Clinical Populations and the Hollings Cancer Center Clinical Populations. CORE C also coordinates COBRE project activities at a wide range of sites including: the CTRC Clinical Translational Research Center Dental Clinic and a network of community satellite clinics in the Low Country area (Coastal South Carolina). These include the East of Cooper Community Outreach Clinic and Our Lady of Mercy Outreach Clinic, a new facility on Johns Island.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 人员名单 医学博士卡洛斯萨利纳斯 主任 丽莎萨默林，R.D.H. 口腔/牙科检查员 帕姆·哈德逊，R.D.H. 口腔/牙科检查员 安·索涅夫斯基 行政助理 菲利普·沃纳 研究专员III，主管 口腔健康研究中心 林恩韦斯特，文学硕士 临床研究协调员 子项目说明 具体目标 + 提供必要的临床和实验室专业知识，以促进由SC COBRE口腔健康支持的各种项目的实施。 + 协调由SC COBRE口腔健康支持的各种项目的研究对象的招募和访问。 目标 + 通过南卡罗来纳州医科大学（MUSC）的临床转化研究中心（CTRC）提供集中的门诊牙科诊所研究设施。 + 根据COBRE临床方案的要求收集人口统计学和其他数据。 + 为CTRC和农村地区附属研究中心的所有COBRE临床研究提供校准良好的牙科检查员。 + 根据特定临床研究方案的要求，收集并将口腔健康评估数据输入中央计算机数据库（位于Biostatistics CORE）。 + 收集、处理和分发生物样本，供实验室分析。 + 协助项目研究人员进行口腔健康评估、问卷调查和参数选择。 + 通过月度会议确保项目合作伙伴之间的协调。 背景  的核心适用性相关 临床资源核心（CORE C）的目的是协调所有COBRE项目的临床和研究活动。 为了实现这一目标，CORE C提供必要的临床和实验室专业知识来实施COBRE项目，并促进每月会议，以评估成功，需求，挑战和问题的解决方案。 CORE C对整个COBRE的成功至关重要，因为它协调了在MUSC和国家网络医疗保健站点进行的多个口腔健康研究项目的工作并促进了资源的有效利用。 除了一般的协调功能，CORE C特别与MUSC现有的“海岛家庭项目理事会”合作，以提高生活在南卡罗来纳州海岸历史上孤立的屏障岛屿上的非洲裔美国人的信誉和获得口腔牙科研究项目。 这一群体构成了一个讲自己语言的独特群体（Gullah人口）。 这一外联活动以及与海岛家庭项目理事会的伙伴关系对参与的双方都是有益的经验。 我们直接从社区了解他们的需求以及医疗中心和社区之间存在的障碍。 南卡罗来纳州的非洲裔美国人占我们州人口的33%，而全国人口占12%。 在这些妇女中发病率过高的疾病是癌症（包括口腔癌和咽癌）、糖尿病、高血压、中风、药物滥用、抑郁症、肥胖症、不良妊娠结局和这些疾病的相关并发症。 在居住在南卡罗来纳州的非洲裔美国人中，已经多次记录了显著的口腔健康差异。 一项（1982-1983年）全州学龄儿童口腔健康评估发现，大多数（白人）和少数民族（非洲裔美国人）儿童之间的口腔健康差异显着。 最近，《美国口腔健康：2000年外科医生报告》中报告的数据描述了一种无声的口腔疾病流行病，不成比例地影响着美国的穷人和少数民族人口。值得注意的是，多项研究发现口腔疾病与全身性疾病之间存在关联。 在评估南卡罗来纳州海岛上说古拉语的人口的口腔健康时，CORE C特别支持旨在从口腔牙科角度描述这一独特和历史上孤立的人口的项目。 CORE C支持在这些社区提供口腔牙科教育的项目，以及旨在通过确定龋齿、牙周病、软组织病变和癌症的患病率来评估这一人群总体牙科需求的项目。 为了实现其支持所有COBRE计划活动的目的，CORE C与现有的MUSC和社区资源建立了实质性的合作伙伴关系。 与CORE C合作的现有资源包括：NCRR资助的一般临床研究中心（GCRC），现称为临床和转化研究中心（CTRC），项目SUGAR社区合作计划，MUSC牙科医学院患者临床人群，MUSC医疗中心临床人群和Hollings癌症中心临床人群。 CORE C还在广泛的地点协调COBRE项目活动，包括：CTRC临床转化研究中心牙科诊所和低地地区（沿海南卡罗来纳州）的社区卫星诊所网络。 其中包括东库珀社区外展诊所和圣母慈悲外展诊所，一个新的设施在约翰斯岛。