COBRE: MUSC: CORE C: CLINICAL RESOURCES

COBRE：MUSC：核心 C：临床资源

• 批准号: 8360483
• 负责人: Carlos F Salinas
• 金额: $ 32.21万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-09-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360483
• 关键词: Adoption; Affect; Africa; African; African American; Agreement; Americas; Applications Grants; Biological; Cancer Center; Center for Translational Science Activities; Centers of Research Excellence; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Research Protocols; Clinical Sciences; Communities; Community Health Centers; Community Outreach; Community Services; Data; Data Analyses; Data Collection; Data Reporting; Dental; Dental Care Delivery; Dental Clinics; Dental caries; Diabetes Mellitus; Discipline; Discipline of Nursing; Disease; Endocrinology; Ensure; Epidemic; Faculty; Family; Floor; Fostering; Funding; Goals; Grant; Healthcare; Hypertension; Immunology; Institutional Review Boards; Interdisciplinary Study; Island; Laboratories; Language; Learning; Lesion; Life; Location; Lupus Erythematosus; Malignant Neoplasms; Manuscripts; Medical Genetics; Medical center; Medicine; Mental Depression; Mentors; Minority; Mouth Diseases; NCI Scholars Program; National Center for Research Resources; Obesity; Oral health; Oropharyngeal; Outcome; Outpatients; Participant; Patients; Periodontal Diseases; Population; Pregnancy Outcome; Preparation; Prevalence; Principal Investigator; Process; Protocols documentation; Reporting; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Rheumatology; Rice; Sampling; Sea; Site; Source; South Carolina; Stroke; Substance abuse problem; Surgeon; Systemic disease; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; base; college; community setting; cost; cost effective; design; diabetes mellitus genetics; experience; health disparity; improved; interest; malignant mouth neoplasm; meetings; member; outreach; programs; protocol development; soft tissue

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. SUBPROJECT DESCRIPTION SPECIFIC AIMS: + To provide space and support for researchers interested in conducting clinical oral health research at MUSC; + To engage more College of Dental Medicine (CDM) faculty members in clinical and translational research; + To stimulate new research discoveries through community-based research, therefore, facilitating the translation and adoption of new research findings into the community settings. OBJECTIVES + To provide an outpatient dental clinic research capacity to support all university projects; + To collect demographic and other data as required by the different clinical research protocols; + To provide calibrated dental examination and dental care delivery as required by the different clinical research protocols; + To collect and enter oral health assessment data as requested by specific clinical research protocols; + To collect, process and distribute biological samples for laboratory analysis; + Assist oral health investigators with clinical / IRB protocol development, participant recruitment, data collection, data analysis, manuscript / grant preparations; + To ensure coordination between program partners through monthly meetings; + To engage academic-community partnerships, transforming oral health care and eliminating oral health disparities in our communities; + To improve the oral health outcomes of the population of South Carolina through discoveries translated into community service; + To establish mechanisms to sustain the progress of community-based initiatives. BACKGROUND  CORE RELEVANCE The Core C goal is to foster clinical and translational oral health research in a cost effective manner, therefore helping to strength the discipline of clinical and translational science. To accomplish this, Core C provides the necessary clinical expertise to implement different research protocols; facilitates grant application process for clinical investigators; and mentors clinical investigators in clinical study design and protocol development. Core C has established a second location, on the 5th floor of the James B. Edward CDM, as well as maintained the one within the MUSC Clinical and translational Research Center (CTRC), allowing the core to support interdisciplinary research projects. The CDM has formal agreements signed with two local community outreach dental clinics, the Our Lady of Mercy Outreach Community Dental Clinical, in Johns Island and the East of the Cooper Community Outreach Dental Clinical, in Mount Pleasant, that can be used as off-site facilities, facilitating patient/participant recruitment and community engagement. The Clinical Core collaborates with the existing MUSC "Sea Island Families Project Council", improving credibility and access of oral health research projects among African-Americans living along the Southeastern U.S. sea costal regions. The African American Gullah population are a direct descendant population of rice plantation enslaved Africans from West Africa. Gullah refers to several things: language, people, and a culture. This outreach activity and the partnership with the Sea Island Families Project Council has been a beneficial experience for both parts involved. We have learned directly from the community about their needs as well as the barriers that exist between a medical center and the community. The African Americans in South Carolina comprise ~33% of our state's population compared to ~12% nationally. Diseases that are disproportionately prevalent among them are cancers (including oral and pharyngeal), diabetes, periodontal disease, hypertension, stroke, substance abuse, depression, obesity, adverse pregnancy outcomes and the related complications of these disorders. Data reported in Oral Health in America: A Report of the Surgeon General, 2000 describe a silent epidemic of oral disease disproportionately affecting the nation's poor and minority populations. It is noteworthy that multiple studies find an association between oral and systemic diseases. The Core supports projects aiming to characterize this unique and historically isolated population from an oral health perspective, by assessing the prevalence of caries, periodontal disease, soft tissue lesions and oral cancer. Core C also supports projects assessing the overall dental needs and the barriers to oral health care specific to this population, guiding the design of culture sensitive community-based clinical projects. To fulfill its purpose of supporting interdisciplinary, community-based oral health research, Core C has developed substantial partnerships with existing MUSC and community resources, such as: Project SUGAR Community Partnership Program; MUSCLE (MUSC Lupus Erythematosus) Research Group; College of Medicine (COM) Division of Endocrinology, Diabetes and Medical Genetics; COM Division of Rheumatology and Immunology; Hollywood, SC mayor's office; Our Lady of Mercy Community Outreach Clinic; MUSC Center for Community Health Partnerships (CCHP); CCHP Community-Engaged Scholars Program; MUSC Hollings Cancer Center; MUSC College of Nursing; and the NCRR's CTSA funded South Carolina Clinical and Translational Research Institute (SCTR).

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 子项目描述的具体目标： +为有兴趣在南加州大学进行临床口腔健康研究的研究人员提供空间和支持； +聘请更多牙科医学院(CDM)教员参与临床和翻译研究； +通过以社区为基础的研究激发新的研究发现，因此，促进将新的研究成果转化和采用到社区环境中。 目标 +提供门诊牙科诊所研究能力，以支持所有大学项目； +收集不同临床研究方案所需的人口学和其他数据； +按照不同的临床研究方案的要求，提供校准的牙科检查和牙科护理服务； +按照特定临床研究方案的要求收集和输入口腔健康评估数据； +收集、处理和分发供实验室分析的生物样本； +协助口腔健康研究人员制定临床/内部评审方案、招募参与者、收集数据、分析数据、准备稿件/赠款； +通过每月会议确保方案伙伴之间的协调； +参与学术-社区伙伴关系，改变口腔保健，消除社区中的口腔健康差距； +通过将发现转化为社区服务，改善南卡罗来纳州人口的口腔健康结果； +建立机制，以维持社区倡议的进展。 背景与核心相关性 核心C目标是以成本效益的方式促进临床和转化性口腔健康研究，从而帮助加强临床和转化性科学的学科。为了实现这一目标，Core C提供必要的临床专业知识来实施不同的研究方案；促进临床研究人员的拨款申请程序；并在临床研究设计和方案开发方面指导临床研究人员。 CORE C在詹姆斯·B·爱德华清洁发展机制的5楼建立了第二个地点，并在MUSC临床和翻译研究中心(CTRC)内维持了一个地点，使核心能够支持跨学科研究项目。清洁发展机制与两家当地社区外展牙科诊所签署了正式协议，即约翰斯岛的仁慈圣母外展社区牙科诊所和芒特普莱森的库珀社区外展牙科诊所以东，可用作场外设施，促进患者/参与者的招募和社区参与。 临床核心与现有的MUSC“海岛家庭项目理事会”合作，提高居住在美国东南部沿海地区的非裔美国人的口腔健康研究项目的可信度和可及性。非洲裔美国人古拉人是来自西非的被稻米种植园奴役的非洲人的直系后裔。古拉指的是几种东西：语言、民族和文化。这一外联活动以及与海岛家庭项目理事会的伙伴关系对双方都是有益的经验。我们直接从社区了解到他们的需求，以及医疗中心和社区之间存在的障碍。南卡罗来纳州的非裔美国人占我们州人口的33%，而全国这一比例为12%。其中不成比例流行的疾病是癌症(包括口腔和咽部)、糖尿病、牙周病、高血压、中风、药物滥用、抑郁症、肥胖症、不良妊娠结局和这些疾病的相关并发症。2000年发表在《美国口腔健康》杂志上的数据：卫生局局长的一份报告描述了一种无声的口腔疾病流行，这种疾病对美国的穷人和少数民族人口造成了不成比例的影响。值得注意的是，多项研究发现口腔疾病和全身疾病之间存在联系。核心支持的项目旨在通过评估龋齿、牙周病、软组织损伤和口腔癌的患病率，从口腔健康的角度描述这一独特的和历史上与世隔绝的人群的特征。CORE C还支持评估整体牙科需求的项目，以及针对这一人群的口腔保健障碍，指导对文化敏感的社区临床项目的设计。 为了实现支持跨学科、以社区为基础的口腔健康研究的宗旨，Core C与MUSC和现有的社区资源建立了实质性的合作伙伴关系，如：MUSC社区合作伙伴计划；MUSC红斑狼疮研究小组；医学院内分泌学、糖尿病和医学遗传学研究部；风湿病和免疫科；好莱坞，SC市长办公室；仁慈夫人社区外联诊所；MUSC社区健康合作中心(CCHP)；CCHP社区参与式学者计划；MUSC Holling癌症中心；MUSC护理学院；以及NCRR的CTSA资助的南卡罗来纳州临床和跨国研究所(SCTR)。