IMPACT OF MATERNAL OBESITY AND DIETARY EXCESS ON FETAL ADIPOSITY

母亲肥胖和饮食过量对胎儿肥胖的影响

• 批准号: 8167813
• 负责人: NATHAN P LONG
• 金额: $ 12.41万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167813
• 关键词: 3 year old; Adipocytes; Adipose tissue; Angiogenic Factor; Animal Model; Arteries; Birth Weight; Blood Pressure; Blood Vessels; Body Composition; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Data; Deposition; Development; Diet; Fatty Acids; Fatty acid glycerol esters; Funding; Grant; Growth; Hormones; Hypertension; Institution; Insulin Resistance; Life; Muscle; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Organ; Physiological; Pregnancy; Property; Research; Research Personnel; Resistance; Resources; Sheep; Skeletal Muscle; Source; Tissues; United States National Institutes of Health; Weight; Woman; angiogenesis; comparative; dietary excess; fatty acid transport; feeding; fetal; fetal blood; insight; mortality; neonatal morbidity; offspring; postnatal; receptor; research study; skeletal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Maternal obesity (MO) is a major cause if fetal and neonatal morbidity and mortality. Increased pre-pregnancy maternal weight in women correlates with increased offspring weight and the potential for persistent and damaging consequences resulting from changes in body composition and developing tissue and organ function. A recent NIDDK and NHLBI RFA acknowledges that animal models of MO are needed to gain insight into the physiologic consequences. We hypothesize that MO and a highly palatable obesogenic diet (HPD) in sheep: 1) increases fatty acid transport from the maternal to the fetal compartment resulting in increased fetal fat deposition, 2) shifts vascular development away from skeletal muscle towards adipose tissue depots through alterations in angiogenesis and vascular reactivity, 3) increases fetal fat to lean body mass which will result in obesity, insulin resistance and hypertension in offspring in postnatal life. Experiment 1 will characterize the impacts of MO/HPD on fetal hormone levels and fatty acid profiles in fetal blood and adipose tissue depots, and evaluate maternal diet-induced changes in vascularity, fatty acid transport activity and adipocyte characteristics in selected fetal fat depots. Experiment 2 will determine the Impact of MO/HPD on fetal adipose and skeletal muscle tissue angiogenic factor/receptor activity and relate these data to comparative vascularity, as well as evaluate alterations in the contractile/relaxant properties of resistance arteries supplying adipose tissue and skeletal muscle. Experiment 3 will compare postnatal characteristics of lambs born to MO/HPD and Control fed ewes, including lamb birth weight and morphometrics, adiposity, growth rate, hormone secretion profiles, insulin resistance and blood pressures to 3 years of age.

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