Radiation Biology

放射生物学项目的重点是放射治疗的有效性可以 提高肿瘤局部控制率和癌症患者存活率。目前有三种不同的方法 为实现这一目标所追求的：1)开发药理和生物制剂，以结合 放疗和化疗，以改善局部肿瘤控制和防止转移扩散； 2)设计实施放射治疗或综合治疗的新方法，以进行临床试验 试验；3)使用酵母和哺乳动物遗传学确定影响反应的遗传决定因素 肿瘤的放射或化疗和放射的结合。 对计划成员的研究产生了一系列重要的发现，包括 P53靶基因PRL-3(再生肝磷酸酶-3)的鉴定 引起细胞间极性的分子途径，开发新的低氧特异性细胞毒素 对于癌症治疗，识别对适应压力至关重要的新基因，这些新基因对 转移，阐明整合DNA损伤识别、检查点的信号通路 信号和DNA修复，研究体内应激反应和靶向小鼠模型的产生 治疗，扩大使用亚分割放射外科治疗实体肿瘤，开发新的 产生治疗用质子和开发分子和功能成像的方法 指导放射治疗的技术。代表该学院的26名项目成员 医学和人文科学学院由同行评议的研究和 培训补助金总计6,826,435美元，包括16架R01，2P01，2架T32。这项计划的成员是 在他们的目标中具有高度的积极性和互动性，在实验室和 开发它们以提高放射治疗的疗效，以控制肿瘤的生长和转移。

The Program in Radiation Biology is focused on ways in which the effectiveness of radiotherapy can increase local tumor control and survival of cancer patients. Three different approaches are being pursued to achieve this goal: 1) Develop pharmacologic and biologic agents to combine with radiotherapy and chemotherapy to improve local tumor control and prevent metastatic spread; 2) Design new approaches to administer radiotherapy or combined modality therapy to test in clinical trials; 3) Identify genetic determinants using yeast and mammalian genetics that influence the response of tumors to radiation or the combination of chemotherapy and radiation. The research of program members has resulted in a series of important findings that include the identification of Prl-3 (phosphatase of regenerating liver-3) as a p53 target gene, the identification of the molecular pathways that give rise to intercellular polarity, developing new hypoxic-specific cytotoxins for cancer therapy, identifying new genes that are essential for adaptation to stress that are essential for metastasis, elucidating the signaling pathways that integrate DNA damage recognition, checkpoint signaling and DNA repair, generation of mouse models to study in vivo stress responses and targeted therapy, expanding the use of hypofractionated radiosurgery to treat solid tumors, developing new approaches to generate protons for therapeutic use and developing molecular and functional imaging techniques to direct the delivery of radiotherapy. The 26 program members representing the School of Medicine and the School of Humanities and Sciences are supported by peer-reviewed research and training grants totaling $6,826,435, including 16 R01s, 2P01s, 2 T32s. The members of this program are highly motivated and interactive in their goal to take fundamental discoveries in the laboratory and develop them to increase the efficacy of radiotherapy to control tumor growth and metastasis.