Tissue Procurement

组织采购机构(TPF)共享资源的总体目标是采购并向斯坦福癌症中心研究人员提供所需的组织标本，以支持他们的癌症相关研究。TPF的活动和服务包括从多余的手术材料和尸检中收集和储存新鲜冷冻的肿瘤和正常组织，为活细胞研究提供新鲜的肿瘤组织，处理和储存癌症患者的血液样本(血浆、血清、白细胞DNA)，维护与临床病理数据相链接的组织数据库，提供组织染色和病理审查，并协调患者的同意和确保监管合规。作为一个集中的共享资源，TPF通过经验、效率、标准化、问责制、保护患者的机密性和及时完成研究来增加价值。监督委员会就设施政策和活动提供建议，并进行科学和后勤审查 服务请求。虽然主要由癌症中心和医学院资助，但运营成本是由适度的使用费支付的。仅在过去的12个月里，TPF就向来自八个癌症中心项目的25名癌症中心研究人员提供了450多个新鲜和冷冻组织样本，以支持不同领域的前沿癌症研究，包括癌症基因组学、癌症干细胞和分子成像。TPF还提供了一个“虚拟银行”的门户，连接专门的“卫星”储存库的库存，包括血液学和神经外科标本的收集。未来的计划包括增加标本采集以满足日益增长的研究人员的需求，并扩大新的石蜡块收集。

The overall objective of the Tissue Procurement Facility (TPF) Shared Resource is to procure and provide needed tissue specimens to Stanford Cancer Center investigators to support their cancer-related research. TPF activities and services include collecting and banking freshly frozen tumor and normal tissue from excess surgical material and from autopsy, providing fresh tumor tissue for viable cell studies, processing and banking blood specimens (plasma, serum, leukocyte DNA) from cancer patients, maintaining a tissue database with links to clinicopathological data, providing histological staining and pathological review and coordinating patient consent and ensuring regulatory compliance. As a centralized shared resource, the TPF adds value through experience, efficiency, standardization, accountability, protection of patient confidentially and timely completion of research. An oversight committee provides recommendations on facility policies and activities, and performs scientific and logistical review of service requests. Though largely supported by the Cancer Center and the School of Medicine, operating costs are defrayed by modest user fees. In the past 12 months alone, the TPF has provided over 450 fresh and frozen tissue specimens to 25 Cancer Center investigators from eight Cancer Center programs, to support cutting-edge cancer research in diverse areas, including cancer genomics, cancer stem cells and molecular imaging. The TPF also provides a portal to a "virtual bank" linking inventories of specialized "satellite" repositories, including collections of hematological and neurosurgical specimens. Future plans include increasing specimen capture to meet growing investigator needs, and expanding a new paraffin block collection.