TURNER SYNDROME: LINKING GENES, BRAIN AND BEHAVIOR

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 简介： 特纳综合征（TS）为阐明X染色体基因功能、脑发育和认知之间的关键联系提供了一个模型。 具体目标： 确定与对照组相比，TS女孩的视觉空间技能、情绪处理和执行功能障碍的神经生物学和遗传学相关性。 研究方法： 对100名TS受试者和50名年龄匹配的女性对照者进行认知行为和神经影像学评估（包括体积MRI、功能MRI、DTI和1H MRS）。 在12 - 18个月时对受试者进行重新评估。 当地受试者还参加旨在改善视觉空间规划或数学技能的认知干预计划。 参与干预计划的受试者在干预前后进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Turner syndrome (TS) provides a model for elucidating critical linkages among X chromosome gene function, brain development, and cognition. Specific Aims: To determine the neurobiologic and genetic correlates of visual-spatial skills, emotion processing and executive function impairments in girls with TS compared to controls. Methods: Cognitive-behavioral and neuroimaging assessments (including volumetric MRI, functional MRI, DTI and 1H MRS) are administered to 100 subjects with TS and 50 age matched female controls. Subjects are re-assessed at 12-18 months. Local subjects additionally participate in cognitive intervention programs designed to improve visual-spatial planning or math skills. Subjects enrolled in the intervention programs are assessed before and after the intervention.