TURNER SYNDROME: LINKING GENES, BRAIN AND BEHAVIOR

特纳综合症：基因、大脑和行为的联系

• 批准号: 8169846
• 负责人: SHELLI R KESLER
• 金额: $ 1.23万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169846
• 关键词: Age; Behavioral; Brain; Cognition; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Development; Emotions; Enrollment; Female; Functional Magnetic Resonance Imaging; Funding; Genes; Genetic; Grant; Impairment; Institution; Intervention; Link; Magnetic Resonance Imaging; Methods; Modeling; Process; Research; Research Personnel; Resources; Source; Turner' s Syndrome; United States National Institutes of Health; Visuospatial; X Chromosome; brain behavior; design; executive function; gene function; girls; improved; intervention program; neuroimaging; skills

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Turner syndrome (TS) provides a model for elucidating critical linkages among X chromosome gene function, brain development, and cognition. Specific Aims: To determine the neurobiologic and genetic correlates of visual-spatial skills, emotion processing and executive function impairments in girls with TS compared to controls. Methods: Cognitive-behavioral and neuroimaging assessments (including volumetric MRI, functional MRI, DTI and 1H MRS) are administered to 100 subjects with TS and 50 age matched female controls. Subjects are re-assessed at 12-18 months. Local subjects additionally participate in cognitive intervention programs designed to improve visual-spatial planning or math skills. Subjects enrolled in the intervention programs are assessed before and after the intervention.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 特纳综合征(TS)为阐明X染色体基因功能、脑发育和认知之间的关键联系提供了一个模型。 具体目标： 确定与对照组相比，患有TS的女孩的视觉空间技能、情绪处理和执行功能障碍的神经生物学和遗传学相关性。 方法： 对100例TS患者和50例年龄匹配的女性对照组进行了认知行为和神经影像检查(包括容量MRI、功能MRI、DTI和1H MRS)。受试者在12-18个月时被重新评估。当地受试者还会参加旨在提高视觉空间规划或数学技能的认知干预计划。对参加干预计划的受试者在干预前后进行评估。