BILATERAL DYNAMIC CONTRAST-ENHANCED BREAST MRI

双侧动态对比增强乳腺 MRI

• 批准号: 8169833
• 负责人: Brian Andrew Hargreaves
• 金额: $ 1.85万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169833
• 关键词: Bilateral; Breast; Clinical; Computer Retrieval of Information on Scientific Projects Database; Estrogens; Fatty acid glycerol esters; Funding; Goals; Grant; Hospitals; Image; Institution; Magnetic Resonance Imaging; Methods; Morphologic artifacts; Motion; Patients; Protocols documentation; Research; Research Personnel; Resolution; Resources; Scanning; Slice; Source; United States National Institutes of Health; Visit; Weight; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: The goal of this project is to transition the current unilateral clinical breast MRI protocol at Stanford Hospital to a complete bilateral protocol. The advantages are reduction of patient visits, and ability to compare contrast uptake in both breasts without confounding due to varied estrogen levels on different exam days. Methods: This protocol combines high-resolution static 3D scanning with rapid lower-resolution dynamic scanning. Both T1-weighted sequences are being expanded to bilateral imaging. The high resolution protocol scans a 3D volume including both breasts in about 6 minutes, with 0.5x1x1.5mm resolution, using a spectral spatial excitation for fat suppression, a partial-echo (A/P) to reduce motion artifacts and parallel-imaging (ARC) in the slice direction to accelerate imaging. The dynamic scans use 3D spiral imaging with dual-slab spectral spatial excitation to further increase scan efficiency, and parallel imaging (TSENSE, see other projects) to further accelerate scans to 10 seconds per 3D frame with 1x1x3 mm resolution. Summary: Bilateral imaging will soon replace the current unilateral scan protocol at the Stanford Hospital. This has numerous advantages including reduced patient visits and the ability to compare contrast uptake in both breasts.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：该项目的目标是将斯坦福医院目前的单侧临床乳腺MRI方案转变为完整的双边方案。其优点是减少了患者的就诊次数，并且能够比较两个乳房的对比吸收情况，而不会因为不同检查日的雌激素水平不同而产生混淆。 方法：该协议将高分辨率静态3D扫描与快速低分辨率动态扫描相结合。两个T1加权序列都被扩展到双侧成像。高分辨率扫描协议以0.5x1x1.5 mm的分辨率在大约6分钟内扫描包括两个乳房在内的3D体积，使用光谱空间激励进行脂肪抑制，使用部分回波(A/P)来减少运动伪影，并在切片方向上使用并行成像(ARC)来加速成像。动态扫描使用双平板光谱空间激发的3D螺旋成像，以进一步提高扫描效率，并使用并行成像(TSENSE，请参阅其他项目)，以1x1x3 mm的分辨率将扫描速度进一步加快至每3D帧10秒。 摘要：在斯坦福医院，双侧成像将很快取代目前的单侧扫描方案。这有许多优点，包括减少病人就诊，以及能够比较两个乳房的对比度吸收。