BILATERAL DYNAMIC CONTRAST-ENHANCED BREAST MRI

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 目的：本项目的目标是将斯坦福大学医院当前的单侧临床乳腺MRI方案转换为完整的双侧方案。 其优点是减少了患者就诊，并且能够比较两个乳房的造影剂摄取，而不会因不同检查日的雌激素水平不同而造成混淆。 方法：该方案将高分辨率静态3D扫描与快速低分辨率动态扫描相结合。 两种T1加权序列都被扩展到双侧成像。 高分辨率协议在大约6分钟内扫描包括两个乳房的3D体积，分辨率为0.5x1x1.5mm，使用频谱空间激励进行脂肪抑制，部分回波（A/P）减少运动伪影，并在切片方向上进行平行成像（ARC）以加速成像。 动态扫描使用3D螺旋成像和双板光谱空间激发，以进一步提高扫描效率，并使用并行成像（TSENSE，参见其他项目），以进一步加速扫描到每3D帧10秒，分辨率为1x 1x 3 mm。 摘要：在斯坦福大学医院，双侧成像将很快取代目前的单侧扫描方案。 这具有许多优点，包括减少患者就诊和比较两个乳房中的造影剂摄取的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: The goal of this project is to transition the current unilateral clinical breast MRI protocol at Stanford Hospital to a complete bilateral protocol. The advantages are reduction of patient visits, and ability to compare contrast uptake in both breasts without confounding due to varied estrogen levels on different exam days. Methods: This protocol combines high-resolution static 3D scanning with rapid lower-resolution dynamic scanning. Both T1-weighted sequences are being expanded to bilateral imaging. The high resolution protocol scans a 3D volume including both breasts in about 6 minutes, with 0.5x1x1.5mm resolution, using a spectral spatial excitation for fat suppression, a partial-echo (A/P) to reduce motion artifacts and parallel-imaging (ARC) in the slice direction to accelerate imaging. The dynamic scans use 3D spiral imaging with dual-slab spectral spatial excitation to further increase scan efficiency, and parallel imaging (TSENSE, see other projects) to further accelerate scans to 10 seconds per 3D frame with 1x1x3 mm resolution. Summary: Bilateral imaging will soon replace the current unilateral scan protocol at the Stanford Hospital. This has numerous advantages including reduced patient visits and the ability to compare contrast uptake in both breasts.