GAINS & LOSSES OF REMEMBERING AMIDST REWARD AND INTERFERENCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 众所周知，陈述性记忆的形成既受到竞争记忆的干扰，也受到动机因素的影响，比如对奖励的预期。虽然干扰对情景编码有有害的影响，并经常引起左前额叶腹外侧皮质(VLPFC)的激活，但最近的研究表明，奖赏预期通过参与中脑边缘结构来促进编码。尽管奖赏预期和干扰的存在有不同的影响，但各自参与的神经系统之间的相互作用程度仍然不清楚。在本研究中，我们使用功能磁共振成像来表征配对联想记忆任务中与奖励预期和助记干扰相关的神经反应。在扫描过程中，每个配对的联想编码试验的前面都有一个提示，表明如果这对组合稍后能被记住的话，可能会有什么奖励(无论是高奖励试验还是低奖励试验)。此外，虽然有些配对完全是新的，但其他配对包含了以前与其他刺激相关的元素(分别是无干扰试验和干扰试验)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Declarative memory formation is known to be influenced both by interference from competing memories as well as motivational factors such as the anticipation of reward. While interference has a deleterious effect on episodic encoding and frequently elicits activation in left ventrolateral prefrontal cortex (VLPFC), reward anticipation has recently been shown to facilitate encoding through engagement of mesolimbic structures. Although reward anticipation and the presence of interference have distinct effects, the extent of interactions between the neural systems engaged by each remains unclear. In the present study, we used functional MRI to characterize neural responses related to reward anticipation and mnemonic interference in the context of a paired associate memory task. During scanning, each paired associate encoding trial was preceded by a cue indicating the potential reward if the pair could be later remembered (either 'high' or 'low' reward trials). Moreover, while some pairs were entirely novel, others contained elements previously associated with other stimuli (no interference vs. interference trials, respectively).