BED-SIDE MONITORING OF TRAUMATIC BRAIN INJURY AND STROKE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 适用于因脑外伤(TBI)或蛛网膜下腔而遭受神经创伤的患者 出血(SAH)时，监测其脑血流量(CBF)的变化至关重要 以及由于大脑受损部分存在缺血风险而导致的氧合作用。在这项研究中，我们使用了一种杂交 漫反射光学装置表征头位和高氧对脑血流动力学的影响 神经创伤患者，从而评估他们的大脑自动调节。该装置正在研制中。 作为一种便携式、相对便宜的床边监护仪，它采用非侵入性、连续光学 测量CBF变化以及脱氧和氧合血红蛋白浓度的技术。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For patients who have suffered neurotrauma due to traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH), it is of utmost importance to monitor changes in their cerebral blood flow (CBF) and oxygenation due to risk of ischemia in injured parts of the brain. In this study, we used a hybrid diffuse optical device to characterize the hemodynamic effects of head position and hyperoxia on neurotrauma patients, thereby assessing their cerebral autoregulation. The device is being developed as a portable, relatively inexpensive bedside monitor that employs non-invasive, continuous optical techniques to measure changes in CBF as well as deoxy- and oxyhemoglobin concentrations.