BED-SIDE MONITORING OF TRAUMATIC BRAIN INJURY AND STROKE

创伤性脑损伤和中风的床边监测

• 批准号: 8169050
• 负责人: ARJUN G. YODH
• 金额: $ 2.6万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169050
• 关键词: Beds; Brain Part; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Devices; Diffuse; Funding; Grant; Head; Homeostasis; Hybrids; Hyperoxia; Institution; Ischemia; Measures; Monitor; Optics; Oxyhemoglobin; Patients; Positioning Attribute; Research; Research Personnel; Resources; Risk; Side; Source; Stroke; Subarachnoid Hemorrhage; Techniques; Traumatic Brain Injury; United States National Institutes of Health; hemodynamics; injured

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For patients who have suffered neurotrauma due to traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH), it is of utmost importance to monitor changes in their cerebral blood flow (CBF) and oxygenation due to risk of ischemia in injured parts of the brain. In this study, we used a hybrid diffuse optical device to characterize the hemodynamic effects of head position and hyperoxia on neurotrauma patients, thereby assessing their cerebral autoregulation. The device is being developed as a portable, relatively inexpensive bedside monitor that employs non-invasive, continuous optical techniques to measure changes in CBF as well as deoxy- and oxyhemoglobin concentrations.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 对于因创伤性脑损伤（TBI）或蛛网膜下腔出血而遭受神经创伤的患者 脑出血（SAH）时，监测其脑血流量（CBF）的变化至关重要 以及由于脑损伤部位局部缺血的风险而导致的氧合。在这项研究中，我们使用了一种混合动力 漫射光学装置，用于表征头位和高氧对 神经创伤患者，从而评估他们的大脑自动调节。该装置正在开发中 作为便携式、相对便宜的床边监护仪， 测量CBF以及脱氧血红蛋白和氧合血红蛋白浓度变化的技术。