BED-SIDE MONITORING OF TRAUMATIC BRAIN INJURY AND STROKE

创伤性脑损伤和中风的床边监测

• 批准号: 8169050
• 负责人: ARJUN G. YODH
• 金额: $ 2.6万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169050
• 关键词: Beds; Brain Part; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Devices; Diffuse; Funding; Grant; Head; Homeostasis; Hybrids; Hyperoxia; Institution; Ischemia; Measures; Monitor; Optics; Oxyhemoglobin; Patients; Positioning Attribute; Research; Research Personnel; Resources; Risk; Side; Source; Stroke; Subarachnoid Hemorrhage; Techniques; Traumatic Brain Injury; United States National Institutes of Health; hemodynamics; injured

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For patients who have suffered neurotrauma due to traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH), it is of utmost importance to monitor changes in their cerebral blood flow (CBF) and oxygenation due to risk of ischemia in injured parts of the brain. In this study, we used a hybrid diffuse optical device to characterize the hemodynamic effects of head position and hyperoxia on neurotrauma patients, thereby assessing their cerebral autoregulation. The device is being developed as a portable, relatively inexpensive bedside monitor that employs non-invasive, continuous optical techniques to measure changes in CBF as well as deoxy- and oxyhemoglobin concentrations.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 对于因创伤性脑损伤 (TBI) 或蛛网膜下腔而遭受神经损伤的患者 出血（SAH）时，监测脑血流量（CBF）的变化至关重要 以及由于大脑受损部位缺血的风险而导致的氧合。在这项研究中，我们使用了一种混合 漫射光学装置可表征头部位置和高氧对血流动力学的影响 神经外伤患者，从而评估他们的大脑自动调节能力。该设备正在研发中 作为一种便携式、相对便宜的床边监护仪，采用非侵入性、连续光学 测量 CBF 以及脱氧血红蛋白和氧合血红蛋白浓度变化的技术。