BED-SIDE MONITORING OF TRAUMATIC BRAIN INJURY AND STROKE

创伤性脑损伤和中风的床边监测

• 批准号: 8361963
• 负责人: ARJUN G. YODH
• 金额: $ 2.31万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361963
• 关键词: Beds; Brain Part; Cerebrovascular Circulation; Cerebrum; Devices; Diffuse; Funding; Grant; Head; Homeostasis; Hybrids; Hyperoxia; Ischemia; Magnetic Resonance; Measures; Monitor; National Center for Research Resources; Optics; Oxyhemoglobin; Patients; Positioning Attribute; Principal Investigator; Research; Research Infrastructure; Resources; Risk; Side; Source; Stroke; Subarachnoid Hemorrhage; Techniques; Traumatic Brain Injury; United States National Institutes of Health; cost; deoxyhemoglobin; hemodynamics; injured; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. For patients who have suffered neurotrauma due to traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH), it is of utmost importance to monitor changes in their cerebral blood flow (CBF) and oxygenation due to risk of ischemia in injured parts of the brain. In this study, we used a hybrid diffuse optical device to characterize the hemodynamic effects of head position and hyperoxia on neurotrauma patients, thereby assessing their cerebral autoregulation. The device is being developed as a portable, relatively inexpensive bedside monitor that employs non-invasive, continuous optical techniques to measure changes in CBF as well as deoxy- and oxyhemoglobin concentrations.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 适用于因脑外伤(TBI)或蛛网膜下腔而遭受神经创伤的患者 出血(SAH)时，监测其脑血流量(CBF)的变化至关重要 以及由于大脑受损部分存在缺血风险而导致的氧合作用。在这项研究中，我们使用了一种杂交 漫反射光学装置表征头位和高氧对脑血流动力学的影响 神经创伤患者，从而评估他们的大脑自动调节。该装置正在研制中。 作为一种便携式、相对便宜的床边监护仪，它采用非侵入性、连续光学 测量CBF变化以及脱氧和氧合血红蛋白浓度的技术。