BED-SIDE MONITORING OF TRAUMATIC BRAIN INJURY AND STROKE

创伤性脑损伤和中风的床边监测

• 批准号: 8361963
• 负责人: ARJUN G. YODH
• 金额: $ 2.31万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361963
• 关键词: Beds; Brain Part; Cerebrovascular Circulation; Cerebrum; Devices; Diffuse; Funding; Grant; Head; Homeostasis; Hybrids; Hyperoxia; Ischemia; Magnetic Resonance; Measures; Monitor; National Center for Research Resources; Optics; Oxyhemoglobin; Patients; Positioning Attribute; Principal Investigator; Research; Research Infrastructure; Resources; Risk; Side; Source; Stroke; Subarachnoid Hemorrhage; Techniques; Traumatic Brain Injury; United States National Institutes of Health; cost; deoxyhemoglobin; hemodynamics; injured; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. For patients who have suffered neurotrauma due to traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH), it is of utmost importance to monitor changes in their cerebral blood flow (CBF) and oxygenation due to risk of ischemia in injured parts of the brain. In this study, we used a hybrid diffuse optical device to characterize the hemodynamic effects of head position and hyperoxia on neurotrauma patients, thereby assessing their cerebral autoregulation. The device is being developed as a portable, relatively inexpensive bedside monitor that employs non-invasive, continuous optical techniques to measure changes in CBF as well as deoxy- and oxyhemoglobin concentrations.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 对于因脑损伤（TBI）或蛛网膜下腔而导致神经瘤的患者 出血（SAH），监测其脑血流的变化（CBF）至关重要 和由于大脑受伤部分缺血的风险而引起的氧合。在这项研究中，我们使用了混合动力 弥漫性光学装置以表征头部位置和高氧对血液动力学作用 神经瘤患者，从而评估其脑自动调节。该设备正在开发 作为一种便携式，相对便宜的床旁监视器，采用非侵入性，连续的光学 测量CBF以及脱氧血红蛋白浓度的变化的技术。