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CONFORMATIONAL CHANGES IN THE VITAMIN D RECEPTOR UPON LIGAND BINDING

CONFORMATIONAL CHANGES IN THE VITAMIN D RECEPTOR UPON LIGAND BINDING
配体结合时维生素 D 受体的构象变化
批准号:
8168995
负责人:
Hector DeLuca
金额:
$2.61万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-03-01 至 2011-02-28

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The binding of different vitamin D derivatives, which show markedly different physiological responses, to the ligand binding domain of the vitamin D receptor (LBDVDR) yield identical structures obtained by X-ray crystallography Previous NMR studies have shown spectral differences for different ligand complexes for the tryptophan located at the ligand binding site residue. We propose to produce three different types of labeled samples [U-2H,13C,15N], [U-2H,12C,15N] and [U-2H,13C,15N] with selected 1H labeled methyl groups of rLBDVDR to study the structural changes and dynamics properties of the protein-ligand complex with different vitamin D derivatives. Many of these methyl containing residues surround the ligand binding site and should be sensitive reporters of differential binding.
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SYNTHESIS AND BIOLOGICAL ACTIVITY OF A NEW ALL-TRANS-RETINOL METABOLITES
  • 批准号:
    8361148
  • 项目类别:
  • 资助金额:
    $0.09万
  • 财政年份:
    2011
  • 负责人:
    Hector DeLuca
  • 依托单位:
TRAINING IN THE USE OF BRUKER AND VARIAN SPECTROMETERS AND NMR
  • 批准号:
    8361183
  • 项目类别:
  • 资助金额:
    $0.03万
  • 财政年份:
    2011
  • 负责人:
    Hector DeLuca
  • 依托单位:
CONFORMATIONAL CHANGES IN THE VITAMIN D RECEPTOR UPON LIGAND BINDING
  • 批准号:
    8361182
  • 项目类别:
  • 资助金额:
    $3.62万
  • 财政年份:
    2011
  • 负责人:
    Hector DeLuca
  • 依托单位:
TRAINING IN THE USE OF BRUKER AND VARIAN SPECTROMETERS AND NMR
  • 批准号:
    8168996
  • 项目类别:
  • 资助金额:
    $0.03万
  • 财政年份:
    2010
  • 负责人:
    Hector DeLuca
  • 依托单位:
海外基金