Project 1: Genotoxic & Cell Signaling Pathways of As in Mammalian Cells

项目1:基因毒性

基本信息

  • 批准号:
    8065864
  • 负责人:
  • 金额:
    $ 28.52万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-04-21 至 2011-03-31
  • 项目状态:
    已结题

项目摘要

Arsenic is an important environmental carcinogen that affects millions of people worldwide through contaminated water supplies. Although arsenic induces various human cancers including skin, lung, bladder, kidney and liver, the carcinogenic mechanism remains unknown. With the funding support of this grant, the applicant has shown, for the first time, that arsenic is a potent gene and chromosomal mutagen in mammalian cells and induces mostly multilocus deletions. These findings provide the first direct link between chromosomal abnormalities that have frequently been demonstrated in vitro and carcinogenicity in vivo. Furthermore, our recent data have shown that mitochondria are a primary target in mediating arsenicinduced genotoxicity. The overall goal of this application is to elucidate the contribution of mitochondrial DNA mutations and cell signaling pathways in mediating the genotoxicity and apoptosis of arsenic in mammalian cells. To achieve this goal, a series of eight inter-related specific aims are proposed to address the four testable hypotheses. The human-hamster hybrid (A-L) cell assay will be used to ascertain the role of mitochondrial DNA mutations and mitochondrial functions in modulating arsenic (sodium arsenite and methylated arsenic species) induced mutations at the CD59 locus. Since mitochondrial damage is often associated with induction of cell death, human melanocytes and melanoma cells will be used to define the cell signaling pathways involved in mediating arsenic-induced apoptosis. There is a profound necessity to develop effective treatment strategy for this often fatal cancer. Furthermore, there is considerable interaction, both conceptually and in shared materials, between this project and that of Projects 2, 3 and 4. A better understanding of the genotoxic and apoptotic mechanisms of arsenic will provide better interventional approach both in the treatment and prevention of arsenic-induced human diseases.
砷是一种重要的环境致癌物,影响着全球数百万人

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Tom K. Hei其他文献

Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis
  • DOI:
    10.1186/s12967-025-06273-0
  • 发表时间:
    2025-02-27
  • 期刊:
  • 影响因子:
    7.500
  • 作者:
    Hao Huang;Ying Xu;Zi Guo;Miaomiao Zhang;Wanshi Li;Yidan Song;Jing Nie;Wentao Hu;Tom K. Hei;Guangming Zhou
  • 通讯作者:
    Guangming Zhou
RETRACTED ARTICLE: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3
撤回文章:长链非编码 RNA CRYBG3 通过与 Bub3 直接结合干扰纺锤体组装检查点诱导非整倍体
  • DOI:
    10.1038/s41388-020-01601-8
  • 发表时间:
    2021-02-09
  • 期刊:
  • 影响因子:
    7.300
  • 作者:
    Ziyang Guo;Yingchu Dai;Wentao Hu;Yongsheng Zhang;Zhifei Cao;Weiwei Pei;Ningang Liu;Jing Nie;Anqing Wu;Weidong Mao;Lei Chang;Bingyan Li;Hailong Pei;Tom K. Hei;Guangming Zhou
  • 通讯作者:
    Guangming Zhou
Oncogenic transformation by charged particles of defined LET.
定义的 LET 带电粒子的致癌转化。
  • DOI:
  • 发表时间:
    1988
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Tom K. Hei;K. Komatsu;Eric J. Hall;Marco Zaider
  • 通讯作者:
    Marco Zaider
Amplification of arsenic genotoxicity by TiO2 nanoparticles in mammalian cells: new insights from physicochemical interactions and mitochondria
哺乳动物细胞中二氧化钛纳米颗粒放大砷的遗传毒性:来自物理化学相互作用和线粒体的新见解
  • DOI:
    10.1080/17435390.2017.1388861
  • 发表时间:
    2017-09
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Xinan Wang;Yun Liu;Juan Wang;Yaguang Nie;Shaopeng Chen;Tom K. Hei;Zhaoxiang Deng;Lijun Wu;Guoping Zhao;An Xu
  • 通讯作者:
    An Xu
Analysis of mutant frequency curves and survival curves applied to the <em>A<sub>L</sub></em> hybrid cell system
  • DOI:
    10.1016/s0022-5193(88)80194-2
  • 发表时间:
    1988-05-07
  • 期刊:
  • 影响因子:
  • 作者:
    Rodger Parker;Charles Waldren;Tom K. Hei;D.F. Wong;T.L. Puck
  • 通讯作者:
    T.L. Puck

Tom K. Hei的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Tom K. Hei', 18)}}的其他基金

ADMINISTRATIVE CORE
行政核心
  • 批准号:
    8281641
  • 财政年份:
    2011
  • 资助金额:
    $ 28.52万
  • 项目类别:
MECHANISM OF BYSTANDER MUTAGENESIS
旁观者诱变机制
  • 批准号:
    8281639
  • 财政年份:
    2011
  • 资助金额:
    $ 28.52万
  • 项目类别:
MECHANISM OF BYSTANDER MUTAGENESIS
旁观者诱变机制
  • 批准号:
    7992114
  • 财政年份:
    2010
  • 资助金额:
    $ 28.52万
  • 项目类别:
ADMINISTRATIVE CORE
行政核心
  • 批准号:
    7992116
  • 财政年份:
    2010
  • 资助金额:
    $ 28.52万
  • 项目类别:
Cytoplasmic Damage and Genotoxicity
细胞质损伤和遗传毒性
  • 批准号:
    7842077
  • 财政年份:
    2009
  • 资助金额:
    $ 28.52万
  • 项目类别:
Project 1: Genotoxic & Cell Signaling Pathways of As in Mammalian Cells
项目1:基因毒性
  • 批准号:
    7609036
  • 财政年份:
    2008
  • 资助金额:
    $ 28.52万
  • 项目类别:
Cancer Research Core
癌症研究核心
  • 批准号:
    7560893
  • 财政年份:
    2007
  • 资助金额:
    $ 28.52万
  • 项目类别:
Project 1: Genotoxic & Cell Signaling Pathways of As in Mammalian Cells
项目1:基因毒性
  • 批准号:
    7550964
  • 财政年份:
    2007
  • 资助金额:
    $ 28.52万
  • 项目类别:
Project 1: Genotoxic & Cell Signaling Pathways of As in Mammalian Cells
项目1:基因毒性
  • 批准号:
    7089753
  • 财政年份:
    2006
  • 资助金额:
    $ 28.52万
  • 项目类别:
MECHANISMS OF BYSTANDER MUTAGENESIS
旁观者诱变机制
  • 批准号:
    7006856
  • 财政年份:
    2005
  • 资助金额:
    $ 28.52万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 28.52万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了