TRP CHANNEL MODULATION

TRP 通道调制

• 批准号: 8169782
• 负责人: David Julius
• 金额: $ 0.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-12 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169782
• 关键词: Binding; Biochemical; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Cytoplasmic Tail; Esthesia; Funding; Future; Grant; Institution; Mass Spectrum Analysis; Pain; Peptides; Proteins; Research; Research Personnel; Resources; Site; Source; United States National Institutes of Health; crosslink; small molecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to perform biochemical characterization of proteins that modulate the activity of channels important for pain sensation. The targets of study will include channel cytoplasmic domains, small molecule modulators, and peptide modulators. The objective is to purify proteins, determine molecular interaction sites, and perform structural studies.The UCSF mass spectrometry facility will aid us in determining the accurate mass of purified products and confirming the identity of purified products. The aid of the facility will also allow us to interpret results from chemical crosslinking studies in the future.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目的目的是对调节痛觉重要通道活性的蛋白质进行生物化学表征。 研究的目标将包括通道胞质结构域、小分子调节剂和肽调节剂。 目的是纯化蛋白质，确定分子相互作用位点，并进行结构研究。UCSF质谱设备将帮助我们确定纯化产物的准确质量，并确认纯化产物的身份。 该设施的帮助也将使我们能够解释未来化学交联研究的结果。