STRUCTURAL AND FUNCTIONAL STUDIES OF ION CHANNELS AND ION CHANNEL DOMAINS

离子通道和离子通道域的结构和功能研究

• 批准号: 8169778
• 负责人: DANIEL L MINOR
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-12 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169778
• 关键词: Arrhythmia; Brain; Calcium; Cell membrane; Computer Retrieval of Information on Scientific Projects Database; Epilepsy; Funding; Goals; Grant; Heart; Institution; Integral Membrane Protein; Ion Channel; Ion Channel Protein; Ions; Mass Spectrum Analysis; Molecular; Potassium; Protein Fragment; Proteins; Psyche structure; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; United States National Institutes of Health; Work; deafness; genetic regulatory protein; human disease

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Electrical signaling in the brain and heart is driven by the action of ion channel proteins. These proteins from holes in the cell membrane that open and close to allow the passage of ions such as calcium and potassium. We are investigating the structures and functions of a range of ion channels, ion channel regulatory proteins, and transporters. The goals are to uncover the basic biophysical mechanisms by which these transmembrane proteins work, to understand their structures and interactions in atomic detail, and to understand how their functions are compromised in human diseases such as cardiac arrhythmias, epilepsy, deafness, and mental illness.For our research it is essential to know the molecular identity of the proteins and protein fragments that we study. Mass spectrometry provides the most accurate way to make these molecular identifications.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 大脑和心脏中的电信号由离子通道蛋白的作用驱动。 这些蛋白质来自细胞膜上的孔，这些孔打开和关闭以允许钙和钾等离子通过。 我们正在研究一系列离子通道，离子通道调节蛋白和转运蛋白的结构和功能。 我们的目标是揭示这些跨膜蛋白的基本生物物理机制，了解它们的结构和原子细节的相互作用，并了解它们的功能如何在人类疾病，如心律失常，癫痫，耳聋和精神疾病中受到损害。 质谱法提供了最准确的方法来进行这些分子鉴定。